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Latest research

    1. Biochemistry and Chemical Biology

    A native chemical chaperone in the human eye lens

    Eugene Serebryany et al.
    The human eye lens imports and concentrates within itself a naturally abundant small molecule that inhibits cataract-associated aggregation of an eye lens protein before the aggregates get large enough to scatter light.
    1. Evolutionary Biology
    2. Neuroscience

    Evolutionary convergence of a neural mechanism in the cavefish lateral line system

    Elias T Lunsford et al.
    The underlying neurophysiology of the lateral line system in blind cavefish (Astyanax mexicanus) has evolutionarily converged on elevated afferent neuron activity and partial loss of function in inhibitory efferent neurons, both of which contribute to enhanced sensitivity to flow stimuli.
    1. Developmental Biology

    Species-specific sensitivity to TGFβ signaling and changes to the Mmp13 promoter underlie avian jaw development and evolution

    Spenser S Smith et al.
    Multiple levels of gene regulation in the TGFβ signaling pathway mediate the expression of Mmp13, establish species-specific domains of bone resorption, and likely generate evolutionary variation in jaw length.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Generation of vascularized brain organoids to study neurovascular interactions

    Xin-Yao Sun et al.
    A vessel and brain fusion organoid model provides a platform for the study of interactions between neuronal and non-neuronal components during brain development and functioning.
    1. Microbiology and Infectious Disease

    High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy

    Claudia A Vera-Arias et al.
    A novel high-throughput method for Plasmodium falciparum genotyping will enable malaria control programs to make informed decisions about the best tool to use for the diagnosis of malaria.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Admixture of evolutionary rates across a butterfly hybrid zone

    Tianzhu Xiong et al.
    Genetic barriers to gene flow maintain divergent linked substitution rates in hybridization.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor

    Ritvija Agrawal et al.
    KASH5 uses an EF-hand domain to directly interact with the light intermediate chain of dynein, promotes processive dynein motility, and facilitates dynein recruitment to the nuclear envelope during prophase I of meiosis.