Highlights

Latest research

    1. Neuroscience

    Binary and analog variation of synapses between cortical pyramidal neurons

    Sven Dorkenwald, Nicholas L Turner ... H Sebastian Seung
    Sizes of synapses between layer 2/3 pyramidal cells in mouse primary visual cortex are well modeled by the sum of a binary variable and an analog variable drawn from a log-normal distribution.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Taxonium, a web-based tool for exploring large phylogenetic trees

    Theo Sanderson
    A new tool allows researchers to dive into phylogenetic trees containing millions of nodes using just their web browser.
    1. Developmental Biology
    2. Genetics and Genomics

    Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models

    Suhee Chang, Diana Fulmer ... Marisa S Bartolomei
    Precise dosage of the imprinted H19 and Igf2 genes is critical for normal embryonic development, especially related to the cardiac-placental axis.
    1. Structural Biology and Molecular Biophysics

    Sublytic gasdermin-D pores captured in atomistic molecular simulations

    Stefan L Schaefer, Gerhard Hummer
    Molecular dynamics simulations reveal the formation of membrane pores by gasdermin-D, the ultimate effector of pyroptotic cell death in inflammation and infection.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X

    Jinli Geng, Yingjun Tang ... Xiaodong Liu
    Focusing on calcium oscillations in relation to neuronal morphology both in vitro and in vivo, rationally designed GCaMP-X provides a simple solution to neuronal toxicity of conventional GCaMP in imaging applications involving prolonged and/or strong expression of calcium probes.
    1. Neuroscience

    Dorsal striatum coding for the timely execution of action sequences

    Maria Cecilia Martinez, Camila Lidia Zold ... Mariano Andrés Belluscio
    In adolescent rats, whose actions are more impulsive, neuronal striatal activity that precedes self-initiated action sequences has a steeper modulation by waiting time compared to the modulation found in adults.
    1. Immunology and Inflammation

    Cell-intrinsic ceramides determine T cell function during melanoma progression

    Matthias Hose, Anne Günther ... Wiebke Hansen
    Cell-intrinsic ceramide concentrations are involved in T cell differentiation and function.
    1. Cancer Biology
    2. Medicine

    Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review

    Huan-Huan Chen, Tie-Ning Zhang ... Tao Zhang
    Non-coding RNAs appear to be good candidates as biomarkers for predicting treatment response and therapeutics for sarcoma, their differential expression across tissues complicates their application.