Secrets of metamorphosis

Latest research

1. 1. Medicine

   Noninvasive ultrasound targeted modulation of calcium influx in splenic immunocytes potentiates antineoplastic immunity attenuating hepatocellular carcinoma proliferation

   Wei Dong, Guihu Wang ... Zongfang Li
2. 1. Genetics and Genomics
   2. Evolutionary Biology

   Refining the resolution of the yeast genotype-phenotype map using single-cell RNA-sequencing

   Arnaud N’Guessan, Wen Yuan Tong ... Alex N Nguyen Ba
3. 1. Immunology and Inflammation

   Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

   Wesley H Godfrey, Judy J Lee ... Michael D Kornberg
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes

   Janelle JY Chuah, Madalena R Daugherty, David M Smith
5. 1. Microbiology and Infectious Disease
   2. Cancer Biology

   The lnc-FANCI-2 intrinsically restricts RAS signaling in HPV16-infected cervical cancer

   Haibin Liu, Lulu Yu ... Zhi-Ming Zheng
6. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids

   David Saeb, Emma E Lietzke ... Kayla G Sprenger
7. 1. Immunology and Inflammation

   Xcr1⁺ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

   Tianhan Li, Liaoxun Lu ... Lichen Zhang
8. 1. Neuroscience

   Odors drive feeding through gustatory receptor neurons in Drosophila

   Hong-ping Wei, Thomas Ka Chung Lam, Hokto Kazama
9. 1. Cell Biology
   2. Medicine

   The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

   Fan Zhang, Yuan Wang ... Xianpeng Ge

   CHMP5 is crucial in preventing skeletal progenitor cell senescence and abnormal bone formation, and senolytic drugs represent potential therapeutic medicine for musculoskeletal abnormalities associated with a dysfunctional endolysosomal pathway.
10. 1. Medicine
    2. Stem Cells and Regenerative Medicine

    Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

    M Reza Bahranifard, Jessica Chan ... C Ross Ethier

    Magnetically steered mesenchymal stem cells significantly lowered intraocular pressure for 9 months in mice, motivating the translation of this technology for the treatment of glaucoma.