October 2013

Research articles

    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

    Jingtao Lilue et al
    Mechanisms that enable wild mice to survive infection with strains of the Toxoplasma gondii parasite virulent enough to kill laboratory mice offer an explanation for how these parasites have been able to persist in the mouse population.
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    1. Biochemistry

    Global cellular response to chemotherapy-induced apoptosis

    Arun P Wiita et al
    The simultaneous monitoring of transcription, translational control, protein production and proteolysis in the same system can improve our understanding of how cancer cells respond to chemotherapy.
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    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

    István Bartha et al
    An innovative strategy in genome analysis has generated a detailed description of how pathogens mutate when facing human genetic diversity.
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    1. Genes and Chromosomes

    Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

    Liou Y Sun et al
    Mice with a mutation that disrupts the release of growth hormone show greatly increased lifespan, which can be further increased by caloric restriction.
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    1. Genes and Chromosomes

    Engineered proteins detect spontaneous DNA breakage in human and bacterial cells

    Chandan Shee et al
    Fluorescent derivatives of a bacteriophage protein that binds double-stranded ends can trap and label genome-destabilizing double-strand DNA breaks in bacterial and human cells, and illuminate the origins of spontaneous DNA breakage in both.
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

    Sigrid Nachtergaele et al
    A cysteine-rich domain within the Smoothened receptor may represent a novel therapeutic target for cancers caused by abnormal functioning of the Hedgehog signaling pathway.
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    1. Human Biology and Medicine

    Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

    Vitor H Teixeira et al
    Cell replenishment within the airways is governed by the random division of a population of basal progenitor cells, in a process that is accelerated in smokers.
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    1. Neuroscience

    Conceptual metaphorical mapping in chimpanzees (Pan troglodytes)

    Christoph D Dahl, Ikuma Adachi
    The use of metaphorical concepts is not unique to humans.
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    1. Biochemistry
    2. Genes and Chromosomes

    Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion

    Meghan M McLean et al
    The structure of the recombination complex responsible for flagellar antigen switching in Salmonella enterica, and the mechanism that regulates the site-specific DNA inversion reaction, have been determined.
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    1. Ecology
    2. Microbiology and Infectious Disease

    A microbial clock provides an accurate estimate of the postmortem interval in a mouse model system

    Jessica L Metcalf et al
    High-throughput sequencing has been used to analyze the microbiome of mouse corpses over a period of 48 days, and to provide an accurate estimate of the time since death.
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    1. Developmental Biology and Stem Cells

    Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

    Yunyun Jin et al
    The Brahma chromatin remodelling complex interacts with the Hippo signalling pathway to regulate the proliferation and differentiation of stem cells in the Drosophila midgut.
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    1. Genes and Chromosomes

    A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis

    Virginie Olive et al
    While intact mir-17-92 acts as a potent oncogene in a mouse model of Burkitt’s lymphoma, one of the six mir-17-92 components antagonizes its oncogenic cooperation with c-Myc by promoting c-Myc-induced apoptosis.
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    1. Biophysics and Structural Biology
    2. Cell Biology

    Nanoscale protein architecture of the kidney glomerular basement membrane

    Hani Suleiman et al
    High-resolution optical microscopy is used to reveal the organization of extracellular matrix proteins within the basement membrane of the blood filtration barrier in the kidney at the nanometer scale.
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    1. Biophysics and Structural Biology
    2. Cell Biology

    Slo1 is the principal potassium channel of human spermatozoa

    Nadja Mannowetz et al
    Potassium ions enter and leave human sperm cells via a calcium-dependent ion channel that is also pH-independent.
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    1. Biochemistry
    2. Biophysics and Structural Biology

    A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

    Franziska Bleichert et al
    Electron microscopy uncovers the structure of the origin recognition complex (ORC) in metazoans, and reveals how mutations in the ORC6 subunit lead to Meier-Gorlin syndrome in humans.
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    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

    Alyson Ashe et al
    Evidence that C. elegans and mammals use homologous versions of the same protein (RIG-1) to activate antiviral defense mechanisms suggests that RIG-1 may have a conserved role in coupling virus recognition to virus destruction.
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    1. Genomics and Evolutionary Biology
    2. Plant Biology

    Cytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome

    Bindu Joseph et al
    Genes located within cellular organelles impact phenotype more than expected due to their interactions with nuclear genes.
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