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Latest research

    1. Developmental Biology

    LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility

    Hyang Mi Moon et al.
    Novel insights into LIS1-dependent regulation of cell membrane contractility and cleavage axis specification identify a key molecular network regulating mitoses of neural progenitors and somatic cells during development.
    1. Human Biology and Medicine

    A synthetic dataset primer for the biobehavioural sciences to promote reproducibility and hypothesis generation

    Daniel S Quintana
    Sharing synthetic datasets that mimic original datasets that could not otherwise be made publicly available can help ensure reproducibility and facilitate data exploration while maintaining participant privacy.
    1. Developmental Biology

    Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

    Taifeng Zhou et al.
    Mechanosensitive channels Piezo1/2 are required for osteoblast differentiation from progenitors by sensing fluid sheer stress and matrix rigidity and regulating NFATc1, YAP1 and ß-catenin activities through Ca2+ stimulated phosphatase calcineurin.
    1. Cell Biology

    Competition between kinesin-1 and myosin-V defines Drosophila posterior determination

    Wen Lu et al.
    Posterior determination of Drosophila oocyte is defined by competition between kinesin-1 removing posterior determinants from the cortex and myosin-V anchoring them.
    1. Structural Biology and Molecular Biophysics

    A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

    Zev A Ripstein et al.
    Understanding of bacterial protein degradation is illuminated by cryo-EM structures of the substrate-bound ClpXP complex from Neisseria meningitidis at 2.3 to 3.3 Å resolution.
    1. Structural Biology and Molecular Biophysics

    Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

    Xue Fei et al.
    Cryo-EM structures of the ClpXP protease reveal how protein substrates are bound, show how spiral ClpX hexamers bind symmetry-mismatched heptameric ClpP rings, and suggest mechanisms for processive substrate translocation.