Latest research

1. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   circFL-seq reveals full-length circular RNAs with rolling circular reverse transcription and nanopore sequencing

   Zelin Liu et al.

   Accurate identification and quantification of various circRNA isoforms.
2. 1. Cell Biology
   2. Developmental Biology

   Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

   Maureen C Lamb et al.

   Collectively migrating cells control their stiffness by Fascin-dependent control of Myosin activity, and this migratory cell stiffness regulates Myosin activity and stiffness within the cellular substrate to ultimately promote migration.
3. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

   Seyi Falekun et al.

   Malaria parasites have simplified and adapted their mitochondrial metabolism to lack fatty acid synthesis but retain an unusual acyl carrier protein required for stability of the core iron-sulfur cluster biogenesis complex.
4. 1. Neuroscience

   NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

   Theresa Pohlkamp et al.

   Genetic disruption of sodium-hydrogen exchanger 6 (NHE6) reduces amyloid plaques in humanized Alzheimer's disease mouse models and restores normal synaptic responses to neuromodulatory input in humanized ApoE4-expressing animals.
5. 1. Plant Biology

   A novel bivalent chromatin associates with rapid induction of camalexin biosynthesis genes in response to a pathogen signal in Arabidopsis

   Kangmei Zhao et al.

   A previously uncharacterized type of bivalent chromatin plays an important role controlling the timely induction of genes involved in making a potent defense metabolite upon a pathogen signal in Arabidopsis.
6. 1. Immunology and Inflammation

   Redefining innate natural antibodies as important contributors to anti-tumor immunity

   Kavita Rawat et al.

   Natural antibodies play a fundamental role in anti-cancer immunity.
7. 1. Biochemistry and Chemical Biology

   Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

   Maria Carmela Filomena et al.

   Ablation of the sarcomeric protein myopalladin (MYPN), associated with human cardiomyopathies, results in dilated cardiomyopathy, which is severely aggravated by biomechanical stress, suggesting that skeletal myopathy patients carrying MYPN loss-of-function mutations may develop cardiomyopathy under conditions of cardiac stress.
8. 1. Medicine
   2. Microbiology and Infectious Disease

   An open label randomized controlled trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis

   Nguyen Thi Thuy Ngan et al.

   Despite evidence of significant anti-cryptococcal activity in vitro and animal models, including synergy with other antifungal agents, high-dose tamoxifen has no impact on cerebrospinal fluid sterilization in cryptococcal meningitis.
9. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD

   Ginto George et al.
10. 1. Cell Biology
    2. Immunology and Inflammation

    Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

    Shannon Rausser et al.