Latest research

1. 1. Evolutionary Biology

   Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants

   Chenlu Di et al.

   Harmful genetic variants at mendelian disease genes slow down adaptation, by interfering with the spread of adaptive variants in a population.
2. 1. Neuroscience

   Neuropsychological evidence of multi-domain network hubs in the human thalamus

   Kai Hwang et al.

   Lesions to the anterior-medio-dorsal thalamus cause widespread behavioral impairments across multiple cognitive domains, suggesting that thalamic hubs are critical for interconnecting diverse cognitive processes.
3. 1. Neuroscience

   Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

   Zhe Zhang et al.

   Postnatal, postsynaptic loss of FMRP specifically weakens callosal synaptic inputs onto L2/3 pyramidal neurons, in requirement ofnormal sensory experience, through downregulating AMPA receptor transmission and without affecting local synaptic inputs during cortical circuit development.
4. 1. Medicine

   Modulation of fracture healing by the transient accumulation of senescent cells

   Dominik Saul et al.

   Senescent cells accumulate in the fracture callus and a reduction in the number of these cells accelerates fracture healing in mice.
5. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

   Alessandro Bonfini et al.

   The nutrient composition of food alters both the size of gut epithelial cells and the ability of the stem cell niche to control tissue turnover, resulting in changes in size at the organ level.
6. 1. Cell Biology

   Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

   Laura Le Pelletier et al.

   Aging is associated with stress-induced senescence of adipose stromal cells, leading to impaired adipogenesis, oxidative stress, mitochondrial dysfunction, and insulin resistance, all being alleviated by metformin treatment of adipose stromal cells.
7. 1. Medicine
   2. Neuroscience

   scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution

   Bilge E Öztürk et al.
8. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   5' modifications improve potency and efficacy of DNA donors for precision genome editing

   Krishna S Ghanta et al.
9. 1. Cell Biology
   2. Medicine

   An experimental test of the effects of redacting grant applicant identifiers on peer review outcomes

   Richard Nakamura et al.
10. 1. Neuroscience

    Finger somatotopy is preserved after tetraplegia but deteriorates over time

    Sanne Kikkert et al.