Highlights

  • Mapping regulatory DNA

    Cis-regulatory elements in the large genome of Parhyale hawaiensis can be identified by integrating chromatin accessibility and sequence conservation data.

    Gillian Forbes, Emilia Skafida ... Mathilde Paris
    Research Article
  • Hypoxia to healthspan

    Genetic tools highlight potential signalling components underlying hypoxia-induced longevity in C. elegans.

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Reviewed Preprint Updated
  • Symbionts shape pest traits

    Novel endosymbiotic bacteria have contrasting effects on the performance and dispersal of Russian wheat aphids and on the severity of damage caused to cereal host plants.

    Xinyue Gu, Alex Gill ... Ary A Hoffmann
    Reviewed Preprint
  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial
  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife
  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article

Latest research

    1. Genetics and Genomics

    Dietary Restriction Impacts Peripheral Diurnal Rhythms Important for Longevity in Drosophila

    Dae-Sung Hwangbo, Yong-Jae Kwon ... Ravi Allada
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Incomplete
    1. Neuroscience

    Limitations of pupil diameter as a proxy for modes of locus coeruleus activity

    Lowell W Thompson, Joshua I Gold
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Neurofeedback enhances a neural signature of selective attention to speech in cocktail-party settings

    Ram K Pari, Marina Inyutina ... Benedikt Zoefel
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Reassessing Choice Probability: What 59 Macaque Studies Tell Us About Decision-Related Activity in Visual Cortex

    Anton Pletenev, Richard T Born ... Ralf M Haefner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    Light-entrained chromatin priming poises rapid metamorphosis in a marine sponge

    Huifang Yuan, Oceane Blard ... Sandie M Degnan
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice

    Chi-Hong Wu, Gina G Turrigiano
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Microbiology and Infectious Disease

    A novel mechanism for morphological change during bacterial sporulation based on programmed peptidoglycan degradation

    Carlos A Ramírez Carbó, Oihane Irazoki ... Beiyan Nan
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Neuroscience

    Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions

    Tien Phuoc Tran, Bogdan Budnik ... Jeffrey D Macklis
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Listening to the room: disrupting activity of dorsolateral prefrontal cortex impairs learning of room acoustics in human listeners

    Heivet Hernández-Pérez, Jessica JM Monaghan ... David McAlpine
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Mapping the topographic organization of the human zona incerta using diffusion MRI

    Roy AM Haast, Jason Kai ... Jonathan C Lau
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling