Browse our Insights

Page 27 of 114
    1. Cell Biology

    Alternative Splicing: A new role for Hif-1α

    Mingyu Shin, Jiwon Shim
    A gene normally involved in responding to hypoxia helps to protect insect muscles during migratory flight in a non-oxygen dependent manner.
    Version of Record
    Insight
    1. Cancer Biology

    Androgen Receptor: How splicing confers treatment resistance in prostate cancer

    Prathyusha Konda, Srinivas R Viswanathan
    A splice variant of the androgen receptor that drives prostate cancer resistance translocates into the nucleus using a different mechanism from the full-length receptor and exhibits distinct molecular properties once inside.
    Version of Record
    Insight
    1. Medicine

    Gaucher Disease: Microglia orchestrate neuroinflammation

    Ricardo A Feldman
    Experiments in genetically altered mice reveal that microglia play an important role in the neurological damage associated with neuro-nopathic Gaucher disease.
    Version of Record
    Insight
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Development: Shining a light on hematopoietic stem cells

    Anne Schmidt
    A combination of light and electron microscopy has revealed further details about the location and interactions of hematopoietic stem and progenitor cells.
    Version of Record
    Insight
    1. Computational and Systems Biology
    2. Ecology

    Fermentation: Teaming up to make kombucha

    Olga Ponomarova
    Reducing the microbial diversity in a type of fermented tea reveals the core metabolic interactions responsible for the drink’s signature taste and characteristics.
    Version of Record
    Insight
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution: Poor eyesight reveals a new vision gene

    Tathagata Biswas, Jaya Krishnan, Nicolas Rohner
    Comparing the genomes of mammals which evolved to have poor vision identifies an important gene for eyesight.
    Version of Record
    Insight
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Adaptive Immunity: Maintaining naivety of T cells

    Ken Duffy
    Mathematical models encoding biological hypotheses reveal new insight into the dynamics of naive immune cells in mice from birth to old age.
    Version of Record
    Insight
    1. Neuroscience

    Brain: Connecting the lines after a stroke

    S Thomas Carmichael
    In mice, stimulating cortical areas in the undamaged hemisphere of a brain affected by stroke impairs recovery.
    Version of Record
    Insight
    1. Cell Biology

    Cell Mechanics: Under the hood of a moving cell

    Guillaume Romet-Lemonne
    Experiments using purified proteins reveal how the network of filaments that underlie cell movement becomes denser when pushing against a stronger mechanical force.
    Version of Record
    Insight
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Protease Inhibitors: Developing evolution-resistant drugs for COVID-19

    Daniel M Weinreich
    Analyzing how mutations affect the main protease of SARS-CoV-2 may help researchers develop drugs that are effective against current and future variants of the virus.
    Version of Record
    Insight