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Single molecule reconstitution of PI3Kβ synergistic activation reveals mechanism for rapid PI(3,4,5)P₃ production during immune cell signaling.

Empirical experiments and computational modeling reveal a stochastic world model on gravity for stability inference that represents gravity’s vertical direction as a Gaussian distribution.

Insights from integrating evolutionary predictions and protein dynamics unveil how specific mutations in the SARS-CoV-2 spike protein epistatically interact in order to influence spike protein interaction with human cells, potentially altering the virus's infectivity and immune evasion capabilities.

Internal neural variability can induce drift of memory ensembles through synaptic plasticity, allowing for encoding of temporal information.

Collaborative hunting, characterized by the division of roles among predators, has emerged within a group of artificial agents through deep reinforcement learning.

Revealing YBR238C's involvement in the TORC1–mitochondria feedback loop deepens our understanding of aging biology, emphasizing the TOMITO concept as a crucial mechanism in cellular aging regulation.

The NMDA receptor might preferentially mediate immediate experience/impact of events with negative over positive valence.

A mouse model of maturity-onset diabetes of the young illuminates that overactive TALK-1 channels limit β-cell calcium influx through membrane potential hyperpolarization, which blunts insulin secretion and causes glucose intolerance.

Psychophysical measurement and computational modeling show that sensory information cannot contribute directly to a cognitive judgment, but must first be integrated into resource-limited working memory.

CCK released from the neural projections from the rhinal cortex to the motor cortex modulates neural plasticity and facilitates motor skill learning.