Latest research

1. 1. Cell Biology
   2. Computational and Systems Biology

   Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

   Jakub Tomek et al.

   A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.
2. 1. Chromosomes and Gene Expression

   The genetic basis of aneuploidy tolerance in wild yeast

   James Hose et al.

   A single gene allele underlies differences in aneuploidy tolerance in yeast.
3. 1. Neuroscience

   Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine

   Antoine Cherix et al.

   ¹H-Magnetic resonance spectroscopy at 14T reveals a metabolic signature for anti-depressant-like effects of acetyl-L-carnitine in nucleus accumbens of susceptible mouse.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

   James Chen et al.

   Cryo-electron microscopy structures, combined with biochemical experiments, show how the E. coli F element-encoded TraR protein regulates transcription initiation by altering RNA polymerase conformation and conformational heterogeneity.
5. 1. Microbiology and Infectious Disease

   Coordination of humoral immune factors dictates compatibility between Schistosoma mansoni and Biomphalaria glabrata

   Hongyu Li et al.

   A coordinated humoral immune response that includes recognition, effector and cytotoxic factors engages the cell-mediated immune response to defend a snail against infection by schistosome parasites.
6. 1. Biochemistry and Chemical Biology

   The human coronavirus HCoV-229E S-protein structure and receptor binding

   Zhijie Li et al.

   The HCoV-229E coronavirus S-protein accommodates extensive mutational change and possesses hydrophilic subunit interfaces in the S2 region, features that provide new insights into immune evasion, cross-species transmission and membrane fusion.
7. 1. Cell Biology
   2. Developmental Biology

   Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells

   Zhiwei Lu et al.

   Metabolite mediates communication between stem cells and influences stem cell maintenance.
8. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

   Tatyana Bodrug et al.
9. 1. Developmental Biology
   2. Neuroscience

   Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity

   Jennifer A Honeycutt et al.
10. 1. Microbiology and Infectious Disease

    Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase

    Tobias Geiger et al.