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A large observational study has found that irregular sleep-wake patterns are associated with a higher risk of overall mortality, and also mortality from cancers and cardiovascular disease.

Imaging experiments reveal the complex and dynamic nature of the transcriptional hubs associated with Notch signaling.

A receptor protein called TGN46 has an important role in sorting secretory proteins into vesicles going to different destinations inside cells.

A strategy to identify high-quality commercially available antibodies for research reveals extensive use of non-specific antibodies and offers solutions for future large-scale testing.

Neurons that transmit information from the retina to other parts of the brain are more affected by anesthesia than previously thought.

A new computational tool provides insights into the structure of the cerebellum in mammals.

It may be possible to treat cardiac hypertrophy and injury by using drugs that inhibit a protein called SIRT2.

A genetic duplication event during evolution allowed male wood tiger moths to have either yellow or white patterns on their wings.

A molecular pathway involving compounds found in processed foods and biogenic amines increases food intake and aging in the roundworm C. elegans.

Gene expression profiling of a diverse mouse population helps to decipher how a fat-rich diet contributes to inflammatory bowel disease.