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Page 966 of 1,744
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Alternative splicing of coq-2 controls the levels of rhodoquinone in animals

    June H Tan, Margot Lautens ... Gustavo Salinas
    The switch from ubiquinone to rhodoquinone synthesis that is required for parasitic helminths to survive in anaerobic host tissues is due to alternative splicing of polyprenyltransferase COQ-2.
    1. Immunology and Inflammation
    2. Neuroscience

    Drainage of inflammatory macromolecules from the brain to periphery targets the liver for macrophage infiltration

    Linlin Yang, Jessica A Jiménez ... Celia E Shiau
    Circulation of molecules from the brain can serve as a rapid mode of communication from the brain to the liver.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

    Chongyuan Wang, Agata Jacewicz ... Stephen Barstow Long
    Cryo-EM structures reveal that MICU1-MICU2 operates like a regulatable toxin to block the pore of the mitochondrial calcium uniporter and confer Ca2+-dependent control.
    1. Epidemiology and Global Health
    2. Medicine

    A systematic review of population-based studies on lipid profiles in Latin America and the Caribbean

    Rodrigo M Carrillo-Larco, C Joel Benites-Moya ... Antonio Bernabe-Ortiz
    In Latin America and the Caribbean the most common dyslipidaemia seems to be low HDL-cholesterol, and there has been little change in time for both mean levels and prevalence estimates.
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati, Marcela de Souza Santos ... Kim Orth
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.
    1. Developmental Biology

    TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex

    Dario Zimmerli, Costanza Borrelli ... Claudio Cantù
    The developmental transcription factor TBX3 co-operates with β-catenin co-factors to operate tissue-specific transcriptional outputs, during forelimb development and colorectal cancer progression.
    1. Chromosomes and Gene Expression

    Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner

    Juan Lafuente-Barquero, Maria Luisa García-Rubio ... Andrés Aguilera
    RNA does not form DNA:RNA hybrids in trans that compromise genome integrity.
    1. Neuroscience
    2. Physics of Living Systems

    Revealing architectural order with quantitative label-free imaging and deep learning

    Syuan-Ming Guo, Li-Hao Yeh ... Shalin B Mehta
    Advances in quantitative phase and polarized light microscopy, combined with deep learning, reveal the architecture of human brain tissue.
    1. Developmental Biology

    Intrinsic control of muscle attachment sites matching

    Alexandre Carayon, Laetitia Bataillé ... Jean-Louis Frendo
    Making a link between deletion of transcription cis-regulatory elements by CrispR/Cas9, obtention of mutants with single muscle morphology defects and their impact on locomotion.
    1. Ecology
    2. Evolutionary Biology

    Temperature stress induces mites to help their carrion beetle hosts by eliminating rival blowflies

    Syuan-Jyun Sun, Rebecca M Kilner
    Temperature, the presence of an enemy species and the density of the mutualistic partner species interact to determine the expression of a protective mutualism.