Browse our Research Articles

Page 422 of 1,394
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism

    Damon JA Frampton, Koushik Choudhury ... Sara I Liin
    Polyunsaturated fatty acids facilitate or impede Kv7 channel activation, depending on channel subtype and their dominant functional site(s).
    1. Cell Biology

    Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

    Albert Pérez-Martí, Suresh Ramakrishnan ... Matias Simons
    Monounsaturated fatty acids protect against DKD by enhancing membrane fluidity and decreasing ER lipid bilayer stress in renal proximal tubules.
    1. Physics of Living Systems

    Glycan processing in the Golgi as optimal information coding that constrains cisternal number and enzyme specificity

    Alkesh Yadav, Quentin Vagne ... Madan Rao
    A mathematical model of glycosylation in the Golgi apparatus to investigate how the fidelity of synthesising a complex glycan distribution at the plasma membrane depends on parameters such as the number of Golgi cisternae or enzyme specificity.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Osteogenic growth peptide is a potent anti-inflammatory and bone preserving hormone via cannabinoid receptor type 2

    Bitya Raphael-Mizrahi, Malka Attar-Namdar ... Yankel Gabet
    Osteogenic growth peptide displays agonistic activity at CB2.
    1. Genetics and Genomics
    2. Neuroscience

    A persistent behavioral state enables sustained predation of humans by mosquitoes

    Trevor R Sorrells, Anjali Pandey ... Leslie B Vosshall
    Brief fictive carbon dioxide sensation induced by optogenetics in the female mosquito induces long-lasting arousal and probing, explaining the persistent predatory behavior of this dangerous disease-vectoring insect.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration

    Giacomo L Glotzer, Pietro Tardivo, Elly M Tanaka
    Although many Apical Ectodermal Ridge signaling components are found in the axolotl limb epidermis, responsiveness to canonical Wnt signaling has shifted to the limb mesenchyme where it regulates mesenchymal Fgf8 expression.
    1. Cancer Biology
    2. Cell Biology

    Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

    Edward Fielder, Tengfei Wan ... Satomi Miwa
    Late effects of radiation therapy in mice can be prevented by treatment with either senolytics navitoclax or quercetin plus dasatinib or the senostatic metformin.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    High-intensity interval training remodels the proteome and acetylome of human skeletal muscle

    Morten Hostrup, Anders Krogh Lemminger ... Atul Shahaji Deshmukh
    Global proteomic and acetylomic analyses reveal how skeletal muscle adapts to high-intensity interval training including adaptations to processes regulating metabolism and contraction.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

    Brianna Bibel, Elad Elkayam ... Leemor Joshua-Tor
    The central RNA interference protein, human Argonaute-2, releases its target following phosphorylation on a critical loop in the protein, freeing microRNA-bound Argonaute-2 to seek out and repress additional targets.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Male rat leukocyte population dynamics predict a window for intervention in aging

    Hagai Yanai, Christopher Dunn ... Isabel Beerman
    Rat blood profiles support non-linear aging with distinct trajectory shifts, and these profiles could be used to predict non-overt illness in rats or aging intervention efficacy.