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Latest research

    1. Cell Biology
    2. Chromosomes and Gene Expression

    Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

    Michael Chas Sumner et al.
    Measuring and simulating chromatin dynamics reveals that repositioning of genes to the nuclear pore is neither active nor vectorial, but reduces sub-diffusion and coordinates movement between loci on different chromosomes.
    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof et al.
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
    1. Epidemiology and Global Health

    High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing

    William S Hart et al.
    Fitting a mechanistic model to data from SARS-CoV-2 source-recipient pairs generates improved estimates of changes in infectiousness during infection, indicating substantial transmission shortly before symptom onset.
    1. Cancer Biology
    2. Cell Biology

    KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

    Chaitra Rao et al.
    A key Ras-driven signaling pathway stimulates the preferential translation of an effector, EPSTI1, that is both necessary and sufficient for the epithelial-to-mesenchymal transition-like phenotype in colorectal cancer cells.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin et al.
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Cell Biology

    Micron-scale geometrical features of microtubules as regulators of microtubule organization

    Nandini Mani et al.
    Micron-scale geometrical features of individual microtubule polymers and polymer networks encode information that guides the self-organization of microtubules into specialized structures for diverse cellular functions such as cell division and signaling in eukaryotic cells.