Highlights

  • ITP signaling and homeostasis

    The ion transport peptide (ITP) signaling system relies on a guanylate cyclase receptor to maintain homeostasis in Drosophila.

    Jayati Gera, Marishia Agard ... Meet Zandawala
    Research Article

  • Focus Issue: Trained Immunity

    The articles in this focus issue discuss progress towards a better understanding of memory in the innate immune system, and efforts to develop new vaccines and therapeutics based on “trained immunity”.

    Collection

  • Phosphate buffering

    Lysosome-related vacuoles control the metabolism of inorganic polyphosphates to stabilize the concentration of phosphate in the cytosol.

    Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
    Research Article

  • How we understand each other

    eLife author Joe Barnby answers questions about a study that explored how humans navigate social interactions.

    Inside eLife

  • No change for astroctyes

    Genetically removing the RNA-binding protein PTBP1 from astrocytes does not convert them into neurons, contrary to previous claims.

    Min Zhang, Naoto Kubota ... Sika Zheng
    Research Article

  • Drug-resistant sleeping sickness

    Mutations in a water channel called TbAQP2 make the parasite that causes sleeping sickness resistant to drugs. Image: Jessica Eggers (CC BY 4.0).

    Modestas Matusevicius, Robin A Corey ... Simone N Weyand
    Reviewed Preprint Updated
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Microbiology and Infectious Disease

    Peptidoglycan recycling is critical for cell division, cell wall integrity and β-lactam resistance in Caulobacter crescentus

    Pia Richter, Anna Merz ... Martin Thanbichler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Neuroscience

    Dynamic regulation of mRNA acetylation at synapses by spatial memory in mouse hippocampus

    Hai-Qian Zhou, Zhen Zhu ... Dong-Min Yin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest

    Tim Casey-Clyde, S John Liu ... David R Raleigh
    Eed, a core subunit of Polycomb repressive complex 2, is required for craniofacial osteoblast differentiation and mesenchymal proliferation after induction of the neural crest.
    1. Computational and Systems Biology
    2. Developmental Biology

    MorphoNet 2.0: An innovative approach for qualitative assessment and segmentation curation of large-scale 3D time-lapse imaging datasets

    Benjamin Gallean, Tao Laurent ... Emmanuel Faure
    A collaborative open-source platform enabling interactive 3D visualization, quantitative evaluation, and expert curation of complex biological morphologies to enhance the quality and reproducibility of large-scale imaging studies.
    1. Neuroscience

    TRPV3 channel activity helps cortical neurons stay active during fever

    Yiming Shen, Richárd Fiáth ... Michelle W Antoine
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Distinct brain mechanisms support trust violations, belief integration, and bias in human-AI teams

    Luisa Roeder, Pamela Hoyte ... Johan N van der Meer
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Evolutionary Biology

    Pre-Cambrian origin of envelope-carrying retrotransposons in metazoans

    Shashank Chary, Rippei Hayashi
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Neural coding of multiple motion speeds in visual cortical area MT

    Xin Huang, Bikalpa Ghimire ... Steven Wiesner
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Compelling
    1. Microbiology and Infectious Disease

    Bivalent mRNA booster encoding virus-like particles elicits potent polyclass RBD antibodies in pre-vaccinated mice

    Chengcheng Fan, Alexander A Cohen ... Magnus AG Hoffmann
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Individual differences in tail risk sensitive exploration using Bayes-adaptive Markov decision processes

    Tingke Shen, Peter Dayan
    A normative computational model of individual differences in mouse exploration driven by reward and threat uncertainty as well as risk sensitivity when faced with a novel object in an open field.
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Magazine

    1. Neuroscience

    Neuronal Activity: Keeping track of moving targets

    Renata Batista-Brito, Geoffrey Terral

  2. Research Culture: The SAFE Labs Handbook as a tool for improving lab culture

    Erika Donà, James M Gahan ... Philip Coen
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Genetics and Genomics

    Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

    Lesley T MacNeil
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Focus Issue: Evolving our understanding of trained immunity

    Eva Kaufmann, Yahya Sohrabi ... Jos WM van der Meer
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacteriology: How Shigella tackles host defences

    Yizhou Huang, Teresa LM Thurston
  8. See more Magazine articles

Categories

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  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
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  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
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  18. Structural Biology and Molecular Biophysics
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