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Depletion of vsx genes in zebrafish confirms a conserved role in bipolar cells specification across vertebrates, but do not interfere with the formation of the neural retina domain, which reveal an unexpected robustness of the genetic network sustaining the retina.

Local sequence context, length, and GC nucleotide content in both directions of the trimming site, together, are highly predictive of V(D)J trimming probabilities for both TR and IG adaptive immune receptor loci.

retro-Tango, developed and validated in multiple circuits in Drosophila melanogaster, is established as a genetically encoded, transsynaptic labeling system in the retrograde direction.

Oscillations that co-occur in hippocampal CA1 during exploration in the rodent are shown to segregate according to exploratory and sleep states in the primate.

Sodium selenate is the first treatment with persistent disease-modifying effects reducing seizures and improving cognitive deficits, in chronically epileptic and drug-resistant TLE animals.

Missense mutations in the nuclear-encoded adenine nucleotide translocase 1 (Ant1) cause the protein to clog the mitochondrial protein import pathway, to severely inhibit cell growth in yeast, and to cause neurodegeneration and myopathy in mice that phenocopy ANT1-induced human disease.

Alveolar type 2 stem cells are actively maintained by Hippo signaling and Taz promotes alveolar epithelial regeneration and the resolution of bleomycin induced pulmonary fibrosis upon inactivation of the Hippo pathway in Alveolar type 2 stem cells.

The pulsatile activities of kisspeptin neurons, the central pacemaker activities of reproductive functions, show unexpected robustness in terms of frequency, but a tendency for the intensity to decline, during the transition to reproductive senescence in mice.

LeishBASEedit enables gene editing in Leishmania without requiring DNA double-strand breaks, homologous recombination, or donor DNA, thereby facilitating loss-of-function screens via delivery of plasmid libraries and regardless of limitations due to gene copy number variations and/or lack of RNAi components.

The genomic features associated with a gene fate to loss have been retained for approximately 500 million years during evolution, and the genes with these features exhibit restricted expression profiles, leading to the genes being less important.