Latest research

1. 1. Immunology and Inflammation

   Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells

   Anders Laustsen et al.

   Probing of various culture conditions leads to fundamental advances in ex vivo production of plasmacytoid dendritic cells for use in immunotherapy.
2. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

   Jinrui Dong et al.

   IL6ST (gp130) binding proteins, such as HyperIL6, promote liver regrowth in a STAT3-indpependent manner through competitive inhibition of anti-regenerative IL11 signaling.
3. 1. Medicine

   Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical

   Elisabeth Gludovacz et al.

   Because heparin-binding motif mutations of human diamine oxidase (hDAO) block cellular uptake and strongly decrease clearance in vivo, modified recombinant hDAO might be a good candidate for the treatment of symptoms induced by excessive endogenous histamine release.
4. 1. Evolutionary Biology
   2. Physics of Living Systems

   A framework for studying behavioral evolution by reconstructing ancestral repertoires

   Damián G Hernández et al.

   The behavioral repertoires from six species of flies are measured, and a statistical approach is developed to predict co-evolving behaviors, providing a potential framework for exploring behavioral evolution.
5. 1. Developmental Biology
   2. Neuroscience

   The development of active binocular vision under normal and alternate rearing conditions

   Lukas Klimmasch et al.

   A new computational model explains how alternate rearing conditions affect the development of binocular vision.
6. 1. Neuroscience

   The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

   Casey Paquola et al.

   The BigBrainWarp toolbox facilitates integration of 3D human brain histology with neuroimaging, helping neuroscientists to utilise cytoarchitectural information in conjunction with in vivo imaging.
7. 1. Neuroscience

   Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain

   Gabriella R Sterne et al.

   A split-GAL4 collection provides precise genetic targeting of 138 neuronal cell types in the subesophageal zone of adult Drosophila melanogaster.
8. 1. Cell Biology
   2. Developmental Biology

   Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT

   Spencer R Katz et al.

   Melanin staining for micro-CT imaging, using a novel application of ionic silver deposition, enables qualitative and quantitative 3D analysis of zebrafish pigmentation and reveals subtle phenotypes missed by light microscopy.
9. 1. Evolutionary Biology
   2. Genetics and Genomics

   Local adaptation and archaic introgression shape global diversity at human structural variant loci

   Stephanie M Yan et al.
10. 1. Stem Cells and Regenerative Medicine

    Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells

    Diptiman Chanda et al.

    Lung stem cell niche aging is associated with altered bioenergetics, metabolic dysfunction, and senescence of mesenchymal stromal cells that restricts 3D organoid, or alveolosphere formation, potentially accounting for reduced regenerative capacity with aging.