eLife works to improve research communication through open science and open technology innovation

Latest research

    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism

    Anirban Roy et al.
    The IRE1/XBP1 signaling in myofibers is essential for robust skeletal muscle regeneration in response to injury.
    1. Microbiology and Infectious Disease

    A nanocompartment system contributes to defense against oxidative stress in Mycobacterium tuberculosis

    Katie A Lien et al.
    A peroxidase-containing nanocompartment in the bacterial pathogen Mycobacterium tuberculosis protects against oxidative stress and antibiotic treatment in the host.
    1. Neuroscience

    Motor memories of object dynamics are categorically organized

    Evan Cesanek et al.
    The motor-relevant properties of the myriad objects with which we interact on a daily basis are encoded in memory using categorical representations, or 'object families'.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

    Aixin Song et al.
    Through interactions with both ubiquitin units that emanate from a branch point in polyubiquitin, UCH37 recognizes and hydrolyzes branched chains to promote proteasome-mediated degradation upon proteolytic stresses.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel

    Cathrine Bergh et al.
    Computational models of gating processes in an ion channel show how stability shifts upon ligand-binding and mutations are reproduced, which highlights mechanistic details and proposes a new role for symmetry in gating.
    1. Cell Biology
    2. Neuroscience

    Ca2+/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation

    Domenica Ippolito et al.
    Ca2+-dependent nuclear entry of Ca2+/calmodulin-dependent protein kinase-1 in sensory neurons, taking place with a relatively slow kinetics, contributes to couple long-lasting sensory stimulations with signaling in the nucleus over a timescale relevant for sensory history-dependent plasticity.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    A recombinant protein containing influenza viral conserved epitopes and superantigen induces broad-spectrum protection

    Yansheng Li et al.
    By fusing influenza viral conserved epitopes and a superantigen fragment, we constructed a recombinant protein that might be a candidate universal broad-spectrum vaccine for the prevention and treatment of multiple influenza viruses.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    High rates of evolution preceded shifts to sex-biased gene expression in Leucadendron, the most sexually dimorphic angiosperms

    Mathias Scharmann et al.
    In the dioecious plant genus Leucadendron, shifts to sex-biased gene expression occurred predominantly in genes with ancestrally high rates of expression evolution, and were not correlated with morphology.
    1. Immunology and Inflammation

    The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

    Rafael Bayarri-Olmos et al.
    Functional characterization of the alpha/B1.1.7 SARS-CoV-2 variant revealed an eightfold affinity increase of the N501Y RBD to human ACE-2 and that even a low inoculation dose of the alpha variant induces severe disease and fast progression in transgenic hACE2 mice.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers

    Mark Ferris et al.
    Healthcare workers working on COVID-19 wards experience a 31-fold increased risk of infection with SARS-CoV-2 compared to colleagues on non-COVID-19 wards whilst wearing fluid-resistant surgical masks, and FFP3 respirators provide up to 100% protection against infection.