Latest research

1. 1. Cancer Biology

   Arbidol inhibits human esophageal squamous cell carcinoma growth in vitro and in vivo through suppressing ataxia telangiectasia and Rad3-related protein kinase

   Ning Yang, Xuebo Lu ... Kangdong Liu

   Arbidol is a ATR inhibitor to reduce the phosphorylation and activation of MCM2 at Ser108, and innhibits the cell proliferation of ESCC in vitro and in vivo through the DNA replication and cell cycle pathway.
2. 1. Immunology and Inflammation
   2. Medicine

   Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

   Iago de Castro Silva, Anna Bianchi ... Jashodeep Datta

   A neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling axis in the pancreatic tumor microenvironment underlies the association between neutrophil-to-lymphocyte ratio dynamics and pathologic response in patients with pancreatic ductal adenocarcinoma undergoing neoadjuvant therapy.
3. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis

   Lena Maria Muckenfuss, Anabel Carmen Migenda Herranz ... Martin Jinek

   Molecular details of the interactions of human Fip1 with CPSF30 and CstF77 unravel key aspects of mRNA polyadenylation and its regulation.
4. 1. Immunology and Inflammation
   2. Medicine

   Bone marrow adipocytes drive the development of tissue invasive Ly6C^high monocytes during obesity

   Parastoo Boroumand, David C Prescott ... Amira Klip

   Diet-induced obesity in mice led to a duration of diet-dependent bone marrow adipocyte whitening, which drove monocyte expansion and skewing towards a tissue-invasive phenotype, likely contributing to ensuing tissue infiltration that accompanies obesity and diabetes.
5. 1. Developmental Biology
   2. Genetics and Genomics

   Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves

   Melanie MY Chan, Omid Sadeghi-Alavijeh ... Daniel P Gale

   A genome-wide association study using whole-genome sequencing data identifies the first known susceptibility genes for posterior urethral valves, the most common cause of kidney failure in boys, implicating the transcription factor TBX5 and planar cell polarity gene PTK7.
6. 1. Cell Biology
   2. Neuroscience

   Keratinocyte PIEZO1 modulates cutaneous mechanosensation

   Alexander R Mikesell, Olena Isaeva ... Cheryl L Stucky

   Epidermal PIEZO1 is a key keratinocyte mechanotransducer which mediates normal behavioral and sensory neuron responses to cutaneous mechanical stimulation.
7. 1. Developmental Biology
   2. Genetics and Genomics

   Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm

   Elizabeth M Sefton, Mirialys Gallardo ... Gabrielle Kardon

   HGF derived from fibroblasts is critical for complete muscularization of the mammalian diaphragm, and loss-of-function experiments reveal that partial muscularization of the diaphragm is not sufficient to cause congenital diaphragmatic hernias.
8. 1. Microbiology and Infectious Disease

   c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis

   Nadine Vollmuth, Lisa Schlicker ... Thomas Rudel

   The central immune modulator interferon-gamma downregulates the proto-oncogene c-Myc to shut down host cell metabolism and interfere with infection of epithelial cells by obligate intracellular pathogenic Chlamydia trachomatis.
9. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor

   Antigoni Gogolou, Celine Souilhol ... Anestis Tsakiridis
10. 1. Cell Biology
    2. Genetics and Genomics

    Differential requirements for mitochondrial electron transport chain components in the adult murine liver

    Nicholas P Lesner, Xun Wang ... Prashant Mishra