Analysis of mouse zygotic genome activation (ZGA) reveals that a mis-annotated multicopy homeobox gene Obox4 functions redundantly with Dux to promote ZGA.

The developmental transcription factor DUX4 interacts with STAT1 and broadly suppresses expression of IFNγ-stimulated genes.

Electrophysiology and information theory show that diverse classes of mechanoreceptors in the face inform the mouse brain about whisking.

Reactive oxygen species can activate the ATR/Chk1 pathway in the absence of detectable DNA damage and without a requirement for DNA damage response proteins.

Bacterial location quantifications highlights how Drosophila melanogaster larvae discriminate bacteria to isolate and later eliminate pathogens in the anterior midgut through coordinated mechanisms involving reactive oxygen species (ROS) and antimicrobial peptides (AMPs).

ATR protects stem cell genomes by activating a transcriptional response mediated by totipotency genes, conferring trophoblast differentiation potential, the derepression of which in somatic cells might favour cancer features emergence.

The serine protease Matriptase orchestrates simultaneous epithelial cell motility and inflammation in pathological states through respective activation of the MAPK pathway and generation of hydrogen peroxide.

Detailed molecular characterization of a constitutively active bacterial NADPH oxidase (NOX) provides clues to the activation mechanism required to trigger electron transfer and reactive oxygen species (ROS) production in tightly regulated eukaryotic NOX.

The inhibition of EPAC1, a cAMP-binding protein, appears as a potential therapeutic strategy to limit doxorubicin-induced cardiotoxicity without interfering with its antitumoral activity.

Doxycycline used at a slightly higher concentration kills Plasmodium falciparum malaria parasites with faster, first-cycle activity through a novel organelle-specific mechanism.