PTH signaling in bone

Latest research

1. 1. Immunology and Inflammation

   PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

   Warren Anderson, Fariba Barahmand-pour-Whitman ... David J Rawlings

   Gene editing to generate precisely matched primary human T cell populations demonstrates that the common autoimmune risk allele in the tyrosine phosphatase, PTPN22, promotes signaling in cells expressing a low-avidity, self-reactive TCR specific for a diabetes-associated self-antigen.
2. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

   Ean Spielvogel, Sook-Kyung Lee ... Ronald Swanstrom

   New HIV-1 protease inhibitor designs result in more potent inhibitors with high genetic barriers to resistance and the ability to lead virus evolution down less fit pathways when resistance occurs.
3. 1. Cell Biology

   Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells

   Enric Gutiérrez-Martínez, Susana Benet Garrabé ... Maria F Garcia-Parajo

   Advanced imaging methods reveal that Siglec-1 spatial distribution on mature dendritic cells is regulated by components of the actin polymerization machinery impacting on its engagement to HIV-particles and virus sequestration toward virus-containing compartments.
4. 1. Ecology
   2. Evolutionary Biology

   Multiple preferred escape trajectories are explained by a geometric model incorporating prey’s turn and predator attack endpoint

   Yuuki Kawabata, Hideyuki Akada ... Paolo Domenici

   The mathematical model incorporating new parameters explains multimodal distributions in escape direction (i.e., multiple preferred escape trajectories), which are previously observed in various animal taxa.
5. 1. Developmental Biology

   The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice

   Ke Xu, Xianwei Su ... Hongbin Liu

   SSH2, a Slingshot phosphatase required for male fertility, participates in acrosome biogenesis via the control of actin remodeling during spermatid development.
6. 1. Biochemistry and Chemical Biology

   High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display

   Allyson Li, Rashmi Voleti ... Neel H Shah

   A high-throughput method to profile tyrosine kinases and phosphotyrosine recognition domains reveals new rules for sequence specificity and maps the effects of mutations on the recognition of tyrosine phosphorylation sites.
7. 1. Evolutionary Biology
   2. Microbiology and Infectious Disease

   Rescue of Escherichia coli auxotrophy by de novo small proteins

   Arianne M Babina, Serhiy Surkov ... Michael Knopp

   De novo-generated small proteins can cause deattenuation of an amino acid biosynthetic operon by direct protein–RNA interactions.
8. 1. Developmental Biology
   2. Genetics and Genomics

   A timer gene network is spatially regulated by the terminal system in the Drosophila embryo

   Erik Clark, Margherita Battistara, Matthew A Benton

   A retracting gradient of the transcription factor Tailless spatiotemporally patterns the Drosophila tail region by modulating the intrinsic dynamics of a regulatory network involving the timer genes caudal, Dichaete, and odd-paired.
9. 1. Computational and Systems Biology
   2. Neuroscience

   Multilayer brain networks can identify the epileptogenic zone and seizure dynamics

   Hossein Shahabi, Dileep R Nair, Richard M Leahy

   Aging and the duration of epilepsy can intensify the high-frequency desynchronization between the epileptogenic zone and the rest of the brain in early to mid-seizure.
10. 1. Neuroscience

    A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila

    Izumi Oikawa, Shu Kondo ... Ken Honjo