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Highlights

  • Enhancing the Cre-loxP system

    Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo.

    Mengyang Shi, Jie Li ... Bin Zhou
    Reviewed Preprint Updated

  • Cell mechanics and metastasis

    The discovery of a pro-invasive mechanotransduction pathway driven by cell crowding suggests that an ion channel called TRPV4 may be a promising therapeutic target for inhibiting metastasis.

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
    Reviewed Preprint Updated

  • Social behaviors in mice

    A cell atlas for the preoptic area of the brain could be used to investigate how neuronal traits may be evolving to give rise to innate differences in social behavior across species.

    Jenny Chen, Phoebe R Richardson ... Hopi E Hoekstra
    Reviewed Preprint Updated

Latest research

    1. Developmental Biology

    Opposing roles for Bmp signalling during the development of electrosensory lateral line organs

    Alexander S Campbell, Martin Minařík ... Clare VH Baker
    In sturgeon, fewer electrosensory organs form after targeting Bmp5 for CRISPR/Cas9-mediated mutagenesis, whereas more form after chemically blocking all Bmp signalling shortly before their primordia emerge, suggesting that Bmp signalling has opposing effects during electrosensory organ development.
    1. Immunology and Inflammation

    MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles

    Linsey JF Peters, Leonida Rakateli ... Emiel PC van der Vorst
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice

    Carlos A Sánchez-León, Guillermo Sánchez-Garrido Campos ... Javier Márquez-Ruiz
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

    Kawaguchi Shinichi, Xu Xin ... Kai Toshie
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology

    Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum

    Lin Wei, Hai-Yan Cao ... Fuchuan Li
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Genetics and Genomics

    IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

    Mengjia Li, Hengchao Zhang ... Lixiang Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Re-focusing visual working memory during expected and unexpected memory tests

    Sisi Wang, Freek van Ede
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Plant Biology

    Molecular architecture of thylakoid membranes within intact spinach chloroplasts

    Wojciech Wietrzynski, Lorenz Lamm ... Benjamin D Engel
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Movie reconstruction from mouse visual cortex activity

    Joel Bauer, Troy W Margrie, Claudia Clopath
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    CRISPR-Edited DPSCs, Constitutively Expressing BDNF Enhance Dentin Regeneration in Injured Teeth

    Ji Hyun Kim, Muhammad Irfan ... Seung Chung
    Not revised
    Reviewed Preprint v1
    • Useful
    • Inadequate
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Magazine

  1. Science Under Threat in the United States: Feeling abandoned but energized

    Vaughn S Cooper

  2. Science Under Threat in the United States: How scientists and institutions should respond

    Ran Blekhman

  3. Science Under Threat in the United States: The NIH is a sound investment for the US taxpayer

    Nicholas W Gilpin
    1. Neuroscience

    Hippocampus: Mapping out overlapping connectivity patterns

    Myrthe Faber, Koen V Haak
    1. Cell Biology
    2. Developmental Biology

    Ovarian Biology: Revisiting the rete ovarii

    Yan Zhang, Hua Zhang
    1. Microbiology and Infectious Disease

    Viruses: How herpes is assembled

    Dawid S Zyla
    1. Neuroscience

    Metabolism: Insulin control in fruit flies

    Omowumi Kayode
  8. See more Magazine articles

Research categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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