Latest research

1. 1. Computational and Systems Biology

   Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets

   Zhuang Liu et al.

   A comprehensive microRNA expression and function landscape of human wounds unraveled miRNAs highly relevant to venous ulcer pathology.
2. 1. Neuroscience

   Flexible and efficient simulation-based inference for models of decision-making

   Jan Boelts et al.

   A new machine learning method makes it possible to efficiently identify the parameters of cognitive models using Bayesian inference, even when only model simulations are available.
3. 1. Cell Biology

   CXCR4^high megakaryocytes regulate host-defense immunity against bacterial pathogens

   Jin Wang et al.

   scRNA-seq identified CXCR4^high MKs can funtionally regulate host-defense immune response against bacterial infection.
4. 1. Cell Biology

   Ubiquitination drives COPI priming and Golgi SNARE localization

   Swapneeta S Date et al.

   The ability of COPI to bind polyubiquitin is a key determinant for SNARE incorporation into intracellular vesicles and for maintenance of a functional Golgi complex.
5. 1. Cell Biology

   Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock

   Eva Kaulich et al.

   Two acid-sensing members of the degenerin/epithelial sodium channel family play distinct roles in controlling different aspects of rhythmic proton and calcium oscillations in the nematode intestine.
6. 1. Stem Cells and Regenerative Medicine

   Generation of functional hepatocytes by forward programming with nuclear receptors

   Rute A Tomaz et al.

   Forward programming of human pluripotent stem cells with a combination of four transcription factors allows the production of functional hepatocytes.
7. 1. Physics of Living Systems

   Learning to predict target location with turbulent odor plumes

   Nicola Rigolli et al.

   Intensity of an odor and timing of its detection are complementary attributes of turbulent plumes and enable robust prediction of the location of a distant target.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Multi-step recognition of potential 5' splice sites by the Saccharomyces cerevisiae U1 snRNP

   Sarah R Hansen et al.
9. 1. Cell Biology
   2. Chromosomes and Gene Expression

   STAG2 promotes the myelination transcriptional programin oligodendrocytes

   Ningyan Cheng et al.
10. 1. Immunology and Inflammation

    Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells

    Joseph Wayne M Fowler et al.