A combination of electrophysiology and quantitative modeling shows that subtle changes in input due to adaptation in cone phototransduction control the linearity or nonlinearity of how ganglion cells integrate spatial inputs.
A cargo recognition α-helix was identified in Nup358, which is required for activation of a dynein-dependent transport pathway that is essential for brain development.
The general transcription factor TFIIH complex promotes the establishment and maintenance of chromosome structure during mitosis by altering the chromatin environment to allow for proper loading and function of the condensin complexes on chromatin.
Giulia Di Felice, Giovanni Visci ... Paolo Boffetta
A twofold increased risk of adverse outcomes (mortality, ICU admission, and severity of COVID-19) has been demonstrated in unvaccinated COVID-19 patients with cancer compared to COVID-19 patients without cancer.
Physiological and biochemical studies show that the treatment of a transgenic mouse model carrying recessive Ryr1 mutations with a combination of class II histone deacetylase inhibitors and DNA methyl transferase inhibitors significantly improves skeletal muscle function.
Experience alters neurotransmitter release from different axonal compartments in different ways, allowing a set of neurons to coherently modulate behavior through diverse actions on multiple downstream circuits.
Karthik Shekhar, Irene E Whitney ... Joshua R Sanes
Single-cell transcriptomic analysis of developing retinal ganglion cells in mice suggests that their diversification into 45 discrete types occurs via the gradual restriction of multipotential precursors.
STIM1 regulates the contractility of blood vessels and blood pressure by organizing membrane contact sites and ion channel activity in vascular smooth muscle cells in a manner that is independent of its canonical function in store-operated Ca2+entry.
