Axon growth in organoids

Latest research

1. 1. Developmental Biology
   2. Computational and Systems Biology

   Precise temporal control of neuroblast migration through combined regulation and feedback of a Wnt receptor

   Erik S Schild, Shivam Gupta ... Hendrik C Korswagen

   Robust temporal regulation of a developmental decision in migrating Caenorhabditis elegans neuroblasts is mediated through a strategy that combines transcriptional activation and feedback of a timekeeper gene.
2. 1. Cell Biology

   Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart

   Brett C Baggett, Kevin R Murphy ... Gideon Koren

   Ex vivo, in vitro, and computational modeling studies indicate a persistence of myofibroblast senescence in the infarct border zone with age which can disrupt conduction and promote arrhythmias via senescent myofibroblast-cardiomyocyte coupling.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The structural basis of the multi-step allosteric activation of Aurora B kinase

   Dario Segura-Peña, Oda Hovet ... Nikolina Sekulic

   An entropy switch controls the Aurora B autoactivation process through two distinct kinetic steps of phosphorylation.
4. 1. Genetics and Genomics
   2. Neuroscience

   Neural mechanisms of parasite-induced summiting behavior in ‘zombie’ Drosophila

   Carolyn Elya, Danylo Lavrentovich ... Benjamin de Bivort

   In zombie fruit flies, Entomophthora muscae-elicited summiting behavior is mediated by blood-borne factors and the host circadian-neurosecretory network.
5. 1. Neuroscience

   Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours

   Flavia Venetucci Gouveia, Jurgen Germann ... Clement Hamani

   Integrated imaging analysis of a large multi-center dataset showed that treatment of refractory aggressive behavior with hypothalamic deep brain stimulation is highly effective with specific clinical and neuroimaging features associated with treatment success.
6. 1. Stem Cells and Regenerative Medicine

   Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity

   Claudia Dominici, Oscar D Villarreal ... Stéphane Richard

   Inhibition of type I PRMTs increases the proliferation capabilities of MuSCs with altered cellular metabolism, while maintaining their stem-like properties such as self-renewal and engraftment potential.
7. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Neural circuit-wide analysis of changes to gene expression during deafening-induced birdsong destabilization

   Bradley M Colquitt, Kelly Li ... Michael S Brainard

   Large-scale gene expression analysis of the songbird brain identifies the molecular and cellular features of vocal motor circuits that are altered by the loss of hearing.
8. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation

   Francisco Xavier Galdos, Carissa Lee ... Sean Wu
9. 1. Neuroscience

   The impact of task context on predicting finger movements in a brain-machine interface

   Matthew J Mender, Samuel R Nason-Tomaszewski ... Cynthia A Chestek
10. 1. Cell Biology

    Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions

    Florian Geisler, Sanne Remmelzwaal ... Rudolf E Leube