Molecular architecture of the IFT-A complex

Latest research

1. 1. Neuroscience

   Binary and analog variation of synapses between cortical pyramidal neurons

   Sven Dorkenwald, Nicholas L Turner ... H Sebastian Seung

   Sizes of synapses between layer 2/3 pyramidal cells in mouse primary visual cortex are well modeled by the sum of a binary variable and an analog variable drawn from a log-normal distribution.
2. 1. Epidemiology and Global Health
   2. Evolutionary Biology

   Taxonium, a web-based tool for exploring large phylogenetic trees

   Theo Sanderson

   A new tool allows researchers to dive into phylogenetic trees containing millions of nodes using just their web browser.
3. 1. Microbiology and Infectious Disease

   Glutamine synthetase mRNA releases sRNA from its 3´UTRto regulate carbon/nitrogen metabolic balance in Enterobacteriaceae

   Masatoshi Miyakoshi, Teppei Morita ... Kan Tanaka
4. 1. Developmental Biology
   2. Genetics and Genomics

   Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models

   Suhee Chang, Diana Fulmer ... Marisa S Bartolomei

   Precise dosage of the imprinted H19 and Igf2 genes is critical for normal embryonic development, especially related to the cardiac-placental axis.
5. 1. Structural Biology and Molecular Biophysics

   Sublytic gasdermin-D pores captured in atomistic molecular simulations

   Stefan L Schaefer, Gerhard Hummer

   Molecular dynamics simulations reveal the formation of membrane pores by gasdermin-D, the ultimate effector of pyroptotic cell death in inflammation and infection.
6. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Chronic Ca²⁺ imaging of cortical neurons with long-term expression of GCaMP-X

   Jinli Geng, Yingjun Tang ... Xiaodong Liu

   Focusing on calcium oscillations in relation to neuronal morphology both in vitro and in vivo, rationally designed GCaMP-X provides a simple solution to neuronal toxicity of conventional GCaMP in imaging applications involving prolonged and/or strong expression of calcium probes.
7. 1. Neuroscience

   Dorsal striatum coding for the timely execution of action sequences

   Maria Cecilia Martinez, Camila Lidia Zold ... Mariano Andrés Belluscio

   In adolescent rats, whose actions are more impulsive, neuronal striatal activity that precedes self-initiated action sequences has a steeper modulation by waiting time compared to the modulation found in adults.
8. 1. Immunology and Inflammation

   Cell-intrinsic ceramides determine T cell function during melanoma progression

   Matthias Hose, Anne Günther ... Wiebke Hansen

   Cell-intrinsic ceramide concentrations are involved in T cell differentiation and function.
9. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion

   Nil Z Gurel, Koustubh B Sudarshan ... Olujimi A Ajijola
10. 1. Cancer Biology
    2. Medicine

    Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review

    Huan-Huan Chen, Tie-Ning Zhang ... Tao Zhang

    Non-coding RNAs appear to be good candidates as biomarkers for predicting treatment response and therapeutics for sarcoma, their differential expression across tissues complicates their application.