Browse our latest Genetics and Genomics articles

Page 83 of 149
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Linking plasmid-based beta-lactamases to their bacterial hosts using single-cell fusion PCR

    Peter J Diebold, Felicia N New ... Ilana L Brito
    One-step Isolation and Lysis (OIL) PCR offers a robust, versatile, accessible, and high-throughput method for linking mobile DNA with bacterial hosts in natural microbial communities.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Introgression shapes fruit color convergence in invasive Galápagos tomato

    Matthew JS Gibson, María de Lourdes Torres ... Leonie C Moyle
    A wild tomato species adopts local fruit color via introgression from an endemic relative, during its invasion onto the Galápagos Islands.
    1. Developmental Biology
    2. Genetics and Genomics

    Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans

    Maria C Ow, Alexandra M Nichitean, Sarah E Hall
    Somatic aging and germline RNAi pathways promote inheritance of ancestral starvation memory through reallocation of fat storage in Caenorhabditis elegans.
    1. Cell Biology
    2. Genetics and Genomics

    Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

    Jiajia Ma, Claire A Scott ... Tom J Carney
    The serine protease Matriptase orchestrates simultaneous epithelial cell motility and inflammation in pathological states through respective activation of the MAPK pathway and generation of hydrogen peroxide.
    1. Genetics and Genomics

    Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease

    Surender Rajasekaran, Caleb P Bupp ... André S Bachmann
    Genetic sequencing has led to the increased diagnoses of rare diseases, strategies such as repurposing drugs and global metabolomics offer promise and bring hope to afflicted families.
    1. Cell Biology
    2. Genetics and Genomics

    An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development

    Courtney M Schroeder, Sarah A Tomlin ... Harmit S Malik
    Non-canonical ‘testis-specific’ actin-related protein (Arp), Arp53D, is critical for early embryonic development in Drosophila, revealing important roles for lineage-specific, divergent, testis-expressed non-canonical Arps outside the male germline in animals.
    1. Genetics and Genomics

    Establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda

    Kevin H-C Wei, Carolus Chan, Doris Bachtrog
    Heterochromatin is established at nucleation sites associated with open chromatin and RNA transcripts and matures into stable domains if they are found near transposable elements targeted by maternally deposited piRNAs.
    1. Genetics and Genomics

    Psychosocial experiences modulate asthma-associated genes through gene-environment interactions

    Justyna A Resztak, Allison K Farrell ... Francesca Luca
    Psychosocial environments modulate genetic risk of asthma and other allergic diseases through altered peripheral blood gene expression.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae

    Rafal Donczew, Steven Hahn
    Yeast bromodomain-containing factors Bdf1/2 offer insights into the biological role of the BET family of transcriptional regulators, which is a promising target in cancer therapy.
    1. Genetics and Genomics
    2. Plant Biology

    Genomic basis for drought resistance in European beech forests threatened by climate change

    Markus Pfenninger, Friederike Reuss ... Barbara Feldmeyer
    European beech harbours substantial genetic variation at genomic loci associated with drought resistance and newly identified loci can help to accelerate and monitor adaptation to climate change.