Highlights

  • Seeing movement

    Inhibitory feedback from GABAergic interneurons C2 and C3 is tied to neural computation of moving visual stimuli in Drosophila.

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Research Article
  • Testing the blood-brain barrier

    pdgfrb knockout zebrafish, which lack mural cells in their neurovasculature, retain restrictive permeability of the blood-brain barrier during developmental stages.

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    Research Article
  • Making of the microenvironment

    Single-cell sequencing and multi-omics approaches reveal the influence of BRCA1/2 mutations on the tumor microenvironment in lung adenocarcinoma.

    Gaoming Liao, Xinbin Yang ... Gang Xu
    Research Article
  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial
  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
  • How to respond to peer reviewers

    Responding to peer reviews is a crucial part of publishing, but early-career researchers are rarely taught about it.

    Eric Kalkhoven, Manon Kluijtmans
    Feature Article

Latest research

    1. Neuroscience

    Theta-Beta Ratio in Attention Deficit Hyperactivity Disorder: A Multiverse Analysis

    Dawid Strzelczyk, Andrea Vetsch, Nicolas Langer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Exceptional
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Atomistic simulations reveal sub-µs contact dynamics in MUT-16 condensates

    Kumar Gaurav, Lucia Baltz ... Lukas S Stelzl
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    The view tolerance of human identity recognition depends on horizontal face information

    Alexia Roux-Sibilon, Hélène Dumont ... Valérie Goffaux
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Ecology

    Scanning and active sampling behaviours emerge from conserved insect neural circuits

    Cody A Freas, Antoine Wystrach
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology

    The chromokinesin Kid (KIF22) forms a homodimer, moves processively along microtubules and transports double-stranded DNA

    Shinsuke Niwa, Natsuki Furusaki ... Kyoko Chiba
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Dendritic delay lines shape the computation of sound location in neurons of the gerbil medial superior olive

    Jared Casarez, Rebecca I Voglewede ... Nace L Golding
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Long Wake/Short Sleep Bouts and Hyperactivity with Advanced Age in a Mouse Model of Early Onset Alzheimer’s Disease

    Ryan K Tisdale, Yu Sun ... Thomas S Kilduff
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Conformational Variability of HIV-1 Env Trimer and Viral Vulnerability

    Yiwei Cao, Wonpil Im
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    The insulin / IGF axis is critically important for controlling gene transcription in the podocyte

    Jennifer A Hurcombe, Lusyan Dayalan ... Richard JM Coward
    Revised
    Reviewed Preprint v4
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

    Qian Lyu, Qingchao Li ... Huijie Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid