Magazine

Highlighting the latest research and giving a voice to scientists
Illustration by Davide Bonazzi

Highlights

    1. Cell Biology
    2. Chromosomes and Gene Expression

    A crossroads in the aging process

    Kiyan Shabestary, Daniel E Gottschling
    1. Neuroscience

    The power of chemogenetics

    Maria Puchik, Igor Kagan
    1. Neuroscience

    Hunger and neuronal migration

    Fang-Shin Nian, Laurent Nguyen
    1. Genetics and Genomics
    2. Neuroscience

    How stress can extend lifespan

    Loren Cocciolone, Valeria Uvarova, Patricija van Oosten-Hawle

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Latest articles

    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacteriology: How Shigella tackles host defences

    Yizhou Huang, Teresa LM Thurston
    The pathogenic bacteria Shigella avoids detection inside hosts cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.
    Version of Record
    Insight
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromosomes: Exploring a crossroads in the aging process

    Kiyan Shabestary, Daniel E Gottschling
    Experiments on yeast show that the nuclear pore complex has a central role in the loss of chromosomes associated with aging.
    Version of Record
    Insight
    1. Neuroscience

    Neuronal Migration: How hunger guides new brain cells to their destination

    Fang-Shin Nian, Laurent Nguyen
    Blood flow and a hormone called ghrelin help new neurons travel to where they are meant to be in the brain of adult mice.
    Version of Record
    Insight
    1. Neuroscience

    Primate Research: Probing the staying power of chemogenetics

    Maria Puchik, Igor Kagan
    A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of nonhuman primates.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Neuroscience

    Aging: Unlocking the longevity code with stress

    Loren Cocciolone, Valeria Uvarova, Patricija van Oosten-Hawle
    Manipulating the neuronal pathway responsible for the hypoxic stress response in the worm C. elegans leads to an increase in lifespan.
    Version of Record
    Insight
    1. Developmental Biology

    Blastomeres: Tracing cell fates in embryos

    Ying Zhang, Qi Chen
    Differences in the activity of an enzyme called CARM1 influence the timing of blastomere polarization and whether they become part of the embryo or the placenta.
    Version of Record
    Insight
    1. Cancer Biology

    Transcription Factor-Dependent Cancers: Targeting chromatin remodeling complexes to treat uveal melanoma

    Jonas A Nilsson
    A novel compound that inhibits the BAF chromatin remodeling complex causes regression in an animal model of the incurable cancer uveal melanoma.
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    Insight
    1. Structural Biology and Molecular Biophysics

    Enzyme Dynamics: Capturing enzymes in motion

    Álvaro de la Gándara, Agnieszka A Kendrick
    A combination of cryogenic electron microscopy and molecular simulations has been used to study the structure and dynamics of an enzyme called ACE.
    Version of Record
    Insight
  1. Living Science: My grandmother’s rug

    Eve Marder
    The objects that migrants carry with them are tethers to the lives they have left behind.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Wnt Signaling: Exploring the origins of a signaling pathway

    Balaji Santhanam
    The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.
    Version of Record
    Insight