Latest research

1. 1. Neuroscience

   Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain

   Lynne Chantranupong et al.

   Extensive mass spectrometry-based profiling of polar metabolites within synaptic vesicles that are rapidly isolated either from cultured mouse neurons or directly from mouse brains reveals their neurotransmitter composition.
2. 1. Neuroscience

   Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior

   Igor Gridchyn et al.

   The optogenetic manipulation of hippocampal neuronal circuit activity revealed plastic changes of pyramidal-interneuron connections in behaving animals, which were primarily governed by the firing rate change of postsynaptic interneurons.
3. 1. Developmental Biology

   Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

   Yuto Yoshinari et al.

   Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.
4. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase

   Xiakun Chu et al.
5. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Conditional protein tagging methods reveal highly specific subcellular distribution of ion channels in motion-sensing neurons

   Sandra Fendl et al.
6. 1. Developmental Biology

   Multiscale cardiac imaging spanning the whole heart and its internal cellular architecture in a small animal model

   Graham Rykiel et al.
7. 1. Neuroscience

   Functional links between sensory representations, choice activity, and sensorimotor associations in parietal cortex

   Ting-Yu Chang et al.
8. 1. Ecology
   2. Evolutionary Biology

   Sex-specific effects of cooperative breeding and colonial nesting on prosociality in corvids

   Lisa Horn et al.
9. 1. Cell Biology
   2. Neuroscience

   A feedback loop governs the relationship between lipid metabolism and longevity

   Nicole K Littlejohn et al.

   The dual control of adiposity and longevity emerges from a latent intestinal feedback loop which simultaneously augments fat loss and shields lifespan from the deleterious effects of continuous fat oxidation.
10. 1. Neuroscience

    Cannabinoids modulate associative cerebellar learning via alterations in behavioral state

    Catarina Albergaria et al.

    Cannabinoid receptors modulate cerebellar learning, not through direct effects on synaptic plasticity, but as a secondary consequence of their modulation of behavioral state.