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Mammalian cellular iron homeostasis and the maturation of the cytosolic iron sulfur cluster proteins are dependent on the mitochondrial protein import machinery.

Forces stemming from cell-matrix adhesions, but not cell-cell adhesions, are directly transmitted to the nuclear lamina to regulate epidermal cell fate.

Neuronal junctophilins 3 and 4 similarly recruit and functionally modify P/Q and N-type calcium channels, but differentially recruit the three ryanodine receptor isoforms to endoplasmic reticulum-plasma membrane junctions.

A whole-genome genetic screen links new aspects of oocyte maturation to proteostasis renewal in the immortal Caenorhabditis elegans germ-cell lineage and reveals similarities to somatic cell maintenance during aging.

Extended somatic hypermutation and clonal evolution associated with antibody neutralization breath in HIV controllers with low plasma viral loads provide promise for HIV vaccine development.

Heterotrimeric G-proteins can be switched on not only by G-protein-coupled receptors but also by cytoplasmic proteins, resulting in different signaling mechanisms in cells depending on the specific type of activator.

Rab25a and Rab25b mutant embryos exhibit epithelial spreading delays during morphogenesis and are characterized by cytokinesis defects leading to cell fusions, heterogeneous epithelial cell sizes, and reduced cortical actomyosin contractility.

Mechanical loading and the bone anabolic action of parathyroid hormone result in rapid, lysosomal degradation of sclerostin protein, revealing physiologically important post-translational control of this critical regulator of bone formation.

'Cellular Electron Microscopy 500,000 images' (CEM500K) is a highly heterogeneous, information-rich, non-redundant, unlabeled EM dataset curated to pre-train DL algorithms for better model generalization on EM segmentation tasks.

An extracellular modulator of IGF1 signaling, Pappaa, regulates endoplasmic reticulum–mitochondria connections, which are critical for metabolic homeostasis and hair cell survival.