Latest research

1. 1. Biochemistry and Chemical Biology

   Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones

   Iti Kapoor et al.

   Biochemical and structural biological analyses show how bacteria can recognize hormones that control the production of important secondary metabolites such as antiparasitics and antibiotics.
2. 1. Neuroscience

   Estimating and interpreting nonlinear receptive field of sensory neural responses with deep neural network models

   Menoua Keshishian et al.

   A comprehensive, data-driven and interpretable nonlinear computational modeling framework based on deep neural networks uncovers different nonlinear transformations of speech signal in the human auditory cortex.
3. 1. Neuroscience

   A Matlab-based toolbox for characterizing behavior of rodents engaged in string-pulling

   Samsoon Inayat et al.

   Analysis methods for video data of rodents engaged in string-pulling behavior have been developed and used to highlight differences in motion profiles of Swiss Webster and C57Bl/6 mice.
4. 1. Developmental Biology

   Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors in Drosophila

   Satish Kumar Tiwari et al.

   Genetic and molecular analyses reveal the decisive role of fatty acid oxidation (FAO) acting downstream to the ROS-JNK circuit essential for hemocyte progenitor differentiation in Drosophila..
5. 1. Neuroscience

   A size principle for recruitment of Drosophila leg motor neurons

   Anthony W Azevedo et al.

   Motor neurons controlling the leg of the fruit fly exhibit a gradient of physiological and functional properties that correlate with the order in which they fire during behavior.
6. 1. Neuroscience

   Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

   Nathan Cermak et al.

   Simultaneous quantification of each of the main motor programs in the roundworm C. elegans yields new insights into the neural mechanisms that coordinate animal behavior.
7. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

   Lukas S Stelzl et al.

   The cysteine pair oxidation state in nDsbD acts as a ‘switch’ controlling the presence or absence of frustration in the active-site and determining the dynamic behavior of the cap loop.
8. 1. Genetics and Genomics
   2. Neuroscience

   An adipokine feedback regulating diurnal food intake rhythms in mice

   Anthony H Tsang et al.
9. 1. Neuroscience

   Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice

   Li Wang et al.

   Electrical activity at the gonadotropin-releasing hormone (GnRH) neuron cell body and proximal dendrites is not required for the pulsatile secretion of GnRH that controls fertility.
10. 1. Neuroscience

    Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

    Jui-Yi Hsieh et al.