Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article

  • Mechanics of oncogenesis

    Integrative mechanobiological approaches provide insight into the biophysics of tissue-specific tumor growth.

    Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
    Research Article

  • Signals for retinal development

    Synchronous waves of activity in the developing retina of postnatal mice potentially involve purinergic signalling triggered by apoptotic retinal ganglia.

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    Reviewed Preprint Updated

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • Hippocampal memory

    Genetic evidence highlights the roles of atypical protein kinase C isoforms in hippocampal late-phase long-term potentiation and long-term memory.

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
    Research Advance

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    A transient hypothalamic CRH signal coordinates social investigation in mice

    Ibukun Akinrinade, Meenakshi Pardasani ... Jaideep S Bains
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Alzheimer disease: The proposed role of tanycytes in the formation of tau tangles and amyloid beta plaques in human brain

    Ruth Fabian-Fine, Abigail G Roman, Adam L Weaver
    Not revised
    Reviewed Preprint v1
    • Inadequate
    1. Microbiology and Infectious Disease

    An innovative tool for non-invasive contact-free pathogen monitoring in animal saliva

    Maristela Martins de Camargo, Aspen Caim Fernandes Gonçalves ... Dawn Zimmerman
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease
    2. Ecology

    Environmental temperature is a strong driver of subspecies competition in the Drosophila microbiome

    Bosco Gracia-Alvira, Stefanie Migotti ... Christian Schlötterer
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Beyond the Focus of Expansion: Retinal curl as a functional signal for heading estimation

    Kontessa I Zorpala, Joan López-Moliner
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Ventromedial striatal dopamine dynamically integrates motivated action and reward proximity

    Eugenia Z Poh, Nicky L Buitelaar ... Ingo Willuhn
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

    Binnu Gangadharan, Daniel L Kober, Luke M Rice
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Five-layer systems analysis of Leishmania stage differentiation reveals an essential role for protein degradation in parasite development

    Pascale Pescher, Thibaut Douché ... Gerald F Späth
    Integrated multi-omics profiling provides evidence for coordinated changes across RNA turnover, translation, phosphorylation, and protein degradation during Leishmania differentiation, generating candidate therapeutic targets for leishmaniasis.
    1. Neuroscience

    Human brain-wide activation of sleep rhythms

    Haiteng Wang, Qihong Zou ... Yunzhe Liu
    Simultaneous EEG–fMRI recordings in 107 human participants link coupled slow oscillations and sleep spindles to thalamic coordination of hippocampal–prefrontal communication during deep sleep.
    1. Neuroscience

    Closed-loop neurofeedback reshapes preparatory brain states to bias subsequent pain processing

    Yinhua Zhang, Shuang Qiu ... Weiwei Peng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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Magazine

    1. Epidemiology and Global Health

    Malaria Prevention: Using mathematical models to optimise mosquito net distribution

    Carlos A Prete Jr
    1. Plant Biology

    Mixotrophy: An updated view of glucose pathways in cyanobacteria

    José Manuel García-Fernández
  3. Mountain gorilla

    Episode 104: July 2026

    1. Cell Biology
    2. Developmental Biology

    Organ Development: Following your heart as it takes shape

    Alexandra Trouilloud, Nicole C Dubois
    1. Cancer Biology

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    1. Neuroscience

    Brain Mapping: Understanding the cellular architecture of Huntington’s disease

    Dorian Pustina
    1. Physics of Living Systems

    Vector Biology: The exquisite mechanics of a tsetse bite

    Katelyn Fealy, Álvaro Acosta-Serrano
  8. See more Magazine articles

Categories

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  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
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