Highlights

  • Getting ready to open

    Clusters of synapses develop in the primary visual cortex in young mice before they open their eyes for the first time.

    Alexandra H Leighton, Juliette E Cheyne, Christian Lohmann
    Research Article
  • Spontaneous preterm birth

    Measuring proteins involved in the immune response in pregnant women may help to identify those at risk of spontaneous preterm birth.

    Zachary Shaffer, Roberto Romero ... Nardhy Gomez-Lopez
    Research Article
  • Decoding spike signatures

    Nuclei cells in the cerebellum produce distinct spike signatures for ataxia, dystonia, and tremor in mouse models.

    Meike E. van der Heijden, Amanda M. Brown ... Roy V. Sillitoe
    Reviewed Preprint Updated

Latest research

    1. Computational and Systems Biology
    2. Genetics and Genomics

    Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank

    Ardalan Naseri, Degui Zhi, Shaojie Zhang
    ROH-DICE is an efficient method for detecting ROH clusters in biobank data, enabling the study of population history of large cohorts, and providing a new genome-wide association analysis approach for finding disease-causing loci with multi-marker recessive effects.
    1. Neuroscience

    Glutamate neurotransmission from leptin receptor cells is required for typical puberty and reproductive function in female mice

    Cristina Sáenz de Miera, Nicole Bellefontaine ... Carol F Elias
    Glutamate neurotransmission from hypothalamic ventral premammillary nucleus is indispensable for leptin action in pubertal development and typical reproduction.
    1. Medicine

    An atlas of brain-bone sympathetic neural circuits in mice

    Vitaly Ryu, Anisa Azatovna Gumerova ... Mone Zaidi
    Central SNS outflow sites originating from 87 brain nuclei and sub-nuclei in six brain divisions innervate bone.
    1. Cell Biology

    Vacuolar H+-ATPase determines daughter cell fates through asymmetric segregation of the nucleosome remodeling and deacetylase complex

    Zhongyun Xie, Yongping Chai ... Wei Li
    Asymmetric segregation of V-ATPase may cause distinct acidification levels in the two daughter cells, enabling asymmetric epigenetic inheritance that specifies their respective life-versus-death fates.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals

    Lisa Baumgartner, Jonathan J Ipsaro ... Julius Brennecke
    Genetic and biochemical characterization reveals how a single amino acid change in the chromodomain of the HP1 protein Rhino enables its specific interaction with the guidance factor Kipferl.