A potential drug target for pancreatic cancer

Latest research

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank

   Ardalan Naseri, Degui Zhi, Shaojie Zhang

   ROH-DICE is an efficient method for detecting ROH clusters in biobank data, enabling the study of population history of large cohorts, and providing a new genome-wide association analysis approach for finding disease-causing loci with multi-marker recessive effects.
2. 1. Neuroscience

   Glutamate neurotransmission from leptin receptor cells is required for typical puberty and reproductive function in female mice

   Cristina Sáenz de Miera, Nicole Bellefontaine ... Carol F Elias

   Glutamate neurotransmission from hypothalamic ventral premammillary nucleus is indispensable for leptin action in pubertal development and typical reproduction.
3. 1. Medicine

   An atlas of brain-bone sympathetic neural circuits in mice

   Vitaly Ryu, Anisa Azatovna Gumerova ... Mone Zaidi

   Central SNS outflow sites originating from 87 brain nuclei and sub-nuclei in six brain divisions innervate bone.
4. 1. Neuroscience

   Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments

   MinHyuk Lee, Se Hoon Park ... KyeongJin Kang
5. 1. Neuroscience

   A dynamic generative model can extract interpretable oscillatory components from multichannel neurophysiological recordings

   Proloy Das, Mingjian He, Patrick L Purdon
6. 1. Biochemistry and Chemical Biology

   The TTLL10 polyglycylase is stimulated by tubulin glutamylation and inhibited by polyglycylation

   Steven W Cummings, Yan Li ... Antonina Roll-Mecak
7. 1. Structural Biology and Molecular Biophysics

   Decoupling of the Onset of Anharmonicity between a Protein and Its Surface Water around 200 K

   Lirong Zheng, Bingxin Zhou ... Liang Hong
8. 1. Ecology

   Habitat fragmentation mediates the mechanisms underlying long-term climate-driven thermophilization in birds

   Juan Liu, Morgan W Tingley ... Xingfeng Si
9. 1. Cell Biology

   Vacuolar H⁺-ATPase determines daughter cell fates through asymmetric segregation of the nucleosome remodeling and deacetylase complex

   Zhongyun Xie, Yongping Chai ... Wei Li

   Asymmetric segregation of V-ATPase may cause distinct acidification levels in the two daughter cells, enabling asymmetric epigenetic inheritance that specifies their respective life-versus-death fates.
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals

    Lisa Baumgartner, Jonathan J Ipsaro ... Julius Brennecke

    Genetic and biochemical characterization reveals how a single amino acid change in the chromodomain of the HP1 protein Rhino enables its specific interaction with the guidance factor Kipferl.