• ERK3 in control

    The kinase ERK3 influences the motility of tumor cells by controlling a previously unknown regulatory pathway.

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    Research Advance Updated
  • Ultrafast cortical oscillations

    Optogenetic activation of thalamocortical axons produces ultrafast oscillations in cortical layer 4, along with responses in interneurons and excitatory cells.

    Hang Hu, Rachel E Hostetler, Ariel Agmon
    Research Article Updated
  • Update on eLife’s new model

    In the first three months, we have seen consistent submissions and positive feedback from authors.

    Inside eLife

Latest research

    1. Developmental Biology
    2. Computational and Systems Biology

    Precise temporal control of neuroblast migration through combined regulation and feedback of a Wnt receptor

    Erik S Schild, Shivam Gupta ... Hendrik C Korswagen
    Robust temporal regulation of a developmental decision in migrating Caenorhabditis elegans neuroblasts is mediated through a strategy that combines transcriptional activation and feedback of a timekeeper gene.
    1. Cell Biology

    Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart

    Brett C Baggett, Kevin R Murphy ... Gideon Koren
    Ex vivo, in vitro, and computational modeling studies indicate a persistence of myofibroblast senescence in the infarct border zone with age which can disrupt conduction and promote arrhythmias via senescent myofibroblast-cardiomyocyte coupling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structural basis of the multi-step allosteric activation of Aurora B kinase

    Dario Segura-Peña, Oda Hovet ... Nikolina Sekulic
    An entropy switch controls the Aurora B autoactivation process through two distinct kinetic steps of phosphorylation.
    1. Genetics and Genomics
    2. Neuroscience

    Neural mechanisms of parasite-induced summiting behavior in ‘zombie’ Drosophila

    Carolyn Elya, Danylo Lavrentovich ... Benjamin de Bivort
    In zombie fruit flies, Entomophthora muscae-elicited summiting behavior is mediated by blood-borne factors and the host circadian-neurosecretory network.
    1. Neuroscience

    Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours

    Flavia Venetucci Gouveia, Jurgen Germann ... Clement Hamani
    Integrated imaging analysis of a large multi-center dataset showed that treatment of refractory aggressive behavior with hypothalamic deep brain stimulation is highly effective with specific clinical and neuroimaging features associated with treatment success.
    1. Stem Cells and Regenerative Medicine

    Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity

    Claudia Dominici, Oscar D Villarreal ... Stéphane Richard
    Inhibition of type I PRMTs increases the proliferation capabilities of MuSCs with altered cellular metabolism, while maintaining their stem-like properties such as self-renewal and engraftment potential.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Neural circuit-wide analysis of changes to gene expression during deafening-induced birdsong destabilization

    Bradley M Colquitt, Kelly Li ... Michael S Brainard
    Large-scale gene expression analysis of the songbird brain identifies the molecular and cellular features of vocal motor circuits that are altered by the loss of hearing.
    1. Neuroscience

    The impact of task context on predicting finger movements in a brain-machine interface

    Matthew J Mender, Samuel R Nason-Tomaszewski ... Cynthia A Chestek
    1. Cell Biology

    Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions

    Florian Geisler, Sanne Remmelzwaal ... Rudolf E Leube