• ERK3 in control

    The kinase ERK3 influences the motility of tumor cells by controlling a previously unknown regulatory pathway.

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    Research Advance Updated
  • Seeing MHC activation in vivo

    MHC reporter mice can be used to analyse inflammation and neurodegeneration, and to study diseases such as multiple sclerosis.

    Em P Harrington, Riley B Catenacci ... Peter A Calabresi
    Tools and Resources Updated
  • Update on eLife’s new model

    In the first three months, we have seen consistent submissions and positive feedback from authors.

    Inside eLife

Latest research

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Mouse B2 SINE elements function as IFN-inducible enhancers

    Isabella Horton, Conor J Kelly ... Edward B Chuong
    An epigenomic analysis in mouse macrophages reveals that a highly abundant transposable element exhibits activity as an immune inducible regulatory element.
    1. Neuroscience

    Chronic exposure to odors at naturally occurring concentrations triggers limited plasticity in early stages of Drosophila olfactory processing

    Zhannetta V Gugel, Elizabeth G Maurais, Elizabeth J Hong
    Chronic stimulation with odors at naturally occurring concentrations only mildly impacts early stages of olfactory processing, suggesting a need to re-interpret prevailing models of how chronic odor exposure affects olfactory function.
    1. Medicine
    2. Neuroscience

    Oxytocin administration enhances pleasantness and neural responses to gentle stroking but not moderate pressure social touch by increasing peripheral concentrations

    Yuanshu Chen, Haochen Zou ... Keith M Kendrick
    A randomized placebo-controlled trial with behavioral, neuroimaging, and physiological measures reveals that oxytocin treatment facilitates pleasure and brain reward responses only to gentle stroking social touch by increasing peripheral blood concentrations.
    1. Immunology and Inflammation

    Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

    Pedro P Cunha, Eleanor Minogue ... Randall S Johnson
    Oxygen levels at the time of T cell activation are major determinants of function, even when T cells are subsequently expanded in high levels of oxygen.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

    Kanishk Jain, Matthew R Marunde ... Brian D Strahl
    MLL1-mediated H3K4 methylation is directly enhanced by cis-tail H3 acetylation, as shown through both in vitro and in vivo experiments.
    Short Report Updated
    Formats available:
    • HTML
    • PDF
    1. Cell Biology

    Replisome loading reduces chromatin motion independent of DNA synthesis

    Maruthi K. Pabba, Christian Ritter ... M. Cristina Cardoso
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Light inducible protein degradation in E. coli with LOVtag

    Nathan Tague, Cristian Coriano-Ortiz ... Mary J. Dunlop