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Latest research

    1. Cancer Biology

    Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

    Teresa WM Fan et al.
    Pembrolizumab activates innate immune metabolism and function in primary human non-small cell lung cancer, whereas Pembrolizumab and beta-glucan synergize in enhancing immune metabolism and tumoridical action in brain-metastasized lung cancer.
    1. Structural Biology and Molecular Biophysics

    Structural insights into the activation of human calcium-sensing receptor

    Xiaochen Chen et al.
    The cryo-electron microscopy structures of inactive and active states of calcium-sensing receptor (CaSR) reveal the activation mechanisms of CaSR.
    1. Developmental Biology
    2. Evolutionary Biology

    Gamete expression of TALE class HD genes activates the diploid sporophyte program in Marchantia polymorpha

    Tom Dierschke et al.
    The ancestral mechanism to activate diploid gene expression via homeodomain transcription factors was retained in liverworts, an early diverging land plant lineage, and subsequently co-opted during evolution of the diploid sporophyte body.
    1. Evolutionary Biology

    Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

    Angela M Phillips et al.
    CR9114, one of the most broadly neutralizing anti-influenza antibodies characterized to date, acquires affinity to divergent HA subtypes sequentially, due to higher order interactions between the nested sets of mutations required for binding each distinct subtype.
    1. Genetics and Genomics

    Human genetic analyses of organelles highlight the nucleus in age-related trait heritability

    Rahul Gupta et al.
    Although cellular organelles show a functional deterioration in aging, genetic loci associated with common age-associated disease instead nominate nuclear transcription factors across several age-related diseases.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

    Gaspare La Rocca et al.
    A new genetically engineered mouse strain is described in which miRNA activity can be acutely and reversibly inhibited, showing that in a subset of adult tissues miRNA activity is dispensable under homeostatic conditions but becomes essential during tissue regeneration.
    1. Medicine

    Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing

    Corrado Sandini et al.
    A novel methodical approach aimed at improving translation of network analyses to psychopathology provides an intuitive representation of longitudinal clinical pathways between symptoms and can assist in predicting prognosis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments

    Quentin M Smith et al.
    Direct single molecule visualization of striated muscle relaxation using thin filament tightropes reveals the concerted release of myosins, with implications for models of muscle function.