Latest research

1. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium

   Madeline Sandoval et al.

   Skin epithelium can tolerate oncogene-expressing clones through a novel cellular mechanism of inter-clonal competition between renewing progenitors along the clone's edge and differentiating progenitors within the clone's core.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   ARL3 activation requires the co-GEF BART and effector-mediated turnover

   Yasmin ElMaghloob et al.

   BART is a co-GEF for ARL3 and maintains the active ARL3-GTP until it is recycled by ARL3 effectors.
3. 1. Cell Biology
   2. Computational and Systems Biology

   Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

   Peter Jan Hooikaas et al.

   Kinesin-4 KIF21B promotes rapid reorientation of the microtubule network during formation of immunological synapse in T cells by acting as a pausing and catastrophe-inducing factor that keeps microtubules short.
4. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Molecular basis for the adaptive evolution of environment-sensing by H-NS proteins

   Xiaochuan Zhao et al.

   Combining in silico and experimental approaches to identify and understand the residue changes in the H-NS protein that allowed bacteria to adapt environment-sensing to different habitats.
5. 1. Neuroscience

   Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants

   Jakob Voigts et al.

   Changing which layer 6 neurons are active during sensory tasks disrupts the detection and encoding of changes, but still allows integration of sensory information in the absence of changes.
6. 1. Cell Biology
   2. Immunology and Inflammation

   Deep-learning-based three-dimensional label-free tracking and analysis of immunological synapses of CAR-T cells

   Moosung Lee et al.

   Rapid, label-free, volumetric, and automated assessment of the immunological synapse dynamics is demonstrated by combining optical diffraction tomography and deep-learning-based segmentation, providing a new option for immunological research.
7. 1. Evolutionary Biology
   2. Microbiology and Infectious Disease

   Collateral sensitivity associated with antibiotic resistance plasmids

   Cristina Herencias et al.
8. 1. Developmental Biology
   2. Neuroscience

   Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

   Maria Schörnig et al.
9. 1. Genetics and Genomics
   2. Plant Biology

   The Arabidopsis active demethylase ROS1 cis-regulates defense genes by erasing DNA methylation at promoter-regulatory regions

   Thierry Halter et al.
10. 1. Stem Cells and Regenerative Medicine

    Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

    Andrew W DeVilbiss et al.