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Latest research

    1. Developmental Biology
    2. Neuroscience

    Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2ε in vomeronasal sensory neurons

    Jennifer M Lin, Tyler A Mitchell ... Paolo Emanuele Forni
    In vivo genetic experiments show that aberrant expression of a transcription factor can compromise the functionality of neurons which is important to better understand the potential mechanisms underlying neuropathologies.
    1. Neuroscience

    Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA

    David S Jacobs, Madeleine C Allen ... Bita Moghaddam
    A novel approach to studying anxiety reveals that learned anxiety and diazepam treatment have unique roles on prefrontal cortex and ventral tegmental area activity.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness

    Arnaud Carrier, Cécile Desjobert ... Paola B Arimondo
    An original molecular multi-step approach integrating DNA methylome and chromosome-cluster localization cross-analysis identified a DNA methylation signature of patient outcome supporting that the core DNA methylation for a given trait is independent of the physiological context under which it arises.
    1. Immunology and Inflammation

    Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

    Artem Mikelov, Evgeniia I Alekseeva ... Ivan V Zvyagin
    High degree of clonal persistence and excess of inter-individual convergence are observed in human memory B cell repertoires, along with signatures of both negative and positive selection in most abundant clonal lineages.
    1. Computational and Systems Biology
    2. Plant Biology

    Computational modeling and quantitative physiology reveal central parameters for brassinosteroid-regulated early cell physiological processes linked to elongation growth of the Arabidopsis root

    Ruth Großeholz, Friederike Wanke ... Klaus Harter
    The recurring application of computational modelling combined with wet lab experiments identify and predict central regulatory parameters and factors for early cell physiological reactions linked to differential brassinosteroid-modified elongation growth in the root tip of Arabidopsis thaliana.
    1. Neuroscience

    Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells

    Haiwei Zhang, Hongchen Li ... Ping Lv
    In the cochlea, repressor element 1-silencing transcription factor (REST) regulates the expression levels of Kv7.4 and alterations of REST functions result in progressive hearing loss.
    1. Stem Cells and Regenerative Medicine

    In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras

    Bingqiang Wen, Guolun Wang ... Vladimir V Kalinichenko