Highlights

  • ITP signaling and homeostasis

    The ion transport peptide (ITP) signaling system relies on a guanylate cyclase receptor to maintain homeostasis in Drosophila.

    Jayati Gera, Marishia Agard ... Meet Zandawala
    Research Article

  • Focus Issue: Trained Immunity

    The articles in this focus issue discuss progress towards a better understanding of memory in the innate immune system, and efforts to develop new vaccines and therapeutics based on “trained immunity”.

    Collection

  • Phosphate buffering

    Lysosome-related vacuoles control the metabolism of inorganic polyphosphates to stabilize the concentration of phosphate in the cytosol.

    Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
    Research Article

  • How we understand each other

    eLife author Joe Barnby answers questions about a study that explored how humans navigate social interactions.

    Inside eLife

  • No change for astroctyes

    Genetically removing the RNA-binding protein PTBP1 from astrocytes does not convert them into neurons, contrary to previous claims.

    Min Zhang, Naoto Kubota ... Sika Zheng
    Research Article

  • Drug-resistant sleeping sickness

    Mutations in a water channel called TbAQP2 make the parasite that causes sleeping sickness resistant to drugs. Image: Jessica Eggers (CC BY 4.0).

    Modestas Matusevicius, Robin A Corey ... Simone N Weyand
    Reviewed Preprint Updated
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Frequency-selective contrast sensitivity modulation driven by fine-tuned exogenous attention at the foveal scale

    Yue Guzhang, T Florian Jaeger, Martina Poletti
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice

    Chi-Hong Wu, Gina G Turrigiano
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A modular platform to display multiple hemagglutinin subtypes on a single immunogen

    Dana Thornlow Lamson, Faez Amokrane Nait Mohamed ... Aaron G Schmidt
    BOAS is a platform for building multivalent viral protein immunogens without a scaffold, such as a nanoparticle, to elicit broad influenza vaccine responses.
    1. Biochemistry and Chemical Biology

    Deep learning reveals endogenous sterols as allosteric modulators of the GPCR–Gα interface

    Sanjay Kumar Mohanty, Aayushi Mittal ... Gaurav Ahuja
    An AI-driven computational toolkit, Gcoupler, integrates ligand design, statistical modeling, and graph neural networks to predict endogenous metabolites that allosterically modulate the GPCR–Gα interface and regulate downstream signaling.
    1. Developmental Biology

    Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification

    Adiyant Lamba, Meng Zhu ... Magdalena Zernicka-Goetz
    Mouse embryo cells undergo apical-basal polarization asynchronously at the 8-cell stage, and the timing of polarization influences subsequent lineage allocation.
    1. Physics of Living Systems

    Theory of active self-organization of dense nematic structures in the actin cytoskeleton

    Waleed Mirza, Marco De Corato ... Marino Arroyo
    Theoretical and computational modeling reveals a mechanism of active patterning of uniform isotropic actin gels into dense nematic bundles, providing a physical basis for the adaptability of the actin cytoskeleton.
    1. Microbiology and Infectious Disease

    PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment

    Binayak Sarkar, Jyotsna Singh ... Rajesh S Gokhale
    In vitro, ex vivo, and in vivo studies reveal that hepatocytes are significantly infected by Mycobacterium tuberculosis which rewires the host cell metabolism to upregulate the lipid biosynthetic pathways.
    1. Neuroscience

    Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

    HiJee Kang, Travis A Babola, Patrick O Kanold
    Holographic neuronal stimulation shows that auditory cortex neurons with shared functional properties rapidly adjust their responses during sensory processing, revealing a circuit-level mechanism that regulates overall network activity balance.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Serratia marcescens Outer Membrane Vesicles rapidly paralyze Drosophila melanogaster through triggering apoptosis in the nervous system

    Bechara Sina Rahme, Roberto E Bruna ... Dominique Ferrandon
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Cancer Biology
    2. Evolutionary Biology

    Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

    Christopher Graser, Wenbo Wu ... Franziska Michor
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
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Magazine

    1. Microbiology and Infectious Disease

    Tuberculosis: A surprising new hiding place for a dangerous pathogen

    Sheetal Gandotra, Yogendra Singh
  2. Blurry photo of a flag, fish and a bird in the water

    Episode 101: December 2025

    1. Neuroscience

    Neuronal Activity: Keeping track of moving targets

    Renata Batista-Brito, Geoffrey Terral

  4. Research Culture: The SAFE Labs Handbook as a tool for improving lab culture

    Erika Donà, James M Gahan ... Philip Coen
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Genetics and Genomics

    Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

    Lesley T MacNeil
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
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  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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