Canonical centriole duplication is much less prone to errors than de novo synthesis of centrioles, but neither depends on self-oligomerization of the centriole protein SAS-6.

An assay to assemble kinetochores de novo was developed and used to identify the role of the CENP-T pathway.

The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.

Styxl2, a sarcomeric muscle-specific pseudophosphatase in vertebrates, functions in sarcomere assembly by promoting protein degradation of non-muscle myosin IIs.

Germline V-gene usage can be inferred from cryoEM reconstructions of antigen-antibody complexes to guide de novo antibody sequencing of complex mixtures by mass spectrometry.

An enhanced bioinformatic pipeline to quantify Plasmodium falciparum core gene and polymorphic var gene expression revealed changes occurring during early culture adaptation of parasites from naturally infected individuals.

Chitons overcome evolutionary constraints through unprecedented genomic dynamism, with extensive chromosomal rearrangements and duplications despite about 300 million years of morphological stasis.

Protein structures with complex topologies can be designed by recombining small independently folded domains.

De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.

TRIM37 prevents the formation of centriolar protein assemblies through an atypical de novo assembly pathway that would otherwise threaten genome integrity.