Browse our latest Biochemistry and Chemical Biology articles

A critical role for glycosylation on viral entry and methods to use this knowledge to reduce SARS-CoV-2 infectivity has been demonstrated.

At adhesion sites, talin-activated vinculin promotes interactions with the actin network that initiates bundles.

A photoswitchable pore blocker was covalently attached to a cysteine-substituted glutamate delta 2 receptor, to provide optical control of its ion channel function.

Re-characterization of the targets of a commonly used nuclear speckle marker unexpectedly leads to the discovery of the elusive core of the nuclear speckles.

Nanodomain clustering of cAMP effectors represents a novel mechanism of cAMP compartmentation within an oscillatory signaling circuit.

Compartmentalized oscillations of second messengers affect global cellular signaling.

A generalizable approach to understanding the logic of molecular recognition reveals the contributions of individual residues to the specificity of protein-protein interactions.

Cryo-electron microscopic structures of 5-HT₃A receptor in complex with first and second generations of clinically used setron reveal the molecular basis for their binding modes and mechanisms of inhibitory action.

An analysis of author contribution statements in a large number of published papers reveals biases in the career trajectories of scientists.

Structures of CdiB outer membrane transporters reveal the channel-gating mechanism for the secretion of large bacterial toxins.