The activation of nucleation

Latest research

1. 1. Epidemiology and Global Health
   2. Medicine

   The impact of lag time to cancer diagnosis and treatment on clinical outcomes prior to the COVID-19 pandemic: a scoping review of systematic reviews and meta-analyses

   Parker Tope, Eliya Farah ... Eduardo L Franco
2. 1. Developmental Biology

   A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

   Kavitha Chinnaiya, Sarah Burbridge ... Marysia Placzek
3. 1. Neuroscience

   Interacting rhythms enhance sensitivity of target detection in a fronto-parietal computational model of visual attention

   Amélie Aussel, Ian C Fiebelkorn ... Benjamin Rafael Pittman-Polletta PhD
4. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

   Abhinay Ramaprasad, Paul-Christian Burda ... Michael J Blackman

   The malaria parasite uses an enzyme called GDPD to absorb choline, an important nutrient, from the bloodstream and this is essential for the parasite to survive inside the red blood cell.
5. 1. Medicine

   Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts

   Richard C Lauer, Marc Barry ... Wadih Arap

   PRUNE2/PCA3 axis dysregulation is an early, rather than late, event in prostate cancer tumorigenesis.
6. 1. Developmental Biology

   Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

   Florian Schueder, Pierre Mangeol ... Frank Schnorrer

   The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.
7. 1. Developmental Biology

   A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

   Vincent Loreau, Renate Rees ... Dirk Görlich

   A collection of 22 nanobodies against 11 different Drosophila sarcomeric protein epitopes was generated, validated in stainings and for some transgenic fly lines were generated to monitor the dynamics of the sarcomeric proteins in muscles in vivo.
8. 1. Cell Biology
   2. Neuroscience

   Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders

   Lydie Burglen, Evelien Van Hoeymissen ... Joris Vriens

   Newly identified gain-of-function variants indicate TRPM3 as the cause of a spectrum of autosomal dominant neurodevelopmental disorders with frequent cerebellar involvement in humans.
9. 1. Physics of Living Systems

   Geometric control of Myosin-II orientation during axis elongation

   Matthew F Lefebvre, Nikolas H Claussen ... Sebastian J Streichan
10. 1. Structural Biology and Molecular Biophysics

    State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels

    Yein Christina Park, Bharat Reddy ... José D Faraldo-Gómez