Latest research

1. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

   William F Richter et al.

   FLT3-ITD/STAT5A signaling is more sensitive to Dot1L inhibition than the canonical MLL-fusion activated drivers of leukemogenesis, providing a potential therapeutic avenue for one of the most frequent lesions in leukemia.
2. 1. Physics of Living Systems
   2. Structural Biology and Molecular Biophysics

   Calponin-homology domain mediated bending of membrane-associated actin filaments

   Saravanan Palani et al.

   Combination of actin and curly on lipid membranes constitutes a new, minimalistic system to generate high curvature actin rings that can contract upon the action of myosin II filaments.
3. 1. Microbiology and Infectious Disease

   KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

   Rajnish Kumar Singh et al.

   KSHV nullifies hypoxic restriction of DNA replication.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The fluoride permeation pathway and anion recognition in Fluc family fluoride channels

   Benjamin C McIlwain et al.

   In the extremely selective fluoride channels from the bacterial Fluc family, fluoride ions access the pore via two points, an electropositive vestibule and a triad of conserved residues involved in anion recognition.
5. 1. Physics of Living Systems

   Propelling and perturbing appendages together facilitate strenuous ground self-righting

   Ratan Othayoth, Chen Li

   Animals can, and robots should, use different types of appendages together to propel and perturb themselves to self-right when overturned, a strenuous yet crucial locomotor task.
6. 1. Neuroscience

   Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis

   Sayali V Gore et al.

   Chronic dysregulation of matrix-metalloproteinase 9, which is associated with some neurodevelopmental disorders, leads to local hyperconnectivity in the developing brain, resulting in altered sensory processing and increased seizure susceptibility.
7. 1. Epidemiology and Global Health
   2. Genetics and Genomics

   Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

   James A Watson et al.

   Complete blood count data can increase the accuracy of the diagnosis of severe malaria in children in high transmission settings.
8. 1. Developmental Biology
   2. Immunology and Inflammation

   Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

   Xia Liu et al.

   Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control checkpoint for thymocyte β-slection.
9. 1. Microbiology and Infectious Disease

   Revisiting the guidelines for ending isolation for COVID-19 patients

   Yong Dam Jeong et al.

   Compared with the approach isolating COVID-19 patients for a fixed period, the approach using repeated PCR testing mitigates unnecessarily lengthy isolation of patients while minimizing the risk of further transmission.
10. 1. Microbiology and Infectious Disease

    Co-circulation of multiple influenza A reassortants in swine harboring genes from seasonal human and swine influenza viruses

    Pia Ryt-Hansen et al.