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Latest research

    1. Structural Biology and Molecular Biophysics

    Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

    Maicon Landim-Vieira et al.
    Analytical techniques and computational models reveal novel post-translational modifications on β-myosin heavy chain in the human hearts and highlight their potential as therapeutic targets.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Epistatic selection on a selfish Segregation Distorter supergene – drive, recombination, and genetic load

    Beatriz Navarro-Dominguez et al.
    African haplotypes of a meiotic drive supergene in Drosophila melanogaster called Segregation Distorter show signs of a recent selective sweep, reduced recombination, and increased genetic load.
    1. Neuroscience

    Human visual gamma for color stimuli

    Benjamin J Stauch et al.
    Colored surfaces induce gamma oscillations in human early visual cortex that are equally strong for red and green colors when L-M cone contrast is controlled for.
    1. Stem Cells and Regenerative Medicine

    Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model

    Felicia Reinitz et al.
    A neural precursor cell defect precedes widespread inflammation, amyloid plaque pathology, and cognitive deficit in Alzheimer's disease, which can be reversed by inhibiting USP16.
    1. Cell Biology

    C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

    Saskia-Larissa Jauch-Speer et al.
    A genome-wide CRISPR/Cas9 knockout screening approach identified C/EBPδ as transcriptional regulator of the alarmins S100A8 and S100A9 during differentiation of monocytes and inflammatory processes in vivo.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain

    Atefeh Rafiei et al.
    Doublecortin activates its C-terminal domain when its N-terminal domain engages the microtubule lattice, leading to self-associations that explain the stabilizing effect of Doublecortin in neuronal migration.
    1. Chromosomes and Gene Expression

    DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells

    Faith C Fowler et al.
    Molecular analyses and unbiased CRISPR screens reveal that extensive end resection occurs in quiescent cells after inducing DNA double strand breaks, in a manner dependent on DNA-PK.
    1. Structural Biology and Molecular Biophysics

    Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane

    Siyoung Kim et al.
    The functions of seipin in triacylglycerol nucleation and lipid droplet maturation are studied with all-atom and coarse-grained simulations along with cell experiments, providing a novel model for lipid droplet formation.
    1. Ecology
    2. Evolutionary Biology

    Parasite defensive limb movements enhance acoustic signal attraction in male little torrent frogs

    Longhui Zhao et al.
    Multimodal signals may evolve from unimodal one via co-option of primary signal components and associated cues that serve as by-products.