Highlights

We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination

    Marc E Normandin, Pedro M Ogallar ... Isabel A Muzzio
    Stable and dynamic prelimbic neurons preserve threat-generalization gradients despite ensemble turnover, supporting enduring representations of stimulus significance rather than freezing.
    1. Neuroscience

    A mechanistic theory of planning in prefrontal cortex

    Kristopher T Jensen, Peter T Doohan ... Timothy E Behrens
    Recently discovered sequence representations in prefrontal cortex can be combined with the ubiquitous principle of neural attractor dynamics to support planning in complex environments.
    1. Immunology and Inflammation

    Role of gut epithelial-cell derived transglutaminase 2 in the formation of celiac disease autoantibodies

    Runa I Løberg, Helena A Abdi-Dezfuli ... M Fleur du Pré
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    An integrated human forebrain organoid reveals microglia-mediated CD8+ T cell recruitment and neuroimmune dysfunction in Alzheimer’s disease pathology

    Yilin Feng, Feifei Yu ... Shaohua Ma
    Human forebrain organoids reveal that amyloid-driven microglia recruit killer T cells via CCL5, forming a self-amplifying neuroinflammatory loop targetable by CCR5 or CXCR3 blockade.
    1. Neuroscience

    Multiplexed CRISPRi reveals a transcriptional switch between KLF activators and repressors in the maturing neocortex

    Ryan W Kirk, Liwei Sun ... Sacha B Nelson
    In mammalian neocortex, opposing Krüppel-like factor (KLF) transcription factors first activate and then repress a genetic program related to axon outgrowth, potentially contributing to loss of cortical axon outgrowth in the adult.
    1. Cell Biology

    The microtubule-associated proteins CKAP2 and its paralog CKAP2-Like control ciliogenesis in human cells

    Luiz E da Silva, Gabriel Campolina-Silva ... Susanne Bechstedt
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience

    A reinforcement learning framework for goal-directed stimulation of engineered neuronal networks

    Benedikt Maurer, Vaiva Vasiliauskaitė ... Stephan J Ihle
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Theta phase and theta-gamma coupling organise the spoken language network

    Haya Akkad, Daniel Bush ... Jenny Crinion
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology
    2. Genetics and Genomics

    Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

    Kuei Ching Hsiung, Hannah Chapman ... David Gems
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Immunology and Inflammation

    Syntaxin11 deficiency inhibits CRAC channel priming to suppress cytotoxicity and gene expression in T lymphocytes independent of membrane trafficking

    Sritama Datta, Abhikarsh Gupta ... Monika Vig
    Syntaxin11 directly controls a novel step in the activation of calcium channels, which helps activate genes and kill infected cells by a process distinct from moving cargo inside cells.
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Magazine

    1. Microbiology and Infectious Disease

    Bird Flu: The cow udder as an influenza mixing ground

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    1. Computational and Systems Biology

    AI in Science: The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    1. Genetics and Genomics
    2. Developmental Biology
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    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

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    1. Cell Biology
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    Philosophy of Biology: The power of theory in the life sciences

    Jacob L Fine, Finn Creeggan ... Adam MR Groh
    1. Genetics and Genomics

    Environmental Learning: How experience shapes individuality

    Bassem A Hassan
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Categories

  1. Biochemistry and Chemical Biology
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  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
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