Browse our latest research

Single-cell transcriptomics of intraocular infiltrate in human HLA-B27-associated active anterior uveitis shows a unique composition and phenotype of leukocytes preferentially affecting dendritic cells.

Acyloxyacyl hydrolase, the host lipase that detoxifies bacterial lipopolysaccharides, also deacylates oxidized phospholipids, preventing inflammasome activation in macrophages in vitro and ameliorating acute lung injury in vivo.

Using single nucleus RNA sequencing, a complete catalogue of cell types was determined for the mouse iris, and this information was used as a starting point to define the effects of pupil dilation on gene expression and on nuclear morphology.

Developing Monosiga brevicollis as a model to study choanoflagellate immune responses reveals that the innate immune protein STING mediates responses to cyclic dinucleotides in choanoflagellates, providing insight into the evolution of STING signaling on the animal stem lineage.

A G1 cyclin shows key properties expected of a protein that could link cell cycle progression to cell growth.

A series of experiments at the molecular level reveal the underlying mechanism of how a gene activates liver glucose production to regulate the blood glucose metabolism in mice.

Cold detecting thermoreceptor TRPM8's signalling is diminished with ageing which leads to an impaired response to cold observed in ageing.

Structures of human SMG1-9 and SMG1-8-9 reveal how the SMG1 kinase active site is targeted by a specific inhibitor and provide insights into the regulation of the SMG1-8-9 kinase complex in nonsense-mediated mRNA decay.

Genetic analysis identifies the origins of midface defects in mouse models of ciliopathies, revealing a role for ciliary Hedgehog signaling in cell survival.

Organ-selective drug action of traditional Chinese medicine that generates systemic immune mediators is proposed and reviewed as a novel mechanistic angle to develop new immunomodulatory drugs.