Highlights

  • Survival vs. degeneration

    The disruption of activity causes degeneration of entorhinal neurons in a mouse model of Alzheimer’s.

    Rong Zhao, Stacy D Grunke ... Joanna L Jankowsky
    Research Article Updated
  • A new way to publish

    Reviewed Preprints combine the advantages of preprints with the scrutiny offered by peer review; watch our recent webinar to learn more.

    Inside eLife
  • The activation of nucleation

    A conserved centrosomin motif activates the ability of the gamma-tubulin ring complex to nucleate microtubules.

    Michael J Rale, Brianna Romer ... Sabine Petry
    Research Advance

Latest research

    1. Cell Biology
    2. Neuroscience

    Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

    Rituparna Chakrabarti, Lina María Jaime Tobón ... Carolin Wichmann
    Ultrastructural analysis of optogenetically stimulated inner hair cell ribbon synapses reveals normally sized synaptic vesicles and enhanced vesicle docking at the active zone membrane.
    1. Stem Cells and Regenerative Medicine

    Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype

    Antonion Korcari, Anne EC Nichols ... Alayna E Loiselle
    Age-related tendon degeneration is initiated by loss of tenocytes associated with synthesis of high-turnover rate proteoglycans and glycoproteins.
    1. Evolutionary Biology

    Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity

    Priscila S Rothier, Anne-Claire Fabre ... Anthony Herrel
    The diversification of hand bones in mammals was much more dynamic than those of the proximal and intermediate forearm, involving higher morphological diversity, stronger integration, and greater evolutionary lability at distal structures.
    1. Ecology

    Protein feeding mediates sex pheromone biosynthesis in an insect

    Shiyu Gui, Boaz Yuval ... Daifeng Cheng
    Protein feeding stimulates the production of sex pheromones and promotes fly mating in Bactrocera dorsalis.
    1. Computational and Systems Biology
    2. Neuroscience

    A hardware system for real-time decoding of in vivo calcium imaging data

    Zhe Chen, Garrett J Blair ... Hugh T Blair
    DeCalciOn is a low-cost open-source hardware system for real-time in vivo calcium imaging that offers capabilities for online decoding of neural population activity and delivery of short latency closed-loop feedback in freely behaving animals.
    1. Microbiology and Infectious Disease

    Initiation of HIV-1 Gag lattice assembly is required for recognition of the viral genome packaging signal

    Xiao Lei, Daniel Gonçalves-Carneiro ... Paul D Bieniasz
    Initiation of the assembly of HIV-1 particles in infected cells is required to form a subviral structure that recognizes the viral RNA genome for packaging.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Coordinated evolution at amino acid sites of SARS-CoV-2 spike

    Alexey Dmitrievich Neverov, Gennady Fedonin ... Georgii Bazykin
    Analysis of population diversity of SARS-CoV-2 revealed positive epistasis between sites carrying mutations characterizing rapidly expanding lineages.