Latest research

1. 1. Cell Biology
   2. Physics of Living Systems

   Golgi compartments enable controlled biomolecular assembly using promiscuous enzymes

   Anjali Jaiman, Mukund Thattai

   By partitioning promiscuous enzymes across multiple Golgi compartments, eukaryotic cells can tightly control the synthesis of complex sugar oligomers.
2. 1. Neuroscience

   Cortical ChAT⁺ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner

   Adam J Granger et al.

   Most ChAT-expressing interneurons are a subset VIP+ interneurons that differentially release GABA and acetylcholine onto different post-synaptic targets, while a separate population of non-VIP ChAT+ neurons release acetylcholine in mPFC.
3. 1. Physics of Living Systems
   2. Structural Biology and Molecular Biophysics

   Dynamic metastable long-living droplets formed by sticker-spacer proteins

   Srivastav Ranganathan, Eugene I Shakhnovich

   Multi-scale simulations reveal a potential, ATP-independent mechanism resulting in the formation of the long-living multi-droplet state by multi-valent, spacer-sticker proteins.
4. 1. Immunology and Inflammation
   2. Physics of Living Systems

   Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

   Marco Molari et al.

   Detailed and inferred model reproduces B-cell affinity distributions measured in mice immunized according to various protocols and explains non-monotonous effects of antigen dosage on maturation.
5. 1. Epidemiology and Global Health

   Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults

   Flavia Camponovo et al.
6. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement

   Aleksandra Zielińska et al.

   Correct cell wall synthesis in bacteria depends on flotillin-mediated membrane fluidity.
7. 1. Epidemiology and Global Health

   Risk of psychiatric disorders among the surviving twins after a co-twin loss

   Huan Song et al.

   A population-based analysis demonstrates that surviving twins who lose their co-twins by death are at considerably elevated risks of developing psychiatric disorders.
8. 1. Neuroscience

   Sleep is bi-directionally modified by amyloid beta oligomers

   Güliz Gürel Özcan et al.

   Amyloid beta, the major component of plaques in Alzheimer's disease, acutely and reversibly signals to modulate sleep as a function of oligomeric length, independently of neuronal loss.
9. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

   Friederike Roger et al.
10. 1. Computational and Systems Biology
    2. Neuroscience

    Stable task information from an unstable neural population

    Michael E Rule et al.