Highlights

  • Mapping regulatory DNA

    Cis-regulatory elements in the large genome of Parhyale hawaiensis can be identified by integrating chromatin accessibility and sequence conservation data.

    Gillian Forbes, Emilia Skafida ... Mathilde Paris
    Research Article

  • Hypoxia to healthspan

    Genetic tools highlight potential signalling components underlying hypoxia-induced longevity in C. elegans.

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Reviewed Preprint Updated

  • Symbionts shape pest traits

    Novel endosymbiotic bacteria have contrasting effects on the performance and dispersal of Russian wheat aphids and on the severity of damage caused to cereal host plants.

    Xinyue Gu, Alex Gill ... Ary A Hoffmann
    Reviewed Preprint

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Uncertainty-aware quantitative analysis of the structure and dynamics of T cell receptor repertoires

    Simo Kitanovski, Kai Wollek, Daniel Hoffmann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Hippocampal and prefrontal contributions to memory-guided navigation depend on task epoch

    Tora Dohi, Lucy Anderson ... Ipshita Zutshi
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Top-down processing alone activates the early somatosensory nuclei

    Paige Howell, Lynn Farner ... Sanne Kikkert
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets

    Peter Chovanec, Shiyang He, Yi Yin
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology

    A high-throughput assay for the measurement of Ca2+ oscillations and insulin release from uniformly sized mouse β-cell (MIN6) spheroids

    Stijn Robben, Patricia Davidson ... Thomas Voets
    High-throughput monitoring of glucose-evoked calcium oscillations in uniform 3D β-cell spheroids enables efficient discovery of compounds that enhance insulin secretion.
    1. Genetics and Genomics
    2. Physiology

    NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

    Pedro A Perez, Chung-Chih Liu ... Supriya Srinivasan
    NK2R is a molecular switch linking tachykinin signaling to intestinal lipid handling, mucosal inflammation and gut microbiota, positioning NK2R-targeted peptide therapeutics for cardiometabolic and inflammatory bowel diseases.
    1. Genetics and Genomics

    Dietary Restriction Impacts Peripheral Diurnal Rhythms Important for Longevity in Drosophila

    Dae-Sung Hwangbo, Yong-Jae Kwon ... Ravi Allada
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Incomplete
    1. Neuroscience

    Limitations of pupil diameter as a proxy for modes of locus coeruleus activity

    Lowell W Thompson, Joshua I Gold
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Neurofeedback enhances a neural signature of selective attention to speech in cocktail-party settings

    Ram K Pari, Marina Inyutina ... Benedikt Zoefel
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Reassessing Choice Probability: What 59 Macaque Studies Tell Us About Decision-Related Activity in Visual Cortex

    Anton Pletenev, Richard T Born ... Ralf M Haefner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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Magazine

    1. Genetics and Genomics
    2. Developmental Biology
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    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  2. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  3. Close-up of an iris

    Episode 105: September 2026

    1. Cell Biology
    2. Computational and Systems Biology

    Philosophy of Biology: The power of theory in the life sciences

    Jacob L Fine, Finn Creeggan ... Adam MR Groh
    1. Genetics and Genomics

    Environmental Learning: How experience shapes individuality

    Bassem A Hassan

  6. Point of View: Scientific writing is not a murder mystery

    Charlotte A Dodson
    1. Neuroscience

    Visual Categorization: How monkeys carve up the visual world

    Binxu Wang
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
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  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
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  19. Structural Biology and Molecular Biophysics
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