Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article
  • Pikas power yak pastures

    Plateau pikas play a role in enhancing weight gains in yaks, by suppressing toxic plants and improving the availability and quality of palatable forage.

    Zhiwei Zhong, Bingbo Ni ... Zhibin Zhang
    Reviewed Preprint Updated
  • Re-evolving traits

    Hybridization chain reaction and confocal imaging reveal latent ocelli gene regulatory network expression in ant workers, with a role in partial re-evolution of caste-specific traits.

    Angelly Vasquez-Correa, Johanna Arnet ... Ehab Abouheif
    Research Article
  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial
  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife
  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article

Latest research

    1. Cell Biology

    Xkr regulates phosphatidylserine transport via ER-PM contact sites to promote apoptotic cell clearance

    Qian Zheng, Xinyu Ma ... Hui Xiao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    MARBL: A Live-Cell Method for Profiling Bioenergetic Heterogeneity by Noncanonical Methionine Labeling of the Cell Surface Proteome

    Lillian R Delacruz, Ming Ye ... Alison E Ringel
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Neuroscience

    Role of GABA and NMDA receptors in shaping cortical timescales and large-scale network dynamics

    Ana Antonia Dias Maile, Oliver Kohl ... Gerhard Jocham
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Dual pathway architecture in songbirds enables robust sensorimotor learning

    Remya Sankar, Atharv Suryawanshi ... Arthur Leblois
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience
    2. Physics of Living Systems

    A multi-muscular, redundant strategy for free-flight roll stability

    B Kemper Ludlow, Serene Dhawan ... Itai Cohen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cell Biology

    Functional High Throughput Drug Screening Reveals Cyproheptadine as a Novel Treatment for LMNA-related Cardiomyopathy

    Hananeh Fonoudi, Ali Negahi Shirazi ... Paul W Burridge
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    In vivo and in silico alpha-synuclein propagation dynamics: The role of genotype, epicentre, and connectivity

    Stephanie Tullo, Janice SH Park ... M Mallar Chakravarty
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Non-decision time: the elephant in the executive control room

    Heather Statham, Phil Schmid ... Aline Bompas
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Neuroscience

    Synaptic vesicle undocking induces low frequency depression

    Melissa Silva, Federico F Trigo ... Alain Marty
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing