256 results found
    1. Neuroscience

    A Matlab-based toolbox for characterizing behavior of rodents engaged in string-pulling

    Samsoon Inayat, Surjeet Singh ... Majid H Mohajerani
    Analysis methods for video data of rodents engaged in string-pulling behavior have been developed and used to highlight differences in motion profiles of Swiss Webster and C57Bl/6 mice.
    1. Ecology

    Does bumblebee preference of continuous over interrupted strings in string-pulling tasks indicate means-end comprehension?

    Chao Wen, Yuyi Lu ... Lars Chittka
    Behavioral studies reveal that bumblebees distinguish between continuous and interrupted strings by using a combination of image matching and associative learning.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    IRF4 haploinsufficiency in a family with Whipple’s disease

    Antoine Guérin, Gaspard Kerner ... Jean-Laurent Casanova
    Autosomal dominant IRF4 deficiency is the first genetic etiology of Whipple's disease, a very rare chronic condition following a rather common infection by Tropheryma whipplei.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution of multicellularity by collective integration of spatial information

    Enrico Sandro Colizzi, Renske MA Vroomans, Roeland MH Merks
    Selection for undifferentiated multicellularity emerges in an evolutionary cell-based model because a collective of cells performs chemotaxis better than single cells in a noisy environment.
    1. Biochemistry and Chemical Biology

    Determinants of sugar-induced influx in the mammalian fructose transporter GLUT5

    Sarah E McComas, Tom Reichenbach ... David Drew
    Computational approach shows that the occluded state in GLUT transporters is equivalent to the transition state of soluble enzymes and this has the highest affinity for the substrate sugar.
    1. Cell Biology
    2. Computational and Systems Biology

    Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins

    Alex X Lu, Yolanda T Chong ... Alan M Moses
    100,000s of images from different growth conditions and genetic backgrounds can be integrated into proteome-scale analysis.
    1. Structural Biology and Molecular Biophysics

    Identification of ligand-specific G protein-coupled receptor states and prediction of downstream efficacy via data-driven modeling

    Oliver Fleetwood, Jens Carlsson, Lucie Delemotte
    Ligands with different efficacy profiles shift the free energy landscape of the beta2 adrenergic receptor activation and stabilize diverse active-like states via the switch of microswitches lining an allosteric pathway.
    1. Cell Biology
    2. Developmental Biology

    Uncoupling apical constriction from tissue invagination

    SeYeon Chung, Sangjoon Kim, Deborah J Andrew
    Spatially coordinated apical constriction occurs during Drosophila salivary gland invagination, but the salivary gland can form fully internalized and elongated tubes even when this process is completely blocked.
    1. Cell Biology
    2. Developmental Biology

    JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress

    Andrea Cosolo, Janhvi Jaiswal ... Anne-Kathrin Classen
    Tissue damage induces a reversible cell cycle arrest in G2, which promotes survival and mitogenic signals to facilitate tissue regeneration but drives senescence-like phenotypes under chronic stress conditions.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Massively multiplex single-molecule oligonucleosome footprinting

    Nour J Abdulhay, Colin P McNally ... Vijay Ramani
    A novel single-molecule sequencing method reveals previously unappreciated heterogeneity in nucleosome positioning on individual chromatin fibers across the human genome.

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