Highlights

  • The safety-efficiency dilemma

    The Pavlovian fear system has a larger role in decision-making than previously thought, helping to keep it both safe and efficient during exploratory behaviour.

    Pranav Mahajan, Shuangyi Tong ... Ben Seymour
    Research Article
  • The evolution of effectors

    Pathogens that cause abnormal growths called galls in plants rely on effector molecules with structures and targeting strategies that are conserved across evolutionary lineages.

    Soham Mukhopadhyay, Muhammad Asim Javed ... Edel Perez-Lopez
    Tools and Resources
  • Genetic pathways in brown algae

    Life-cycle-related patterns of gene expression are conserved across the brown algae.

    Pélagie Ratchinski, Olivier Godfroy ... J Mark Cock
    Reviewed Preprint Updated
  • Is ‘number sense’ a sense?

    Experiments on domestic chicks shed light on the links between brain lateralization and the left-to-right mental number line.

    Toshiya Matsushima
    Insight
  • Tracing cell fates in embryos

    Differences in the activity of an enzyme called CARM1 influence whether blastomeres become part of the embryo or the placenta.

    Ying Zhang, Qi Chen
    Insight
  • New university partnerships

    eLife is partnering with two leading UK universities on open access agreements that promote a more open and equitable approach to scientific publishing.

    Press Pack

Latest research

    1. Neuroscience

    Eye-specific differences in active zone addition during synaptic competition in the developing visual system

    Chenghang Zhang, Tarlan Vatan, Colenso M Speer
    Revised
    Reviewed Preprint v4
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex

    Abby Silbaugh, Kevin P Koster, Christian Hansel
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Developmental Biology
    2. Computational and Systems Biology

    Anti-resonance in developmental signaling regulates cell fate decisions

    Samuel J Rosen, Olivier Witteveen ... Maxwell Z Wilson
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    PTBP1 Depletion in Mature Astrocytes Reveals Distinct Splicing Alterations Without Neuronal Features

    Min Zhang, Naoto Kubota ... Sika Zheng
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Developmental Biology

    SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice

    Daisuke Mashiko, Shingo Tonai ... Masahito Ikawa
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Developmental Biology

    Glial betaPix is essential for blood vessel development in the zebrafish brain

    ShihChing Chiu, Qinchao Zhou ... Jing-Wei Xiong
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

    Hannah Neiswender, Jessica E Pride ... Graydon B Gonsalvez
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamic interactions

    Rupinder Singh Jandu, Ashim Bhattacharya ... Franck Duong van Hoa
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Medicine
    2. Neuroscience

    Functional Muscle Networks as Biomarkers of Post-Stroke Motor Impairment and Therapeutic Responsiveness

    David O’Reilly, Giorgia Pregnolato ... Giacomo Severini
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete