PTH signaling in bone

Latest research

1. 1. Microbiology and Infectious Disease

   Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment

   Abdirahman I Abdi, Fiona Achcar ... Matthias Marti

   We investigate how parasites adapt to environmental changes in the context of changing transmission patterns, for example by increasing investment in transmission stages at low endemicity such as elimination settings.
2. 1. Neuroscience

   Distinct roles of forward and backward alpha-band waves in spatial visual attention

   Andrea Alamia, Lucie Terral ... Rufin VanRullen

   Covert visual attention modulates alpha-band traveling waves propagating from frontal to occipital regions in both hemispheres, yet it modulates waves propagating in the opposite direction (occipital to frontal) only in the presence of visual stimulation.
3. 1. Neuroscience

   Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

   Kieran A. Boyle, Erika Polgár ... Andrew J. Todd
4. 1. Genetics and Genomics
   2. Medicine

   Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2,600 disease traits

   Joshua K Park, Shantanu Bafna ... Ron Do
5. 1. Cell Biology

   Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

   Danielle B Buglak, Pauline Bougaran ... Victoria L Bautch

   The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function.
6. 1. Stem Cells and Regenerative Medicine
   2. Developmental Biology

   Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids

   Jaydeep Sidhaye, Philipp Trepte ... Jürgen A Knoblich

   RNA-protein multiome approach helps to discover that the posttranscriptional regulation of the translational machinery is crucial for the fidelity of cortical development.
7. 1. Structural Biology and Molecular Biophysics

   Structural insight into the stabilization of microtubules by taxanes

   Andrea E Prota, Daniel Lucena-Agell ... J Fernando Díaz

   Crystal structures of taxane-tubulin complexes allow the understanding of the interaction of paclitaxel (Taxol) with its cellular target in atomic detail and assess the structural determinants for binding.
8. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly

   Hirohide Takahashi, Toshiki Yamada ... Erkan Karakas

   The cryo-electron microscopy structures of an LRRC8C chimera with native channel properties reveal the diverse oligomeric assembly and suggest that lipids may play a role in gating in volume-regulated anion channels.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics

   Sean M Braet, Theresa SC Buckley ... Ganesh S Anand

   Structural mass spectrometry reveals conformational changes in emerging SARS-CoV-2 spike protein variants that correlate with increased viral fitness.
10. 1. Neuroscience

    Inhibition drives habituation of a larval zebrafish visual response

    Laurie-Anne Lamiré, Martin Haesemeyer ... Owen Randlett