Cylicins and male fertility

Latest research

1. 1. Microbiology and Infectious Disease

   Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

   Qibin Geng, Yushun Wan ... Fang Li

   Lys417 regulates the opening and closing of SARS-CoV-2 spike protein, allowing SARS-CoV-2 to maintain a delicate balance between infectiousness and evading host immune response.
2. 1. Evolutionary Biology
   2. Microbiology and Infectious Disease

   Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance

   Rebecca EK Mandt, Madeline R Luth ... Amanda K Lukens

   The mutational flexibility of the antimalarial target dihydroorotate dehydrogenase thwarts the use of collateral sensitivity as a strategy to suppress the evolution of resistance.
3. 1. Neuroscience

   Associative memory neurons of encoding multi-modal signals are recruited by neuroligin-3-mediated new synapse formation

   Yang Xu, Tian-liang Cui ... Jin-Hui Wang

   The coactivity of cortical neurons in associative learning recruits them as associative memory cells based on their synapse interconnections by neuroligin-3-mediated synapse formation, which endorses the first order and the second order of associative memory.
4. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting

   Ian R Outhwaite, Sukrit Singh ... Markus A Seeliger
5. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Avoiding false discoveries in single-cell RNA-seq by revisiting the first Alzheimer’s disease dataset

   Alan E Murphy, Nurun Fancy, Nathan Skene

   Reanalysis reveals the impact of quality control and differential analysis methods on the discovery of disease-associated genes on the first Alzheimer's disease single-nucleus RNA-seq dataset.
6. 1. Neuroscience

   Network-level changes in the brain underlie fear memory strength

   Josue Haubrich, Karim Nader

   Fear memory intensity modulates brain connectivity patterns, with stronger memories causing a pronounced reduction in interregional coordinated activity and isolation of the amygdala from other key regions.
7. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Indole produced during dysbiosis mediates host–microorganism chemical communication

   Rui-Qiu Yang, Yong-Hong Chen ... Cheng-Gang Zou

   In C. elegans, neuronic TRPA-1 senses bacterial accumulation by detecting indole production to up-regulate lysozyme genes via FOXO/DAF-16 in the intestine, thereby delaying microbial dysbiosis.
8. 1. Cell Biology
   2. Medicine

   Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

   Thao DV Le, Dianxin Liu ... Julio E Ayala

   The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
9. 1. Epidemiology and Global Health
   2. Medicine

   Association between bisphosphonate use and COVID-19 related outcomes

   Jeffrey Thompson, Yidi Wang ... Ulrich H von Andrian

   A claims-based retrospective cohort study shows that patients who used bisphosphonates between 01/01/2019 and 02/29/2020 had dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations during the initial surge of the COVID-19 pandemic in the US.
10. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions

    Luka Jarc, Manuj Bandral ... Anthony Gavalas