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Latest research

    1. Microbiology and Infectious Disease

    Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape

    Sophie R Sichel, Benjamin P Bratton, Nina R Salama
    The helical cell shape of Helicobacter pylori depends on the polymerizing cytoskeletal protein CcmA’s recruitment to the cell envelope by Csd5 and CcmA’s indirect stabilization of a periplasmic cell wall hydrolase via interactions with the transmembrane protein Csd7.
    1. Developmental Biology
    2. Neuroscience

    Photoreceptors generate neuronal diversity in their target field through a Hedgehog morphogen gradient in Drosophila

    Matthew P Bostock, Anadika R Prasad ... Vilaiwan M Fernandes
    Photoreceptors diversify their target field at long range through a graded signal.
    1. Developmental Biology
    2. Neuroscience

    Differentiation signals from glia are fine-tuned to set neuronal numbers during development

    Anadika R Prasad, Inês Lago-Baldaia ... Vilaiwan M Fernandes
    Extrinsic signals establish an invariant and stereotyped pattern of neuronal differentiation and programmed cell death in the Drosophila visual system.
    1. Cell Biology

    PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

    Gina M LoMastro, Chelsea G Drown ... Andrew Jon Holland
    Genetically engineered mouse models show that PLK4 protein and kinase activity are essential for multiciliogenesis, demonstrating that the early steps of centriole assembly are conserved between cycling and multiciliated cells.
    1. Cell Biology
    2. Genetics and Genomics

    The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat

    Shawn P Shortill, Mia S Frier ... Elizabeth Conibear
    The yeast VARP homolog forms a new sorting nexin complex that promotes its own membrane recruitment through GEF activity and regulates the distribution of endosomal proteins.
    1. Cell Biology

    Consequences of PDGFR a + fibroblast reduction in adult murine hearts

    Jill T Kuwabara, Akitoshi Hara ... Michelle D Tallquist
    1. Neuroscience

    Non-rapid eye movement sleep determines resilience to social stress normal

    Brittany J Bush, Caroline Donnay ... J Christopher Ehlen
    1. Developmental Biology

    Regulation of Nodal signaling propagation by receptor interactions and positive feedback

    Hannes Preiß, Anna C Kögler ... Patrick Müller