Funders embrace reviewed preprints

Latest research

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Evaluation of in silico predictors on short nucleotide variants in HBA1, HBA2, and HBB associated with haemoglobinopathies

   Stella Tamana, Maria Xenophontos ... Petros Kountouris

   The calibration of decision thresholds will provide evidence for the optimal use of in silico predictors for the standardised classification of globin gene variants under the American College of Medical Genetics and Genomics/Association for Molecular Pathology framework.
2. 1. Neuroscience

   Oscillations support short latency co-firing of neurons during human episodic memory formation

   Frédéric Roux, George Parish ... Simon Hanslmayr

   Synchronization of neural firing in the medial temporal lobe at fast, but not slow, theta and gamma oscillations correlates with shorter latencies of co-firing and successful memory formation.
3. 1. Microbiology and Infectious Disease

   Glutamine synthetase mRNA releases sRNA from its 3′UTR to regulate carbon/nitrogen metabolic balance in Enterobacteriaceae

   Masatoshi Miyakoshi, Teppei Morita ... Kan Tanaka

   Under nitrogen limitation, Salmonella and Escherichia coli express a messenger RNA to translate glutamine synthetase, and concomitantly the messenger RNA produces a small RNA from its 3′ end to inhibit the translation of 2-oxoglutarate dehydrogenase of the TCA cycle.
4. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast

   Radhika A Varier, Theodora Sideri ... Folkert J van Werven

   N6-methyladenosine (m6A) reader Pho92 is directed by Paf1C to meiotic mRNAs in an m6A-dependent and independent manner and promotes CCR4-NOT-mediated mRNA decay of m6A modified transcripts contingent on translation.
5. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor

   Jie Li, Jiayi Wu ... Eunhee Choi

   A critical role of aCT in the distinct activation mechanism of insulin receptor and insulin-like growth factor 1 receptor.
6. 1. Neuroscience

   Human hippocampal responses to network intracranial stimulation vary with theta phase

   Sarah M Lurie, James E Kragel ... Joel L Voss

   Human hippocampal connectivity to network afferents varies continuously with the phase of the local theta oscillation, confirming a putative mechanism by which neural oscillations modulate human hippocampal function.
7. 1. Cancer Biology
   2. Genetics and Genomics

   Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors

   Minsu Kang, Hee Young Na ... Jong Seok Lee
8. 1. Neuroscience

   Scratch-AID: a deep-learning based system for automatic detection of mouse scratching behavior with high accuracy

   Huasheng Yu, Jingwei Xiong ... Wenqin Luo
9. 1. Immunology and Inflammation

   Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

   Shojiro Haji, Taiki Ito ... Sho Yamasaki
10. 1. Neuroscience

    Emotional learning retroactively promotes memory integration through rapid neural reactivation and reorganization

    Yannan Zhu, Yimeng Zeng ... Shaozheng Qin