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Laterally associating specific ESCRT-III subunits can replace one another with simple modifications, providing insights into the design principles of ESCRT-III heteropolymerization.

The giant KASH protein ANC-1 maintains the integrity of the cytoplasm to anchor nuclei, ER, and other organelles within the cell.

Experiments in C. elegans reveal new insights into how the ANC-1 protein helps to anchor the nucleus and other organelles in place.

Amphiphysin I is identified as a new substrate of AEP, and the resultant fragment induces synaptic dysfunction and promotes tau hyperphosphorylation via activating CDK5 kinase.

Genetic and cellular studies in rodents found branched-chain amino acids are critical nutrients that are transported and oxidized in the mitochondria through their carrier MBC for optimal febrile responses.

Prokaryotes use polycistronic messages for coordinated translation, whereas eukaryotic cells may achieve tunable protein synthesis by packaging monocistronic mRNAs into functional multiplexes via co-transcriptional interallelic coupling and non-canonical histone-H4 functions.

Mechanical competition is controlled by biophysical parameters that regulate cellular homeostatic density, while biochemical competition is regulated by parameters that influence the organisation of cells in a tissue.

By linking export and licensing of a piRNA precursor transcript, channel nuclear pore complex subunits Nup54 and Nup58 are specifically required to silence transposons in the Drosophila ovary.

Loss of the transcription factor Rreb1 results perturbs epithelial architecture during mouse development resulting in invasive cell behaviors, severe cardiovascular defects, and embryonic lethality.

Fundc1-mediated mitophagy protects renal EPO-producing cells from myofibroblastic conversion under stresses.