Browse our latest research

Page 748 of 1,751
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Misic, a general deep learning-based method for the high-throughput cell segmentation of complex bacterial communities

    Swapnesh Panigrahi, Dorothée Murat ... Tâm Mignot
    A broadly applicable deep-learning based method that recognizes rod-shaped bacteria of virtually any species in complex bacterial communities.
    1. Cancer Biology
    2. Genetics and Genomics

    Multi-syndrome, multi-gene risk modeling for individuals with a family history of cancer with the novel R package PanelPRO

    Gavin Lee, Jane W Liang ... Danielle Braun
    A comprehensive package for pedigree-based risk modeling, with a highly optimized computational back-end, extends existing models beyond syndrome-specific approaches and incorporates data from panel studies by allowing for an arbitrary number of gene and syndrome associations.
    1. Neuroscience

    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

    Gustavo Della-Flora Nunes, Emma R Wilson ... M Laura Feltri
    mTORC1 and c-Jun are implicated in a possible mechanism causing myelin loss downstream of mitochondrial dysfunction in Schwann cells.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Enhanced Cas12a multi-gene regulation using a CRISPR array separator

    Jens P Magnusson, Antonio Ray Rios ... Lei S Qi
    Cas12a CRISPR arrays are sensitive to the GC content of their spacers, but AT-rich separator sequences successfully remove this disruptive effect and enable enhanced multiplexed gene targeting and activation.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

    Charanya Kumar, Sahil Batra ... Dirk Remus
    Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork progression.
    1. Cell Biology

    Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

    Yoanna Ariosa-Morejon, Alberto Santos ... Tonia L Vincent
    Protein dynamics signatures in ageing collagen-rich tissues that are central to frequent age-related diseases such as osteoporosis and osteoarthritis.
    1. Developmental Biology
    2. Evolutionary Biology

    Deep evolutionary origin of gamete-directed zygote activation by KNOX/BELL transcription factors in green plants

    Tetsuya Hisanaga, Shota Fujimoto ... Keiji Nakajima
    Gamete-derived three-amino-acid-loop-extension homeodomain proteins activate zygote development in a strikingly similar manner between basal land plants and green algae, indicating an ancestral role of these transcription factors in green plants.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Mechanically transduced immunosorbent assay to measure protein-protein interactions

    Christopher J Petell, Kathyrn Randene ... Joshua P Steimel
    METRIS is a method that reports a mechanical readout of protein-protein interactions and due to its unique properties, it will allow many protein-protein interactions to be quantitatively measured easily that are currently laborious to measure with conventional methods.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants

    Elizabeth Jaworski, Rose M Langsjoen ... Andrew L Routh
    Tiled-ClickSeq provides a simple and novel next-generation sequencing approach for complete genome sequencing of viruses including SARS-CoV-2, whilst capturing RNA recombination events and minority variants.
    1. Microbiology and Infectious Disease

    PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans

    Ankur V Patel, Robert D Turner ... Stéphane Mesnage
    PGFinder is an open-source software dedicated to the analysis of peptidoglycan mass spectrometry data that paves the way for peptidoglycomics.