Alejandro La Greca, Nicolás Bellora ... Patricia Saragüeta
Binding of progesterone receptor and transcription factor PAX2 to pre-assembled permissive chromatin compartments regulates endometrial cancer gene expression under estrogenic conditions.
Davis Laundon, Nathan Chrismas ... Michael Cunliffe
Three-dimensional cell modelling, lipid analysis, transcriptomics, and live-cell imaging reveal biological insights in to the key stages of the chytrid fungus life cycle.
Katarzyna Szymanska, Karsten Boldt ... Colin A Johnson
Interacting MKS1 and UBE2E1 regulate canonical Wnt signaling through modulation of beta-catenin levels at the base of primary cilium, providing new insights into ciliopathy disease mechanisms.
Ilaria Dutto, Julian Gerhards ... Travis H Stracker
Analysis of adenylosuccinate lyase (ADSL) deficiency in multiple experimental systems reveals cell and organismal phenotypes and impaired neurodevelopment due to the attenuation of ADSL's roles in distinct pathways.
Genetically modified mouse model and comprehensive analysis reveal the molecular mechanisms regulating early T-cell development through intracellular TCRβ expression-mediated β-selection and independent cell survival signaling.
Vibha Kumra Ahnlide, Johannes Kumra Ahnlide ... Pontus Nordenfelt
A method to carefully measure the molecular distance between a site of interest and a reference surface by the repeated acquisition of the two image channels followed by the statistical calculation of the relative difference.
Wouter Huiting, Suzanne L Dekker ... Steven Bergink
Various genotoxic stresses trigger widespread aggregation of abundant, liquid-liquid phase separation-prone proteins, suggesting that genotoxic stress is a potential driver of disease-associated protein aggregation.
Veronika Miskolci, Kelsey E Tweed ... Anna Huttenlocher
Lifetime imaging of endogenous metabolic coenzymes is sensitive to dynamic changes in macrophage activation in a live animal, providing a label-free imaging approach to study immunometabolism in vivo with single-cell, spatial, and temporal resolution.
Nuclei of the true slime mold Physarum polycephalum are continuously shuttled within the cytoplasmic flow across the gigantic syncytium, yet Physarum can establish and maintain gene expression heterogeneity between different structures of the organism.
