Highlights

  • ERK3 in control

    The kinase ERK3 influences the motility of tumor cells by controlling a previously unknown regulatory pathway.

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    Research Advance Updated
  • Seeing MHC activation in vivo

    MHC reporter mice can be used to analyse inflammation and neurodegeneration, and to study diseases such as multiple sclerosis.

    Em P Harrington, Riley B Catenacci ... Peter A Calabresi
    Tools and Resources Updated
  • Update on eLife’s new model

    In the first three months, we have seen consistent submissions and positive feedback from authors.

    Inside eLife

Latest research

    1. Neuroscience

    Early-life experience reorganizes neuromodulatory regulation of stage-specific behavioral responses and individuality dimensions during development

    Reemy Ali Nasser, Yuval Harel, Shay Stern
    Early-life experiences and neuromodulatory mechanisms shape discontinuous behavioral plasticity across developmental stages and modify the spectrum of long-term individuality patterns within isogenic populations.
    1. Cancer Biology

    Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes

    Aojia Zhuang, Aobo Zhuang ... Chen Ding
    Based on the proteomics results, T1 CRC LNM prediction models were built using machine learning, the functional differences and biomarkers between LNM-negative and LNM-positive patients were revealed.
    1. Physics of Living Systems

    Vein fate determined by flow-based but time-delayed integration of network architecture

    Sophie Marbach, Noah Ziethen ... Karen Alim
    Relative hydraulic resistance, shear rate, and pressure in a vascular network integrate the network's architecture via fluid flow, and determine vein dynamics, with a time delay, in the prototypical organism Physarum polycephalum.
    1. Genetics and Genomics

    Limitations of principal components in quantitative genetic association models for human studies

    Yiqi Yao, Alejandro Ochoa
    It is always better to use mixed effects models over principal components association regression for genetic association studies of continuous traits, since the former models family structure and close relatives are always found in real human studies.
    1. Neuroscience

    Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

    Surjeet Mastwal, Xinjian Li ... Kuan Hong Wang
    1. Microbiology and Infectious Disease

    Extensive re-modelling of the cell wall during the development of Staphylococcus aureus bacteraemia

    Edward J.A. Douglas, Nathanael Palk ... Ruth C. Massey