Plasticity and performance

Latest research

1. 1. Evolutionary Biology

   Heterozygote advantage can explain the extraordinary diversity of immune genes

   Mattias Siljestam, Claus Rueffler

   An eco-evolutionary model shows that heterozygote advantage can maintain over 100 major histocompatibility complex alleles, providing a potent explanation for extraordinary immune gene diversity and challenges previous models that predicted limited allele coexistence.
2. 1. Cancer Biology
   2. Computational and Systems Biology

   Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

   Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge

   Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
3. 1. Neuroscience

   The NeuroML ecosystem for standardized multi-scale modeling in neuroscience

   Ankur Sinha, Padraig Gleeson ... Robin Angus Silver

   The NeuroML model description language, with its extensive software ecosystem, supports researchers in the development of FAIR, data-driven, biologically detailed models of neural systems.
4. 1. Immunology and Inflammation

   The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway

   Yalan Jiang, Pingping He ... Xiaoou Shan

   Eugenol has the ability to improve the type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
5. 1. Neuroscience

   Valence and salience encoding in the central amygdala

   Mi-Seon Kong, Ethan Ancell ... Larry S Zweifel

   Central amygdala neurons encode the valence and salience of unconditioned stimuli.
6. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging

   Liza Dahal, Thomas GW Graham ... Xavier Darzacq

   Type II nuclear receptors do not always compete for a limiting pool of their obligate partner RXRa.
7. 1. Neuroscience

   Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins

   Sharon Inberg, Yael Iosilevskii ... Benjamin Podbilewicz
8. 1. Neuroscience

   Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat

   Gyeong Hee Pyeon, Hyewon Cho ... Yong Sang Jo
9. 1. Cell Biology

   Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis

   Shixuan Liu, Ceryl Tan ... Ran Kafri
10. 1. Neuroscience

    Mapping patterns of thought onto brain activity during movie-watching

    Raven Star Wallace, Bronte Mckeown ... Jonathan Smallwood

    Decoding brain activity using a novel paradigm unveils distinct neural signatures of subjective experiences during movie-watching.