Scaffolding protein RAPSYN can exert its NEDD8 E3 ligase activity to neddylate and stabilize oncogenic BCR-ABL by competing proteasomal degradation in Ph+ leukemia.
Direct inhibition of pyridoxal phosphatase activity by 7,8-dihydroxyflavone indicates a pharmacological entry point into brain disorders associated with vitamin B6 deficiency.
Thomas RM Germe, Natassja G Bush ... Anthony Maxwell
DNA gyrase, a regulator of bacterial genomes topology, is shown to undergo rearrangements while functioning on DNA in vitro, with important potential consequences for gyrase-targeted antibiotics activity and bacterial evolution.
Single-cell RNA sequencing analysis of diabetic mouse cavernous tissue revealed that LBH is a novel pericyte marker and may interact with Crystallin Alpha B and Vimentin to promote neurovascular regeneration.
A novel bilinear modeling approach reveals genetic code of neuronal connectivity, offering insights for targeted genetic interventions in neural circuits.
LRRK plays an essential, cell-intrinsic role in the protection of dopaminergic neurons during aging, and new genetic findings suggest that LRRK2 mutations may impair its function, leading to dopaminergic neurodegeneration in PD.
The peptidoglycan hydrolase activity of Enterococcus faecium secreted antigen A is crucial for cell wall remodeling during bacterial cell separation and generates muropeptides that stimulate host immunity to enhance immune checkpoint inhibitor anti-cancer therapy.
