Latest research

1. 1. Biochemistry and Chemical Biology
   2. Medicine

   The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

   Omar Al Rifai et al.

   In mice, but not in humans, the bone-derived hormone osteocalcin is O-glycosylated, a post-translational modification controlling its half-life in vivo.
2. 1. Cancer Biology
   2. Cell Biology

   Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

   Shima Ghoroghi et al.

   A combination of animal models reveal how the molecular mechanisms of exosome secretion (RalA/B-dependent) are linked to their cargo content and their function in breast cancer pre-metastatic niche formation.
3. 1. Stem Cells and Regenerative Medicine

   Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis

   Katherine T Best et al.
4. 1. Cell Biology

   Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces

   Mihaela Jagrić et al.
5. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   Properdin oligomers adopt rigid extended conformations supporting function

   Dennis V Pedersen et al.
6. 1. Structural Biology and Molecular Biophysics

   Structural basis for transcription complex disruption by the Mfd translocase

   Jin Young Kang et al.
7. 1. Developmental Biology

   Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis

   Junjun Jing et al.

   The molecular regulatory mechanisms that control the interaction between mesenchymal stem cells and transit amplifying cells to maintain tissue homeostasis.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Universal and taxon-specific trends in protein sequences as a function of age

   Jennifer E James et al.

   Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.
9. 1. Neuroscience

   Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons

   Julio D Perez et al.

   Single somata and dendrites of individual rat neurons were laser-captured and sequenced to discover and compare the subcellular transcriptomes, identifying over 4000 mRNAs in GABAergic dendrites.
10. 1. Biochemistry and Chemical Biology

    Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

    Kelsie M Rodriguez et al.