Browse our latest Computational and Systems Biology articles

Page 117 of 130
    1. Computational and Systems Biology
    2. Neuroscience

    Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons

    Philipe RF Mendonça, Mariana Vargas-Caballero ... Hugh PC Robinson
    A-type potassium conductances influence the distinctive firing behaviour of irregular-spiking interneurons.
    1. Computational and Systems Biology
    2. Neuroscience

    Resolving coiled shapes reveals new reorientation behaviors in C. elegans

    Onno D Broekmans, Jarlath B Rodgers ... Greg J Stephens
    A conceptually simple algorithm can analyze previously uncharacterized 2D coiled postures of the nematode C. elegans and has uncovered new reorientation behaviors in large amplitude turns.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Avoidance of stochastic RNA interactions can be harnessed to control protein expression levels in bacteria and archaea

    Sinan Uğur Umu, Anthony M Poole ... Paul P Gardner
    Stochastic mRNA and non-coding RNA hybridisation has a major impact on protein expression.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A systematic view on influenza induced host shutoff

    Adi Bercovich-Kinori, Julie Tai ... Noam Stern-Ginossar
    During host shut-off caused by the Influenza A virus, cellular genes that play important housekeeping roles for the virus are still efficiently translated.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    The selectivity of the Na+/K+-pump is controlled by binding site protonation and self-correcting occlusion

    Huan Rui, Pablo Artigas, Benoît Roux
    Computations based on detailed atomic models explain how the ATP-driven sodium-potassium pump avoids transporting the wrong type of ions in order to maintain the physiological concentration of sodium and potassium ions across the cell membrane.
    1. Cell Biology
    2. Computational and Systems Biology

    Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination

    Benjamin Groves, Arjun Khakhar ... Georg Seelig
    Two sets of modular components are sufficient to rewire MAPKs to regulate proteins through ubiquitination – a complementary pair of protein interaction domains and a phosphodegron.
    1. Computational and Systems Biology
    2. Neuroscience

    Na+/K+ pump interacts with the h-current to control bursting activity in central pattern generator neurons of leeches

    Daniel Kueh, William H Barnett ... Ronald L Calabrese
    The dynamic current generated Na+/K+ pump interacts with the h-current to control the bursting activity of oscillator heart interneurons.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4

    John M Nicoludis, Bennett E Vogt ... Rachelle Gaudet
    Clustered and non-clustered protocadherins form antiparallel homodimers in which distinct regions of the extended interface demonstrate a division of labor between driving affinity and determining specificity.