• ERK3 in control

    The kinase ERK3 influences the motility of tumor cells by controlling a previously unknown regulatory pathway.

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    Research Advance Updated
  • Seeing MHC activation in vivo

    MHC reporter mice can be used to analyse inflammation and neurodegeneration, and to study diseases such as multiple sclerosis.

    Em P Harrington, Riley B Catenacci ... Peter A Calabresi
    Tools and Resources Updated
  • Update on eLife’s new model

    In the first three months, we have seen consistent submissions and positive feedback from authors.

    Inside eLife

Latest research

    1. Epidemiology and Global Health

    Predictive performance of multi-model ensemble forecasts of COVID-19 across European nations

    Katharine Sherratt, Hugo Gruson ... Sebastian Funk
    A large collaborative project combined many different researchers' forecasts of COVID-19 across Europe, making predictions used in policy more reliable.
    1. Neuroscience

    Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex

    Lindsay Collins, John Francis ... David A McCormick
    Cortical cholinergic and noradrenergic signaling contains a strong low-frequency component that is distributed across the mouse cortex and is related to the behavioral state of the animal.
    1. Computational and Systems Biology

    Shared enhancer gene regulatory networks between wound and oncogenic programs

    Swann Floc'hlay, Ramya Balaji ... Stein Aerts
    Single-cell multiomics reveals the gene regulatory networks and enhancer logic underlying two distinct wound response cell states in the Drosophila wing imaginal disc and finds similarities with cell states observed in the Ras-scrib tumor model.
    1. Neuroscience

    Early language exposure affects neural mechanisms of semantic representations

    Xiaosha Wang, Bijun Wang, Yanchao Bi
    Impoverished access to natural human language during early childhood reduces semantic structure encoding in the left dorsal anterior temporal lobe, which provides positive evidence for the role of language in forming specific neural semantic representations in the human brain.
    1. Neuroscience

    Two conserved vocal central pattern generators broadly tuned for fast and slow rates generate species-specific vocalizations in Xenopus clawed frogs

    Ayako Yamaguchi, Manon Peltier
    Although courtship vocalizations are unique to each species, the basic architecture of the neural circuitries underlying this behavior is conserved among closely related species of frogs, suggesting behavior can diverge while utilizing the homologous neural network inherited through evolutionary lineage.
    1. Neuroscience

    Development of frequency tuning shaped by spatial cue reliability in the barn owl’s auditory midbrain

    Keanu Shadron, José Luis Peña
    The juvenile barn owl displays wide heterogeneity in tuning properties in the auditory midbrain, which is shaped during development to match the pattern of sensory statistics experienced in early life and maintained into adulthood.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading

    Hayley Porter, Yang Li ... Suzana Hadjur
    STAG proteins function independently of core cohesin at R-loops to facilitate cohesin loading.