Latest research

1. 1. Microbiology and Infectious Disease

   Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection

   Karthik Hullahalli, Matthew K Waldor

   During Escherichia coli systemic infection, the replication of a minuscule fraction of the inoculum drives organ-specific clearance failures, systemic dissemination, and stochastic infection outcomes.
2. 1. Neuroscience

   Learning differentially shapes prefrontal and hippocampal activity during classical conditioning

   Jan L Klee et al.

   CA1 and PFC bridge the temporal gap between cue and reward delivery during trace conditioning according to different underlying coding principles and task-related activity is reactivated during awake Sharp-Wave Ripples.
3. 1. Physics of Living Systems
   2. Structural Biology and Molecular Biophysics

   Multicolor fluorescence fluctuation spectroscopy in living cells via spectral detection

   Valentin Dunsing et al.

   Fluorescence fluctuation spectroscopy is implemented for detection of up to four molecular species, allowing users to quantify molecular interactions and stoichiometry of multicomponent complexes in live cells, in a wide range of biological processes, from membrane signaling to viral assembly.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

   Jason Neidleman et al.

   COVID-19 mRNA vaccine-elicited T cells recognize variants of concern and phenotypically differ depending on number of vaccine doses and prior SARS-CoV-2 infection status.
5. 1. Cell Biology

   Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease

   Julia Sánchez-Ceinos et al.

   Alternative splicing and the endoplasmic reticulum (ER)-associated protein degradation (ERAD) system represent essential, fat depot-specific components of the adipogenesis that are altered in preadipocytes from obese individuals with metabolic disease.
6. 1. Cell Biology
   2. Microbiology and Infectious Disease

   The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle

   Deike J Omnus et al.

   A proteomics-based approach identifies novel substrate proteins of the Lon protease in Caulobacter crescentus and reveals a critical role of Lon in regulating flagella assembly and stalk biogenesis during the cell cycle.
7. 1. Neuroscience

   Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum

   Peter H Chipman et al.
8. 1. Microbiology and Infectious Disease

   Effect of SARS-CoV-2 proteins on vascular permeability

   Rossana Rauti et al.

   A specific SARS-CoV-2 proteins that affect the vascular permeability and impairs the functionality of other significant organs has been identified.
9. 1. Neuroscience

   Subpopulations of neurons in lOFC encode previous and current rewards at time of choice

   David L Hocker et al.
10. 1. Immunology and Inflammation

    Protein kinase Cδ is essential for the IgG response against T cell-independent type 2 antigens and commensal bacteria

    Saori Fukao et al.