Browse our latest research

Page 824 of 1,742
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

    Francesco Beghini, Lauren J McIver ... Nicola Segata
    The bioBakery 3 platform enables improved, integrated, and strain-level analysis of microbial communities from large-scale meta-omic data.
    1. Ecology
    2. Microbiology and Infectious Disease

    Multiple lineages of Streptomyces produce antimicrobials within passalid beetle galleries across eastern North America

    Rita de Cassia Pessotti, Bridget L Hansen ... Matthew F Traxler
    The widespread occurrence of metabolically active streptomycetes in Odontotaenius disjunctus beetle frass may insulate their galleries against pathogenic fungal invasion through the production of diverse antimicrobial specialized metabolites.
    1. Genetics and Genomics

    Whole-genome sequencing analysis of semi-supercentenarians

    Paolo Garagnani, Julien Marquis ... Claudio Franceschi
    Genetic variants located in DNA repair genes and a reduced burden of somatic mutations protect the oldest living persons from age-related diseases, allowing an healthy aging phenotype.
    1. Structural Biology and Molecular Biophysics

    The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

    Achinta Sannigrahi, Sourav Chowdhury ... Krishnananda Chattopadhyay
    How do the metal cofactors present in the protein SOD1 collaborate with the interacting membrane to define the role of this protein in the disease ALS?
    1. Cancer Biology
    2. Cell Biology

    Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

    Linda Julian, Gregory Naylor ... Michael F Olson
    In the absence of ROCK1 activation by caspases, apoptotic cells don’t undergo typical morphological changes, leading to sterile inflammation in the liver that increases tissue damage and suppresses tumor formation.
    1. Neuroscience

    An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

    Bo-yong Park, Richard AI Bethlehem ... Boris C Bernhardt
    Manifold learning of longitudinal brain network data provides novel insights into adolescent structural connectome maturation, and how multiple scales of cortical and subcortical organization interact in typical neurodevelopment.
    1. Cell Biology
    2. Medicine

    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

    Takeshi Ninchoji, Dominic T Love ... Lena Claesson-Welsh
    Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction stability and barrier integrity can be restored by blocking formation of nitric oxide.
    1. Medicine
    2. Neuroscience

    Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials

    Maria M Cobo, Caroline Hartley ... Rebeccah Slater
    Measuring individual differences in noxious-evoked baseline sensitivity in neonates can substantially reduce sample sizes required in neonatal analgesic trials.
    1. Computational and Systems Biology

    Associations of topic-specific peer review outcomes and institute and center award rates with funding disparities at the National Institutes of Health

    Michael S Lauer, Jamie Doyle ... Deepshikha Roychowdhury
    An analysis of peer review and funding outcomes of NIH research applications shows that funding disparities of topics preferred by African American Black investigators are not due to peer review preferences or biases.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High social status males experience accelerated epigenetic aging in wild baboons

    Jordan A Anderson, Rachel A Johnston ... Jenny Tung
    Among the factors that predict fitness in wild baboons, dominance rank in males, but not in females, is the best predictor of epigenetic aging.