Highlights

We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Applying functional MRI analysis techniques to whole-brain calcium-imaging data to investigate structural and functional relationships in Drosophila melanogaster

    Takuto Okuno, Alexander Woodward ... Junichi Hata
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    Unique longitudinal contributions of sulcal interruptions to reading acquisition in children

    Florence Bouhali, Jessica Dubois ... Kevin S Weiner
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Whole-brain mapping of spinal-projecting neurons in larval zebrafish

    Martin Carbo-Tano, Kevin Fidelin ... Claire Wyart
    The supraspinal system of larval zebrafish has been described, uncovering spinal projections from the telencephalon, mesencephalon, and rhombencephalon, as well as numerous motor and neuromodulatory nuclei conserved with mammals.
    1. Biochemistry and Chemical Biology

    Lateral opening site of human oligopeptide transporter 2 plays a key role in the interaction with polymyxins

    Xukai Jiang, Yining Luo ... Jian Li
    Mapping the molecular interactions between polymyxins and hPepT2 enables rational design of safer lipopeptide antibiotics with reduced renal toxicity while retaining antibacterial activity.
    1. Neuroscience

    Revealing the benefit of eye motion for acuity under emulated cone loss

    Hannah K Doyle, James Fong ... Austin Roorda
    In the presence of emulated cone loss, eye movements are used to gather and integrate information, leading to improved letter acuity compared to a non-moving condition.
    1. Cancer Biology
    2. Cell Biology

    Molecular and functional analysis of calcium binding by a cancer-linked calreticulin mutant

    Ishmael Nii Ayibontey Tagoe, Amanpreet Kaur ... Malini Raghavan
    Endoplasmic reticulum and cytosolic calcium levels, and store-operated calcium entry, are comparable in calreticulin-deficient cells rescued with either wild-type calreticulin or the myeloproliferative neoplasm-linked Del52 mutant.
    1. Immunology and Inflammation

    Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling

    Sung Hoon Cho, Shawna K Brookens ... Mark R Boothby
    Genetic and biochemical analyses reveal a way to overcome the metabolic flexibility of B cells and undermine their cytokine receptor signaling and differentiation into antibody-secreting cells, therapeutic targets in systemic lupus erythematosus (SLE).
    1. Structural Biology and Molecular Biophysics

    Yoda molecules agonize PIEZO2

    Tharaka D Wijerathne, Aneesh Chandrasekharan ... Jérôme J Lacroix
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    RHODOPSIN 7: An ancestral non-canonical photoreceptor shaping light-responsive behavior

    Valentina Kirsch, Nils Reinhard ... Pingkalai R Senthilan
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania

    Gabriel H Negreira, Pieter Monsieurs ... Malgorzata A Domagalska
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
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Magazine

    1. Cell Biology
    2. Physiology

    Mechanosensory Physiology: Lymphatic vessels under pressure

    Asser F Bedair, Osama F Harraz
    1. Epidemiology and Global Health

    Science Forum: The new paradox of women’s health research

    Ursula Debarnot, Alexandre Fouré
    1. Genetics and Genomics
    2. Physiology

    Steroid Signaling: A hormonal message for a longer life

    Kyle Feola, Peter M Douglas
    1. Microbiology and Infectious Disease

    Bird Flu: The cow udder as an influenza mixing ground

    Silke Rimaux, Robert P de Vries
    1. Computational and Systems Biology

    AI in Science: The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    1. Genetics and Genomics
    2. Developmental Biology
    grid of multicoloured bar graphs with vertical shaded areas in red and green highlighting specific columns

    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  7. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
  17. Plant Biology
  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
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