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Latest research

1. 1. Cancer Biology
   2. Cell Biology

   ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

   Kimberly J Morgan, Karen Doggett ... Joan K Heath

   ELYS, a multifunctional protein with critical roles in the cell cycle, is essential for the vigorous proliferation and survival of difficult-to-treat cancers carrying mutations in the KRAS oncogene, making it a compelling target for novel drug treatments.
2. 1. Cancer Biology
   2. Microbiology and Infectious Disease

   Beta human papillomavirus 8E6 promotes alternative end joining

   Changkun Hu, Taylor Bugbee ... Nicholas Wallace

   Human papillomavirus type 8 E6 promotes alternative end joining by compromising non-homologous end joining and homologous recombination.
3. 1. Microbiology and Infectious Disease

   Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system

   Fabrice Jean-Pierre, Thomas H Hampton ... George A O'Toole

   A cystic fibrosis (CF) lung microbiome-informed in vitro polymicrobial system allows for a mechanistic understanding of community-specific tolerance of Pseudomonas aeruginosa to a front-line CF antimicrobial.
4. 1. Neuroscience

   A striatal circuit balances learned fear in the presence and absence of sensory cues

   Michael Kintscher, Olexiy Kochubey, Ralf Schneggenburger

   Direct- and indirect pathway neurons of the posterior striatum display divergent in vivo and ex vivo plasticity after fear learning, and differentially modulate defensive behaviors displayed in the presence, and absence of threat-predicting sensory cues.
5. 1. Cell Biology
   2. Immunology and Inflammation

   Spatially resolved transcriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10

   Ana J Caetano, Yushi Redhead ... Paul T Sharpe

   Integrated single-cell and spatial genomics provides the first molecular map of the human oral mucosa and reveals a novel pro-inflammatory fibroblast involved in disease progression.
6. 1. Ecology
   2. Microbiology and Infectious Disease

   Host-microbiome metabolism of a plant toxin in bees

   Erick VS Motta, Alejandra Gage ... Nancy Moran

   The bee gut microbiota contributes to the metabolism of the cyanogenic glycoside amygdalin.
7. 1. Cell Biology

   Competition between myosin II and β_H-Spectrin regulates cytoskeletal tension

   Consuelo Ibar, Krishna Chinthalapudi ... Kenneth D. Irvine
8. 1. Genetics and Genomics
   2. Neuroscience

   The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

   Lukas M. Weber, Heena R. Divecha ... Stephanie C. Hicks
9. 1. Epidemiology and Global Health

   The impact of the COVID-19 pandemic on Italian population-based cancer screening activities and test coverage: results from national cross-sectional repeated surveys in 2020

   Paolo Giorgi Rossi, Giuliano Carrozzi ... Paola Mantellini
10. 1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cells

    Serkan Sayin, Brittany Rosener ... Amir Mitchell