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Page 856 of 1,838
    1. Structural Biology and Molecular Biophysics

    Analysis of the mechanosensor channel functionality of TACAN

    Yiming Niu, Xiao Tao ... Roderick MacKinnon
    Electrophysiological and structural data do not support a mechanosensitive channel function for TACAN.
    1. Cell Biology
    2. Developmental Biology

    GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility

    Sequoyah Reynoso, Vanessa Castillo ... Pradipta Ghosh
    Spermatozoa require GIV for specialized compartmentalized signaling to support efficient capacitation while inhibiting premature acrosome reaction.
    1. Computational and Systems Biology

    Variation in the modality of a yeast signaling pathway is mediated by a single regulator

    Julius Palme, Jue Wang, Michael Springer
    Yeast cells can tune the modality of a nutrient response on physiological and evolutionary timescales by adapting the expression and sequence of a sensor protein.
    1. Neuroscience

    Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

    Cheng Qian, Zhaofa Wu ... Yulong Li
    Identification of novel vesicular transporters will shed light on to expanding the chemical diversity of neurotransmitters or neuromodulators.
    1. Cancer Biology
    2. Medicine

    Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

    S Jordan Kerns, Chaitra Belgur ... Lauriane Cabon
    Novel human models of the lung and intestine are described and validated as preclinical in vitro tools for predictive profiling of T-cell-bispecific antibodies with expected on-target off-tumor risk.
    1. Neuroscience

    Cortical excitability signatures for the degree of sleepiness in human

    Chin-Hsuan Chia, Xin-Wei Tang ... Rui-Ping Hu
    Patterns of cortical excitability changes reflect the degree of sleepiness in humans.
    1. Developmental Biology

    Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration

    Ines Lahmann, Joscha Griger ... Carmen Birchmeier
    Met and Cxcr4 signaling protects muscle stem cells from the noxious environment during acute inflammation.
    1. Epidemiology and Global Health
    2. Medicine

    Role of direct and indirect social and spatial ties in the diffusion of HIV and HCV among people who inject drugs: a cross-sectional community-based network analysis in New Delhi, India

    Steven J Clipman, Shruti H Mehta ... Sunil S Solomon
    Beyond well-recognized individual-level risk factors, HIV and hepatitis C transmission among people who inject drugs are further impacted by social and spatial network composition, and spaces in particular may represent efficient means for disseminating interventions that diffuse through the network.
    1. Evolutionary Biology
    2. Neuroscience

    Neural mechanisms of modulations of empathy and altruism by beliefs of others’ pain

    Taoyu Wu, Shihui Han
    Beliefs of others’ pain provide a cognitive basis of human empathy and altruism by modulating empathic brain activity.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity

    Margaret A Myers, Amanda P Smith ... Amber M Smith
    Important nonlinear links between infection, inflammation, and disease severity were revealed using experimentally validated mathematical models.