Browse our latest Biochemistry and Chemical Biology articles

Crystal structures provide structural rationales for the transport stoichiometry of the gastric proton pump, which suffices the energy requirement for the generation of a million-fold proton gradient across the membrane.

A new cell–cell communication system in Streptococcus salivarius, a human gut commensal, discriminates between close signaling molecules to specifically produce bacteriocin-based antimicrobials and disconnects it from foreign DNA acquisition.

Analysis of an essential motif in Mcm4 provides insights into replicative helicase double-hexamer formation and the first step requiring this intermediate during replication initiation.

A novel engineered protein that uncouples electrical signals from downstream biological responses in excitable cells provides a unique investigative tool with potential therapeutic applications.

Trapping of the cell envelope proteome into water-soluble peptidisc library allows high-throughput definition of the membrane protein interactome.

Tight regulation of a central developmental kinase cascade evolved through two key mutations.

Uncovering a mechanism for how inflammatory signaling is opposed by a phosphatase identifies a potential druggable target to treat E. coli sepsis.

Applying ancestral sequence reconstruction techniques to protein kinases reveals the mutations that underlie different modes of activation.

The role of an amino acid-dependent tRNA modification as a nutrient sensor and regulator of metabolic homeostasis has been discovered.

The identification of ACNQ as an extracellular electron shuttle solves a longstanding problem in bacterial physiology and provides new tool for bioenergy development.