Latest research

1. 1. Cell Biology
   2. Genetics and Genomics

   Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

   Maja Kneissig et al.

   A method to generate human cells with massive chromosomal aberrations on a specific chromosome allows analysis of their consequences.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

   Adriana E Golding et al.

   Through visualization of directly-labeled RhoGTPase both in vitro and in vivo, RhoGDI is found to spatiotemporally regulate RhoGTPase activity through the extraction of active RhoGTPase.
3. 1. Cell Biology
   2. Developmental Biology

   Telophase correction refines division orientation in stratified epithelia

   Kendall J Lough et al.
4. 1. Cancer Biology
   2. Cell Biology

   Axon-like protrusions promote small cell lung cancer migration and metastasis

   Dian Yang et al.
5. 1. Evolutionary Biology
   2. Plant Biology

   Asymmetrical diversification of the receptor-ligand interaction controlling self-incompatibility in Arabidopsis

   Maxime Chantreau et al.

   In-planta ancestral protein resurrection of the female determinant of self-incompatibility specificity in Arabidopsis halleri demonstrates that two allelic variants currently segregating as distinct receptor-ligand combinations diverged through an asymmetrical process.
6. 1. Cancer Biology
   2. Human Biology and Medicine

   Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape

   Chen Farhy et al.

   A novel phenotypic screening platform based on immunofluorescent imaging of histone modifications enables accurate identification of cell fates and environmental perturbations.
7. 1. Human Biology and Medicine
   2. Immunology and Inflammation

   A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

   Enas Abu-Shah et al.

   The use of advanced 3D culture systems with engineered quiescent human T-cells, mimicking in vivo cellular dynamics, paves the way to a new era of much needed pre-clinical research tools.
8. 1. Neuroscience

   Calretinin positive neurons form an excitatory amplifier network in the spinal cord dorsal horn

   Kelly M Smith et al.

   A signal amplifier network that transmits mechanical pain is delineated through characterising an excitatory interneuron population in the spinal cord dorsal horn and defining the postsynaptic populations they regulate.
9. 1. Genetics and Genomics
   2. Human Biology and Medicine

   Single cell transcriptional signatures of the human placenta in term and preterm parturition

   Roger Pique-Regi et al.
10. 1. Human Biology and Medicine

    Straightjacket/α2δ3 deregulation is associated with cardiac conduction defects in myotonic dystrophy type 1

    Emilie Auxerre-Plantié et al.

    Drosophila DM1 models suggest that elevated cardiac expression of straightjacket/α2δ3, a regulatory subunit of voltage-gated calcium channel, contributes to cardiac conduction defects in DM1.