• The ins and outs of breathing

    Subpopulations of neurons in the pre-Bötzinger complex coordinate breathing with a range of physiological behaviors.

    Mariana R Melo, Alexander D Wykes ... Andrew M Allen
    Research Article Updated
  • How V. cholerae senses bile

    A complex called ToxRS is central to the mechanism by which bile acids cause Vibrio cholerae to become virulent.

    Nina Gubensäk, Theo Sagmeister ... Tea Pavkov-Keller
    Research Article Updated
  • Memory and multiple sclerosis

    A new approach to measuring visual working memory has revealed fresh insights into the origins of memory deficit in multiple sclerosis. (Photo: Pouria Motaghi CC-BY)

    Ali Motahharynia, Ahmad Pourmohammadi ... Mehdi Sanayei
    Research Article

Latest research

    1. Microbiology and Infectious Disease

    Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

    Qibin Geng, Yushun Wan ... Fang Li
    Lys417 regulates the opening and closing of SARS-CoV-2 spike protein, allowing SARS-CoV-2 to maintain a delicate balance between infectiousness and evading host immune response.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance

    Rebecca EK Mandt, Madeline R Luth ... Amanda K Lukens
    The mutational flexibility of the antimalarial target dihydroorotate dehydrogenase thwarts the use of collateral sensitivity as a strategy to suppress the evolution of resistance.
    1. Neuroscience

    Associative memory neurons of encoding multi-modal signals are recruited by neuroligin-3-mediated new synapse formation

    Yang Xu, Tian-liang Cui ... Jin-Hui Wang
    The coactivity of cortical neurons in associative learning recruits them as associative memory cells based on their synapse interconnections by neuroligin-3-mediated synapse formation, which endorses the first order and the second order of associative memory.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Avoiding false discoveries in single-cell RNA-seq by revisiting the first Alzheimer’s disease dataset

    Alan E Murphy, Nurun Fancy, Nathan Skene
    Reanalysis reveals the impact of quality control and differential analysis methods on the discovery of disease-associated genes on the first Alzheimer's disease single-nucleus RNA-seq dataset.
    1. Neuroscience

    Network-level changes in the brain underlie fear memory strength

    Josue Haubrich, Karim Nader
    Fear memory intensity modulates brain connectivity patterns, with stronger memories causing a pronounced reduction in interregional coordinated activity and isolation of the amygdala from other key regions.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Indole produced during dysbiosis mediates host–microorganism chemical communication

    Rui-Qiu Yang, Yong-Hong Chen ... Cheng-Gang Zou
    In C. elegans, neuronic TRPA-1 senses bacterial accumulation by detecting indole production to up-regulate lysozyme genes via FOXO/DAF-16 in the intestine, thereby delaying microbial dysbiosis.
    1. Cell Biology
    2. Medicine

    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

    Thao DV Le, Dianxin Liu ... Julio E Ayala
    The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
    1. Epidemiology and Global Health
    2. Medicine

    Association between bisphosphonate use and COVID-19 related outcomes

    Jeffrey Thompson, Yidi Wang ... Ulrich H von Andrian
    A claims-based retrospective cohort study shows that patients who used bisphosphonates between 01/01/2019 and 02/29/2020 had dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations during the initial surge of the COVID-19 pandemic in the US.