A high-throughput small molecule screen defined compounds that inactivate primary human hepatic stellate cells (HSCs) and led to the identification of nanchangmycin, which regulates intracellular Ca²⁺ levels and the activity of multiple kinases to control HSC fibrotic activity.

Structure-based virtual screening reveals multiple novel TRPV5 inhibitors that bind and exert their effect from previously unidentified binding sites as characterized by cryo-electron microscopy and electrophysiology.

A high-throughput phenotypic human sperm screening platform was developed which allows for major drug discovery programmes for male contraception.

Large scale virtual screening using recently solved structures of Melatonin receptors yield discovery of 10 new high-affinity selective agonists, also revealing novel functional features, including biased signaling at Melatonin receptors.

Small molecule inhibitors identified in a biophysical high-throughout screening assay confirm the importance of the interaction between single-stranded DNA and the protein RAD52 for the survival of BRCA2-depleted cells.

This microscale cultivation strategy will help in the discovery of novel bacterial species and their prioritization for antibiotic screening campaigns.

The mode of binding and cellular effect of the first FOXO3-DNA-binding-domain targeting small compound discovered by a combined pharmacophore-based/biochemical screening approach is reported.

A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.

A small molecule compound Dwn1, identified through high-throughput screening using Npas2 as the molecular target, enhances wound healing in a murine incisional wound model.

The oral carbapenem 'Tebipenem' has high level antibacterial activity against highly drug-resistant Shigella, and its mode of action and pharmacokinetics make it suitable for the treatment of severe diarrhoea caused by highly drug-resistant bacteria.