Latest research

1. 1. Cancer Biology
   2. Neuroscience

   Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice

   Susu Pan et al.

   Assessments using chemogenetic and pharmacological approaches reveal that modulation of the activities of oxytocin neurons in the hypothalamus of the central nervous system could inhibit colorectal cancer progression in mice.
2. 1. Ecology

   Little evidence that Eurasian jays protect their caches by responding to cues about a conspecific’s desire and visual perspective

   Piero Amodio et al.

   Across five experiments, Eurasian jays’ caching behaviour provides little evidence of the ability to integrate cues about a potential pilferer’s visual perspective and desire and, challenging previous findings, to respond to either of the two social cues independently.
3. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development

   Amy Reilein et al.

   Somatic stem and niche cells in the Drosophila ovary develop from common precursors through regulated proliferative expansion, followed by acquisition of position-specific behaviors, rather than through rigid early specification events.
4. 1. Neuroscience

   A state space modeling approach to real-time phase estimation

   Anirudh Wodeyar et al.

   A statistically principled approach developed to estimate phase of rhythmic signals in real-time shows robustness to multiple sources of error and also provides confidence criteria.
5. 1. Structural Biology and Molecular Biophysics

   Transcription initiation at a consensus bacterial promoter proceeds via a ‘bind-unwind-load-and-lock’ mechanism

   Abhishek Mazumder et al.

   Single-molecule fluorescence experiments reveal transcription initiation proceeds via a 'bind-unwind-load-and-lock' mechanism where promoter DNA unwinds outside the RNA polymerase (RNAP) cleft, the unwound template-DNA loads into the cleft, and RNAP 'locks' the template-DNA by closing the RNAP clamp module.
6. 1. Microbiology and Infectious Disease

   Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients

   João L Silva-Filho et al.

   Data exploring host and parasite signatures in the peripheral blood indicate that total parasite biomass is a better predictor of P. vivax-induced host responses and pathogenesis than peripheral parasitemia.
7. 1. Evolutionary Biology
   2. Neuroscience

   Molecular reconstruction of recurrent evolutionary switching in olfactory receptor specificity

   Lucia L Prieto-Godino et al.
8. 1. Physics of Living Systems

   Physical observables to determine the nature of membrane-less cellular sub-compartments

   Mathias L Heltberg et al.
9. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Short-chain fatty acids activate acetyltransferase p300

   Sydney P Thomas, John M Denu
10. 1. Cell Biology
    2. Immunology and Inflammation

    Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

    Jenny K Gustafsson et al.