Highlights

  • Complex connections

    Optogenetics reveals that interactions between the basal ganglia and the pedunculopontine nucleus (PPN), a region that has a central role in motor control, are more complex than previously thought.

    Michel Fallah, Kenea C Udobi ... Rebekah C Evans
    Research Article
  • The benefits of disorder

    The presence of an intrinsically disordered region in a transcription factor enhances both target binding and search efficiency.

    Wencheng Ji, Ori Hachmo ... Ariel Amir
    Reviewed Preprint Updated
  • Early influences on cell fate

    Cells that polarize early during the 8-cell stage of development in mouse embryos are more likely to become part of the placenta.

    Adiyant Lamba, Meng Zhu ... Magdalena Zernicka-Goetz
    Reviewed Preprint Updated

Latest research

    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Restoring data balance via generative models of T cell receptors for antigen-binding prediction

    Emanuele Loffredo, Mauro Pastore ... Rémi Monasson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Observational activation of anterior cingulate cortical neurons coordinates hippocampal replay in social learning

    Xiang Mou, Daoyun Ji
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Epidemiology and Global Health

    Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study

    Fernanda Morales-Berstein, Jasmine Khouja ... Rebecca C Richmond
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    The TTLL10 polyglycylase is stimulated by tubulin glutamylation and inhibited by polyglycylation

    Steven W Cummings, Yan Li ... Antonina Roll-Mecak
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    • Compelling
    1. Neuroscience

    Spatially Periodic Computation in the Entorhinal-Hippocampal Circuit During Navigation

    Bo Zhang, Xin Guan ... Jia Liu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Orderly mitosis shapes interphase genome architecture

    Krishnendu Guin, Adib Keikhosravi ... Tom Misteli
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Physics of Living Systems

    Transport kinetics across interfaces between coexisting liquid phases

    Lars Hubatsch, Stefano Bo ... Frank Jülicher
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity

    Hiroki Toyoda, Doyun Kim ... Youngnam Kang
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
    1. Developmental Biology
    2. Neuroscience

    Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function

    Caleb CS Calhoun, Mary ES Capps ... Summer B Thyme
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cancer Biology

    SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation

    Ricardo J Mack, Natasha M Flores ... Or Gozani
    Genetic and biochemical studies show that SETD2 is tumor suppressive in a lung cancer mouse model and SETD2 methylation activity in vitro is regulated by histone acetylation.