4,282 results found
    1. Immunology and Inflammation
    2. Medicine

    Bacterial–fungal interactions in the neonatal gut influence asthma outcomes later in life

    Rozlyn CT Boutin, Charisse Petersen ... B Brett Finlay
    Overgrowth of the yeast Pichia kudriavzevii within the neonatal gut microbiota increases allergic airway disease severity later in life and may be inhibited by short-chain fatty acids.
    1. Neuroscience

    Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images

    Rohan Gala, Daniel Lebrecht ... Armen Stepanyants
    BoutonAnalyzer software makes it possible to detect axonal boutons and measure their structural plasticity in long-term in vivo imaging experiments.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A putative origin of the insect chemosensory receptor superfamily in the last common eukaryotic ancestor

    Richard Benton, Christophe Dessimoz, David Moi
    Comparative genomics and three-dimensional protein modelling identify homologs of insect chemosensory receptors in unicellular eukaryotes and plants.
    1. Immunology and Inflammation

    B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

    Lieselotte SM Kreuk, Meghan A Koch ... Gregory M Barton
    Microbial-sensing TLRs drive responses to the microbiota, while nucleic-acid sensing TLRs control responses to endogenous ligands, revealing novel regulation of B-1a responses through integrated BCR/TLR mediated activation.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

    Florian Heigwer, Christian Scheeder ... Michael Boutros
    Genetic interaction analysis by combinatorial genetic perturbation and high-throughput imaging maps time- and context-dependent crosstalk between signaling pathways.
    1. Developmental Biology
    2. Plant Biology

    The Arabidopsis transcription factor ABIG1 relays ABA signaled growth inhibition and drought induced senescence

    Tie Liu, Adam D Longhurst ... M Kathryn Barton
    Arabidopsis plants slow growth and jettison leaves in response to drought via a mechanism that involves the transcription factor ABIG1.
    1. Developmental Biology
    2. Neuroscience

    Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants

    J Roman Arguello, Liliane Abuin ... Richard Benton
    Targeted expression of molecular probes for gene expression and chromatin accessibility in subpopulations of neurons in the Drosophila olfactory system identifies genes required for their development and function.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains

    Rachael E Barton, Lucia F Massari ... Adèle L Marston
    Meiotic recombination and chromosome segregation require the establishment of chromatin boundaries by the acetyltransferase Eco1, which anchors both chromatin loops and cohesion.
    1. Neuroscience

    Vocal and locomotor coordination develops in association with the autonomic nervous system

    Morgan L Gustison, Jeremy I Borjon ... Asif A Ghazanfar
    Marmoset monkeys develop their vocal behavior prior to their postural and locomotor skills, but the coordination of these two motor systems emerges gradually via changes in arousal level.
    1. Evolutionary Biology

    Fog signaling has diverse roles in epithelial morphogenesis in insects

    Matthew Alan Benton, Nadine Frey ... Siegfried Roth
    Fog signaling with a narrow morphogenetic role in Drosophila has a deeply conserved function in epithelial morphogenesis across insects.

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