• lncRNAs and the heart

    A long noncoding RNA called CHARME promotes the maturation of cardiomyocytes in the developing heart.

    Valeria Taliani, Giulia Buonaiuto ... Monica Ballarino
    Research Article Updated
  • The origin of hagfish slime

    Microscopy studies and transcriptome analyses have shown that the slime glands of hagfish evolved from cells and genes expressed in the skin.

    Yu Zeng, David C Plachetzki ... Douglas Fudge
    Research Article
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    All papers reviewed by eLife are published as Reviewed Preprints, which combine the advantages of preprints with the scrutiny offered by peer review

    Inside eLife

Latest research

    1. Microbiology and Infectious Disease

    Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment

    Abdirahman I Abdi, Fiona Achcar ... Matthias Marti
    We investigate how parasites adapt to environmental changes in the context of changing transmission patterns, for example by increasing investment in transmission stages at low endemicity such as elimination settings.
    1. Neuroscience

    Distinct roles of forward and backward alpha-band waves in spatial visual attention

    Andrea Alamia, Lucie Terral ... Rufin VanRullen
    Covert visual attention modulates alpha-band traveling waves propagating from frontal to occipital regions in both hemispheres, yet it modulates waves propagating in the opposite direction (occipital to frontal) only in the presence of visual stimulation.
    1. Neuroscience

    Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

    Kieran A. Boyle, Erika Polgár ... Andrew J. Todd
    1. Cell Biology

    Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

    Danielle B Buglak, Pauline Bougaran ... Victoria L Bautch
    The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function.
    1. Stem Cells and Regenerative Medicine
    2. Developmental Biology

    Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids

    Jaydeep Sidhaye, Philipp Trepte ... Jürgen A Knoblich
    RNA-protein multiome approach helps to discover that the posttranscriptional regulation of the translational machinery is crucial for the fidelity of cortical development.
    1. Structural Biology and Molecular Biophysics

    Structural insight into the stabilization of microtubules by taxanes

    Andrea E Prota, Daniel Lucena-Agell ... J Fernando Díaz
    Crystal structures of taxane-tubulin complexes allow the understanding of the interaction of paclitaxel (Taxol) with its cellular target in atomic detail and assess the structural determinants for binding.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly

    Hirohide Takahashi, Toshiki Yamada ... Erkan Karakas
    The cryo-electron microscopy structures of an LRRC8C chimera with native channel properties reveal the diverse oligomeric assembly and suggest that lipids may play a role in gating in volume-regulated anion channels.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics

    Sean M Braet, Theresa SC Buckley ... Ganesh S Anand
    Structural mass spectrometry reveals conformational changes in emerging SARS-CoV-2 spike protein variants that correlate with increased viral fitness.
    1. Neuroscience

    Inhibition drives habituation of a larval zebrafish visual response

    Laurie-Anne Lamiré, Martin Haesemeyer ... Owen Randlett