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Highlights

  • ERK3 in control

    The kinase ERK3 influences the motility of tumor cells by controlling a previously unknown regulatory pathway.

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    Research Advance Updated

  • Seeing MHC activation in vivo

    MHC reporter mice can be used to analyse inflammation and neurodegeneration, and to study diseases such as multiple sclerosis.

    Em P Harrington, Riley B Catenacci ... Peter A Calabresi
    Tools and Resources Updated

  • Update on eLife’s new model

    In the first three months, we have seen consistent submissions and positive feedback from authors.

    Inside eLife

Latest research

    1. Cell Biology
    2. Neuroscience

    APOE expression and secretion are modulated by mitochondrial dysfunction

    Meghan E Wynne, Oluwaseun Ogunbona ... Victor Faundez
    Current models of Alzheimer's disease that put mitochondria as an endpoint of disease should be reconsidered because genetic defects affecting mitochondria by themselves can also regulate Alzheimer’s disease risk factor apolipoprotein E (APOE) expression and secretion.
    1. Neuroscience

    The nematode worm C. elegans chooses between bacterial foods as if maximizing economic utility

    Abraham Katzen, Hui-Kuan Chung ... Shawn R Lockery
    A worm with a nervous system of only 302 neurons satisfies the necessary and sufficient conditions for value-based decision making.
    1. Neuroscience

    Spatiotemporal neural dynamics of object recognition under uncertainty in humans

    Yuan-hao Wu, Ella Podvalny, Biyu J He
    Combining 7 Tesla fMRI and MEG data collected during a challenging visual recognition task revealed distinct neural representational formats in ventral visual and frontoparietal regions, and the emergence of recognition-related signals prior to category-related information.
    1. Cancer Biology
    2. Computational and Systems Biology

    GENIUS: GEnome traNsformatIon and spatial representation of mUltiomicS data

    Mateo Sokač, Lars Dyrskjøt ... Nicolai J Birkbak
    1. Computational and Systems Biology
    2. Neuroscience

    Dissecting muscle synergies in the task space

    David Ó’ Reilly, Ioannis Delis
    1. Plant Biology

    Glutaredoxin regulation of primary root growth confers early drought stress tolerance in pearl millet

    Carla de la Fuente, Alexandre Grondin ... Laurent Laplaze
    1. Genetics and Genomics
    2. Neuroscience

    Behavioral dissection of hunger states in Drosophila

    KJ Weaver, S Raju ... SD Pletcher
    1. Neuroscience

    Mesotrode: chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice

    Dongsheng Xiao, Yuhao Yan, Timothy H Murphy
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development

    Tian Yuan, Yifan Wang ... Zhuo Huang
    1. Biochemistry and Chemical Biology

    Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

    F Lolicato, JP Steringer ... W Nickel
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Magazine

    1. Physics of Living Systems

    Vasculature: Exploring the dynamics of vascular adaptation

    Thomas S Shimizu, E Toby Kiers, Howard A Stone
    1. Neuroscience

    Point of View: Beware ‘persuasive communication devices’ when writing and reading scientific articles

    Olivier Corneille, Jo Havemann ... Leon D Lotter
    1. Developmental Biology

    Development: The hidden depths of zebrafish skin

    Yue Rong Tan, Megan Liaw, Chen-Hui Chen
  4. Side-profile of a figure with a cochlear implant, against a yellow background featuring stylized virus particles and sound waves.

    Equity, Diversity and Inclusion: When communication all changed

    John J Dennehy
    1. Neuroscience

    Innate Behavior: A groom with a view

    Jeffrey E Markowitz
    1. Neuroscience

    Hormones: Below the surface of a touch

    Stephanie D Preston, Rosa Muñoz
    1. Chromosomes and Gene Expression

    Gene Expression: Getting off to a good start

    Igor Martianov, Irwin Davidson
  8. See more Magazine articles

Research categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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