Latest research

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Divergent Cl^- and H⁺ pathways underlie transport coupling and gating in CLC exchangers and channels

   Lilia Leisle et al.

   Combined simulations and electrophysiological experiments show that the CLC channels and exchangers form physically distinct and evolutionarily conserved pathways through which Cl^- and H⁺ ions move when crossing biological membranes.
2. 1. Cell Biology

   Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

   Yanan Sun et al.

   Cell biological and genetic studies reveal age-associated alterations of lysosomes and modulation of lysosomal activity by longevity pathways.
3. 1. Neuroscience

   Differences in reward biased spatial representations in the lateral septum and hippocampus

   Hannah S Wirtshafter, Matthew A Wilson

   Reward-related spatial information is preferentially represented in the lateral septum compared to the hippocampus and may be used downstream to direct the animal to rewarded locations.
4. 1. Structural Biology and Molecular Biophysics

   Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump

   Xin Xu et al.

   The structure of the membrane-integrated components of a unique substrate decarboxylation-driven primary-active sodium pump provides insights into its transport mechanism.
5. 1. Cell Biology
   2. Immunology and Inflammation

   Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception

   Stefanie Gryzik et al.

   A novel binning approach provides evidence for super-functional T cells with high activation potential and which exhibit Tfh-like functionalities and can help B cells.
6. 1. Human Biology and Medicine
   2. Neuroscience

   A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

   June K Corrigan et al.

   The metabolic rate of mice is disproportionately affected by the site of experimentation, affecting the phenotypic interpretation of genetically modified strains.
7. 1. Neuroscience

   High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila

   Rui Huang et al.

   Fruit flies fed with high-fats diets are hyper-sensitive to a hunger hormone AKH and exhibit enhanced food-seeking behavior when starved.
8. 1. Neuroscience

   Flexible motor sequence generation during stereotyped escape responses

   Yuan Wang et al.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Mechanisms of nucleotide selection by telomerase

   Matthew A Schaich et al.

   The roles of key telomerase active site residues were elucidated to determine how telomerase selects the correct from the incorrect nucleotide to maintain telomere integrity.
10. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    TGFβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

    Deepak A Kaji et al.