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Latest research

    1. Structural Biology and Molecular Biophysics

    Filamentation modulates allosteric regulation of PRPS

    Huan-Huan Hu et al.
    Cryo-EM structures of two types of prokaryotic Phosphoribosyl pyrophosphate synthase filaments reveal that filamentation into cytoophidia provides a new layer of metabolic regulation.
    1. Immunology and Inflammation

    Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

    Laura Medina-Ruiz et al.
    The use of multi-chemokine receptor reporter mice helps to unravel the dynamics of receptor involvement in leukocyte migration in vivo and suggests specificity, rather than redundancy, in receptor use.
    1. Epidemiology and Global Health

    Projected resurgence of COVID-19 in the United States in July—December 2021 resulting from the increased transmissibility of the Delta variant and faltering vaccination

    Shaun Truelove et al.
    Multi-model ensembling projected that the Delta variant would lead to a substantial COVID-19 resurgence in the US, with higher vaccination uptake being a critical factor for limiting transmission and impact between states.
    1. Developmental Biology
    2. Neuroscience

    Cd59 and inflammation regulate Schwann cell development

    Ashtyn T Wiltbank et al.
    Cd59 and developmental inflammation are key players in myelinating glial cell development, highlighting the collaboration between glia and the innate immune system to ensure normal neural development.
    1. Biochemistry and Chemical Biology

    Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex

    Kanwal Kayastha et al.
    The cryo-EM structural and functional analyses reveals the lactate dehydrogenase/electron-transferring flavoprotein (Ldh-EtfAB) in its enzymatically active form and the geometry of the confurcating flow of two energetically spitted electrons via 2 FAD and 1 [4Fe-4S] cluster to a central FAD.
    1. Cell Biology
    2. Immunology and Inflammation

    Tongue immune compartment analysis reveals spatial macrophage heterogeneity

    Ekaterini Maria Lyras et al.
    The tongue is a unique barrier organ, which is constantly exposed to environmental pathogens, and therefore is expected to host an immune cell network ensuring local immune defence, which we characterised during development, health, and disease.
    1. Cell Biology

    Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami

    Shimaa A Abdellatef et al.
    A pair of microtubules, ensembles of oppositely oriented axonemal dyneins, and inter-microtubule crosslinkers are the minimum components needed for oscillation and repetitive bending motions.