Latest research

1. 1. Cell Biology

   Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity

   Mario Ruiz et al.

   Silencing the acyl-coA synthethase ACSL1 protects against saturated fat lipotoxicity by preventing the degradation of polyunsaturated fatty acids, allowing them to be incorporated into phospholipids and improves membrane fluidity.
2. 1. Neuroscience
   2. Physics of Living Systems

   Replay as wavefronts and theta sequences as bump oscillations in a grid cell attractor network

   Louis Kang, Michael R DeWeese

   An experimentally supported model of grid cells naturally enables them to participate in firing sequences that encode rapid trajectories in space.
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

   Chung Park, John H Kehrl

   Intravital imaging with HIV-1 viral-like particle in mouse model reveals a mechanism for HIV-1 uptake by subcapsular sinus macrophages that facilitates HIV-1 spreading tofollicular dendritic and B cells.
4. 1. Evolutionary Biology
   2. Genetics and Genomics

   Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome

   Andrew B Morgenthaler et al.
5. 1. Cell Biology
   2. Immunology and Inflammation

   B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments

   Sophie Isabel Roper et al.
6. 1. Neuroscience

   Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity

   Joana B Pereira et al.
7. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation during early hypoxia

   Fransky Hantelys et al.
8. 1. Neuroscience

   Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity

   Vanessa Plantier et al.
9. 1. Genetics and Genomics
   2. Neuroscience

   Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation

   Ryoji Amamoto et al.

   Probe-Seq is a cell type specific bulk RNA sequencing method that can be applied to a wide-ranging tissue types from both vertebrates and invertebrates without genetic labeling.
10. 1. Developmental Biology
    2. Neuroscience

    Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis

    Youngsik Woo et al.