Alireza Ghasemizadeh, Emilie Christin ... Vincent Gache
Maintenance of peripheral myonuclei patterning in skeletal myofibers is dependent on the regulation of microtubules dynamic and nuclei motion and is essential for proper neuromuscular junction integrity and mitochondria homeostasis.
Filopodia driven by class X myosin promote the fusion of mammalian myoblasts in the development of skeletal muscle and are important for the regeneration of skeletal muscle following muscle injury.
Pamela Himadewi, Xue Qing David Wang ... Xiaotian Zhang
The 3'HS1 CTCF binding site directly modulates chromosomal loops to regulate γ-globin expression through the accession of the hereditary persistence of fetal hemoglobin enhancer.
Subthalamic nucleus spiking activity, beta oscillation power, and locking of spikes to the beta oscillation are decreased prior to changes in ongoing movements.
William N Zagotta, Brandon S Sim ... Sharona E Gordon
Time-resolved transition metal ion fluorescence resonance energy transfer using a fluorescent, noncanonical amino acid donor and metal ion acceptor measures distances and distance distributions in proteins, allowing the equilibrium distributions among conformational states to be accurately determined.
A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.
Emily R Ebel, Frans A Kuypers ... Elizabeth S Egan
Human red blood cells from healthy donors display marked biophysical and genetic variation that impacts the growth of Plasmodium falciparum malaria parasites, outside of known disease alleles.
Katherine B LeClair, Kenny L Chan ... Scott J Russo
Socially dominant mice, unlike subordinates, are protected from displaying a common stress-associated behavioral deficit, social avoidance, following exposure to multiple kinds of chronic stress.
A trait-based model of dryland vegetation uncovers the roles of spatial self-organization in maintaining biodiversity in a changing climate and offers novel ways of managing ecosystems at risk.
Sonia Accossato, Felix Kessler, Venkatasalam Shanmugabalaji
SUMOylation contributes to the fine-tuning of the proteostatic equilibrium of essential chloroplast protein import receptor TOC159 at early plant development.
