eLife works to improve research communication through open science and open technology innovation

Latest research

    1. Cell Biology

    Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ signalling to control glucose-dependent insulin secretion

    Dillon Jevon et al.
    The essential role of focal adhesion kinase in locally regulating insulin secretion and calcium responses in pancreatic beta cells is identified through the use of the pancreatic slice technique.
    1. Neuroscience

    Contractile force assessment methods for in vitro skeletal muscle tissues

    Camila Vesga-Castro et al.
    A standardized comparison of contractile force among in vitro muscle tissues across different platforms requires proper normalization with the contractile area and complementary morphological, maturation, and functional analysis to reduce variability and boost a new generation of engineered constructs.
    1. Structural Biology and Molecular Biophysics

    Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

    Maicon Landim-Vieira et al.
    Analytical techniques and computational models reveal novel post-translational modifications on β-myosin heavy chain in the human hearts and highlight their potential as therapeutic targets.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Epistatic selection on a selfish Segregation Distorter supergene – drive, recombination, and genetic load

    Beatriz Navarro-Dominguez et al.
    African haplotypes of a meiotic drive supergene in Drosophila melanogaster called Segregation Distorter show signs of a recent selective sweep, reduced recombination, and increased genetic load.
    1. Neuroscience

    Human visual gamma for color stimuli

    Benjamin J Stauch et al.
    Colored surfaces induce gamma oscillations in human early visual cortex that are equally strong for red and green colors when L-M cone contrast is controlled for.