Browse our Research Articles

Page 574 of 1,486
    1. Microbiology and Infectious Disease

    Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection

    Zaigham Abbas Rizvi, Rajdeep Dalal ... Amit Awasthi
    SARS-CoV-2 infection in hamsters causes cardiovascular pathologies.
    1. Cell Biology
    2. Immunology and Inflammation

    RNA N6-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice

    Bochuan Li, Ting Zhang ... Degang Liang
    METTL3 and m6A modifications could alleviate endothelial activation and atherogenesis through accelerated degradation of oscillatory flow-induced EGFR mRNA expression.
    1. Computational and Systems Biology
    2. Neuroscience

    Sex differences in learning from exploration

    Cathy S Chen, Evan Knep ... Nicola M Grissom
    A new computational analysis of decision making in mice shows sex biases in value-updating while exploring unknown options, with male mice tending to explore longer than females due to updating values more slowly.
    1. Microbiology and Infectious Disease

    Multi-omics investigation of Clostridioides difficile-colonized patients reveals pathogen and commensal correlates of C. difficile pathogenesis

    Skye RS Fishbein, John I Robinson ... Gautam Dantas
    Integration of clinical patient data, pathogen information and a multi-omic analysis of the gut microbiome reveals key determinants of disease in C. difficile-colonized patients.
    1. Epidemiology and Global Health

    Risk factors relate to the variability of health outcomes as well as the mean: A GAMLSS tutorial

    David Bann, Liam Wright, Tim J Cole
    We provide a tutorial to use GAMLSS, applied using cohort data to study how risk factors may influence both the mean and variability of body mass index and mental health.
    1. Chromosomes and Gene Expression

    Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae

    Fernando Rodrigo Rosas Bringas, Sonia Stinus ... Michael Chang
    Telomere-specific depletion of Rap1, the main sequence-specific telomere-binding protein in Saccharomyces cerevisiae, can be tolerated due to the presence of secondary telomere capping mechanisms, which may help explain the rapid evolution of budding yeast telomeres.
    1. Epidemiology and Global Health
    2. Medicine

    Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort

    ISARIC Clinical Characterisation Group, Matthew D Hall ... Piero L Olliaro
    Patient outcomes, and the time spent by patients during hospital admission, showed considerable variation over the first year of the COVID-19 pandemic.
    1. Evolutionary Biology

    Activation by cleavage of the epithelial Na+ channel α and γ subunits independently coevolved with the vertebrate terrestrial migration

    Xue-Ping Wang, Deidra M Balchak ... Ossama B Kashlan
    Proteolytic activation of a sodium-permeable channel that aids in gas exchange and fluid homeostasis likely evolved at the water to land transition in vertebrates.
    1. Plant Biology

    Plant Trans-Golgi Network/Early Endosome pH regulation requires Cation Chloride Cotransporter (CCC1)

    Daniel W McKay, Heather E McFarlane ... Stefanie Wege
    Cation chloride cotransporter CCC1 has a central function in plant cells and is the missing ion efflux component of the transport circuit necessary to regulate pH in the lumen of the trans-Golgi-network/early endosome, the major cargo hub in plant cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation

    Lindsay B Case, Milagros De Pasquale ... Michael K Rosen
    Biochemical and cell biological data suggest a model of nascent integrin adhesion complex formation based on synergistic phase separation of pathways surrounding the focal adhesion kinase (FAK) and the adaptor protein p130Cas.