Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article

  • Mechanics of oncogenesis

    Integrative mechanobiological approaches provide insight into the biophysics of tissue-specific tumor growth.

    Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
    Research Article

  • Signals for retinal development

    Synchronous waves of activity in the developing retina of postnatal mice potentially involve purinergic signalling triggered by apoptotic retinal ganglia.

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    Reviewed Preprint Updated

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • Hippocampal memory

    Genetic evidence highlights the roles of atypical protein kinase C isoforms in hippocampal late-phase long-term potentiation and long-term memory.

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
    Research Advance

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The bile acid receptor TGR5 is a modulator of bone marrow adipose tissue and the hematopoietic niche

    Alejandro Alonso-Calleja, Alessia Perino ... Olaia Naveiras
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience

    EEG-Neurofeedback Targeting Gamma Oscillations at the Parieto-Occipital Region Reduces Pain Perception

    Xiangyue Zhao, Hao Sun ... Li Hu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Multisensory learning recruits visual neurons into an olfactory memory engram

    Zeynep Okray, Nils Otto ... Scott Waddell
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Physiology

    mTOR regulates longevity through a bile-acid like hormonal mechanism and DHS-26/DHRS1

    Klara Schilling, Alex Zaufel ... Adam Antebi
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Reduced dorsal CA1 Activity Limits Retention of the Temporal Component of Declarative Memory in the Cntnap2 Knockout Mouse Model of Autism

    Elise C Rawlinson, Michael H McCullough ... Nathalie Dehorter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Inhibiting the interaction between the mitochondrial receptor Tom70 and SARS CoV 2 Orf9b with small molecules

    CJ San Felipe, Kliment A Verba ... James S Fraser
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Ecology

    Small mammalian herbivores at moderate densities facilitate livestock growth by improving vegetation composition in grasslands

    Zhiwei Zhong, Bingbo Ni ... Zhibin Zhang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Revealing the benefit of eye motion for acuity under emulated cone loss

    Hannah K Doyle, James Fong ... Austin Roorda
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology

    Polo-like kinase phosphorylation of the orphan kinesin KIN-G negatively regulates centrin arm biogenesis in Trypanosoma brucei

    Yasuhiro Kurasawa, Qing Zhou ... Ziyin Li
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Strong mnemonic prediction errors increase cognitive control, attention, and arousal

    Alice M Xue, Jenna Jokhani ... Anthony D Wagner
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
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Magazine

    1. Cell Biology

    Stress: How to give cells an identity crisis

    Paige Dillon, Julie Hollien
    1. Epidemiology and Global Health

    Malaria Prevention: Using mathematical models to optimise mosquito net distribution

    Carlos A Prete Jr
    1. Plant Biology

    Mixotrophy: An updated view of glucose pathways in cyanobacteria

    José Manuel García-Fernández
  4. Mountain gorilla

    Episode 104: July 2026

    1. Cell Biology
    2. Developmental Biology

    Organ Development: Following your heart as it takes shape

    Alexandra Trouilloud, Nicole C Dubois
    1. Cancer Biology

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    1. Neuroscience

    Brain Mapping: Understanding the cellular architecture of Huntington’s disease

    Dorian Pustina
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
  17. Plant Biology
  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
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