Highlights

  • Exploring hidden hearing loss

    The degeneration of neurons in the cochlea underlies the hearing difficulties reported by adults who have normal audiograms when their hearing is tested.

    Maggie E Zink, Leslie Zhen ... Aravindakshan Parthasarathy
    Research Article
  • Early influences on cell fate

    Cells that polarize early during the 8-cell stage of development in mouse embryos are more likely to become part of the placenta.

    Adiyant Lamba, Meng Zhu ... Magdalena Zernicka-Goetz
    Reviewed Preprint Updated
  • Aggression in female gorillas

    Female-on-female aggression in gorillas depends on the relative numbers of males and females in the group, and on the reproductive state of the gorilla being aggressive.

    Nikolaos Smit, Martha M Robbins
    Research Article

Latest research

    1. Cancer Biology

    SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylation

    Ricardo J Mack, Natasha M Flores ... Or Gozani
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Cell Biology

    Membrane potential modulates ERK activity and cell proliferation

    Mari Sasaki, Masanobu Nakahara ... Fumihito Ono
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Compelling
    • Incomplete
    1. Microbiology and Infectious Disease

    The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

    Junghoon Lee, Scot P Ouellette
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Convincing
    1. Microbiology and Infectious Disease

    An in vitro human vessel model to study Neisseria meningitidis colonization and vascular damages

    Léa Pinon, Mélanie Chabaud ... Guillaume Duménil
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Stimulus-Dependent Theta Rhythmic Activity in Primate V1 Predicts Visual Detection

    Prasakti Tenri Fanyiwi, Beshoy Agayby ... Michael C Schmid
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression

    Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

    Carmen Ruger-Herreros, Lucia Svoboda ... Bernd Bukau
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility

    Shivraj M Yabaji, Vadim Zhernovkov ... Igor Kramnik
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells

    Haibin Liu, Lulu Yu ... Zhi-Ming Zheng
    A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.
    1. Genetics and Genomics

    Identifying in vivo genetic dependencies of melanocyte and melanoma development

    Sarah Perlee, Yilun Ma ... Richard M White
    A zebrafish Cas9 knock-in model enables lineage-specific gene disruption to uncover genetic dependencies in development and disease.