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Latest research

    1. Neuroscience

    Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice

    Chang-Rui Chen et al.
    The paraventricular nucleus of the hypothalamus is essential for physiologic arousal and the pathogenesis underlying hypersomnolence disorder.
    1. Neuroscience

    Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools

    Remi Ronzano et al.
    Populations of spinal cord neurons innervate motoneurons controlling local and distant synergist and antagonist muscles.
    1. Genetics and Genomics

    Relating multivariate shapes to genescapes using phenotype-biological process associations for craniofacial shape

    Jose D Aponte et al.
    Multivariate genotype-phenotype mapping enables quantification of pathway and process-level effects on complex phenotypes and predicts phenotypic effects of novel mutations.
    1. Plant Biology

    Functional diversification gave rise to allelic specialization in a rice NLR immune receptor pair

    Juan Carlos De la Concepcion et al.
    Biochemical and in planta studies reveal how a rice immune receptor pair has coevolved to deliver immune responses, an important step towards understanding and engineering bespoke resistance to crop pathogens that threaten food security.
    1. Biochemistry and Chemical Biology

    Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors

    Xiaozheng Xu et al.
    A molecular interpretation is provided for why some inhibitory immunoreceptors prefer to recruit SHP1 but others prefer SHP2.
    1. Neuroscience

    Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics

    Takamitsu Watanabe
    Prefrontal causal roles in bistable perception are dynamically changing and determined by the brain state to which the whole-brain activity pattern belongs.
    1. Evolutionary Biology

    Ovipositor and mouthparts in a fossil insect support a novel ecological role for early orthopterans in 300 million years old forests

    Lu Chen et al.
    Hundreds of fossil remains shed new light on the evolution of grasshoppers, gryllids, and katydids and their ecological role 300 million years ago.
    1. Computational and Systems Biology
    2. Neuroscience

    Daily electrical activity in the master circadian clock of a diurnal mammal

    Beatriz Bano-Otalora et al.
    Circadian control of neuronal excitability in the master circadian clock of a diurnal mammal as revealed by whole-cell recording and mathematical modeling.
    1. Cancer Biology

    Glutamine deprivation triggers NAGK-dependent hexosamine salvage

    Sydney Campbell et al.
    Hexosamine salvage through the enzyme N-acetylglucosamine kinase is stimulated in nutrient-limited conditions and supports pancreatic tumor growth.