Highlights

Latest research

    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania

    Gabriel H Negreira, Pieter Monsieurs ... Malgorzata A Domagalska
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport

    Masataka Suzuki, Kenichiro Adachi ... Jumpei Sasabe
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Out-of-balance growth enables cost-free synthesis of the flagellum and other proteins in a single bacterium

    Mayra Patricia Garcia Alcala, Josiah C Kratz, Philippe Cluzel
    Surprisingly, monitoring single bacteria expressing constitutive or flagellar genes reveals faster growth, a benefit driven by inherited, cost-free growth factors, whereas bulk measurements show an expected net fitness cost.
    1. Ecology
    2. Genetics and Genomics

    Plasticity associated with adoption of social roles in clown anemonefish

    Lili F Vizer, Douglas Alvarado ... Pete Buston
    During the establishment of size-based dominance hierarchies in clown anemonefish, an individual's social context shapes its growth trajectory through coordinated changes in feeding behavior, aggressive behaviors, and gene expression.
    1. Biochemistry and Chemical Biology

    Cell cycle-coupled CK1δ turnover, autoinhibition, and activity

    Fidel Emmanuel Serrano, Bianca Ruppert ... Michael Brunner
    In light of recent observations of how CK1δ is dynamically regulated, kinase activity and abundance are also regulated throughout the cell cycle primarily through phosphorylation at the C-terminal tail.
    1. Cell Biology
    2. Physiology

    Primary cilia in the growing limb are preferentially orientated, uncoupled from centriolar position

    Theana Johnson, Swati Midha ... Angus KT Wann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cell Biology

    Pre-rRNA represses gene transcription in the XY body of male germ cells

    Linlin Chen, Xiaochen Gai ... Xiaochun Yu
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    1. Neuroscience

    Dopaminergic Neurons Linking Threat Processing to Cardiac Modulation and Locomotor Responses

    Masato Tsuji, Daisuke Jinkoma ... Kazuo Emoto
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

    Bas de Boer, Thomas D Lamme ... Christopher T Schafer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Ecology

    Male chickadees with better spatial cognition sire more extra-pair young

    Carrie L Branch, Benjamin R Sonnenberg ... Vladimir V Pravosudov
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling