Highlights

  • Microglia on the move

    Microglia adopt fundamentally different strategies for surveilling the health of neurons during chronic neurodegeneration.

    Sunitha Subhramanian, Olga Bocharova ... Ilia V Baskakov
    Research Article

  • Shaping male behaviours in fish

    Estrogens produced in the brain increase neural sensitivity to testicular androgens, and thus elicit male-typical behaviors, in the Japanese rice fish.

    Yuji Nishiike, Shizuku Maki ... Kataaki Okubo
    Research Article

  • X-rays impact gene expression

    Exposing the wing discs of Drosophila to X-rays leads to heterogenous changes in gene expression that are related to cell-cycle status and cell location.

    Joyner Cruz, Willam Y Sun ... Iswar K Hariharan
    Reviewed Preprint Updated

  • Research culture

    The Researcher Development Concordat has led to improvements in research culture in the UK, but there is still more to do.

    Robert AR Drake, Laura A Gray ... Joan Chang
    Feature Article

  • Where theory meets biology

    eLife author Veronika Koren, a computational neuroscientist, answers questions about her work on efficient coding.

    Inside eLife

  • What is a Reviewed Preprint?

    Reviewed Preprints provide benefits to authors and to the wider scientific community.

    Inside eLife
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Developmental Biology

    Human spinal cord organoids reveal cell intercalation as a conserved mechanism for secondary neurulation

    José Blanco-Ameijeiras, Yara El Majzoub ... Elisa Martí
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Cancer Biology

    RAB14-dependent tubulovesicular recycling directs MET to invadopodia, promoting TNBC cell invasion

    Amrita Khamari, Atreyee Guria ... Sunando Datta
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation

    Ioakeim Ampartzidis, Elliott M Thompson ... Gabriel L Galea
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Purified Zymogens Reveal Mechanisms of Snake Venom Metalloproteinase Auto-Activation

    Sophie Hall, Iara Aimê Cardoso ... Christiane Schaffitzel
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Structural Biology and Molecular Biophysics

    Structure of the human CTF18–RFC clamp loader bound to PCNA

    Giuseppina R Briola, Muhammad Tehseen ... Alfredo De Biasio
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    ZFT is the major iron and zinc transporter in Toxoplasma gondii

    Dana Aghabi, Cecilia Gallego Rubio ... Clare R Harding
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy

    Liudmyla Arifova, Brian S MacTavish ... Douglas J Kojetin
    Covalent PPARγ inhibitors that better stabilize a repressive conformation are more effective inhibitors, but structural plasticity still allows ligand cobinding by enabling a shift back to an active conformation.
    1. Computational and Systems Biology
    2. Developmental Biology

    Anti-resonance in developmental signaling regulates cell fate decisions

    Samuel J Rosen, Olivier Witteveen ... Maxwell Z Wilson
    Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is capable of redirecting developmental fate outcomes, including germ-layer specification.
    1. Structural Biology and Molecular Biophysics

    Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

    Shuang Chen, Andrew R Mack ... Shozeb Haider
    Clinically relevant Ω-loop mutations in PDC-3 reshape active-site dynamics to enhance β-lactamase activity, providing mechanistic insights that can guide the rational design of inhibitors.
    1. Immunology and Inflammation

    Western lifestyle linked to maladaptive trained immunity

    Aurelia Josephine Merbecks, Christabel Mennicken ... Eicke Latz
    Trained immunity enhances innate immune responses, yet a Western lifestyle may lead to maladaptive trained immunity and drive non-communicable diseases.
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Magazine

    1. Developmental Biology

    Limb Patterning: The cellular logic of limb regeneration

    Matthew Cherubino, Catherine D McCusker
    1. Neuroscience

    Aging: Linking neuron-glia interactions and longevity

    Michael Pokrass, Nan Hao

  3. Research Culture: Going beyond compliance to build on the Researcher Development Concordat

    Robert AR Drake, Laura A Gray ... Joan Chang
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt
    1. Cancer Biology
    2. Cell Biology

    Chemotherapy: Lipid balance and chemoresistance in cancer cells

    Kaori Kanemaru, Yoshikazu Nakamura
    1. Genetics and Genomics
    2. Physics of Living Systems

    Raman Spectroscopy: Probing the proteome

    Wei-Hsiang Lin, Chia-Liang Cheng
    1. Genetics and Genomics
    2. Neuroscience

    Opioid Use Disorder: Identifying new targets in the fight against opioids

    Fernanda Laezza
  8. See more Magazine articles

Categories

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  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
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  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
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  14. Neuroscience
  15. Physics of Living Systems
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  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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