Endemic Rift Valley fever virus circulation in The Gambia is driven by seasonal cattle movements and eco-region differences, highlighting livestock mobility as a key target for effective control strategies.
The genetic network of BTB zinc finger transcription factors and Eip93F is crucial for Kenyon cell identity regulation and neuronal function acquisition in the construction of Drosophila mushroom bodies.
Preethi Somasundaram, Madeline M Farley ... Trent A Watkins
A secondary stress signaling pathway in the response to optic axon injury is an unexpectedly strong contributor to both neurodegeneration and axon regenerative potential.
Shirley Mark, Philipp Schwartenbeck ... Timothy E Behrens
A novel fMRI method reveals that humans generalize task structure across non-aligned state spaces, showing entorhinal representations support flexible knowledge transfer.
Lauri Nurminen, Maryam Bijanzadeh, Alessandra Angelucci
The trial-to-trial variability of neuronal responses and the correlated response variability among neurons are modulated by visual stimulus size in a manner that depends on cortical layer, suggesting multiple circuits and mechanisms as the source of variability.
Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson
Design and integration of various biomolecular sensors for over-activated rat sarcoma (RAS) created synthetic gene circuits that distinguish mutant versus wild-type signaling and express a therapeutic protein to kill RAS-driven cancer cells.
Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenetic-like gene control without photoreceptors.
Saccades selectively disrupt spatial but not colour memory, and while transsaccadic updating remains resilient to ageing and neurodegeneration, individual drawing deficits arise from impaired initial encoding and memory decay.
A multivariate analysis of electroencephalography activity reveals super-additive enhancements to the neural encoding of audiovisual stimuli, providing new insights into how the brain integrates multisensory information to optimise spatial localisation.
Maximilian C Pöverlein, Alexander Jussupow ... Ville RI Kaila
Respiratory supercomplex formation relieves molecular strain of mitochondrial membranes and reshapes global protein motions, linking membrane reorganization to respiratory function.
During the acquisition of correct rejection response, rankings of functional connection separated for cortical and subcortical regions, which is predictive of the peak timing of visual information encoding across the network.
High-throughput measurement of neutralization titers using a new sequencing-based assay can help explain which seasonal influenza strains spread in the human population.
Camille Elleaume, Bruno Hebling Vieira ... Nicolas Langer
Systematic analyses show that normative model performance strongly depends on sample size and covariate distributions, larger samples yield more stable fits, while misaligned covariates introduce systematic distortions in predictions.
Giuseppina R Briola, Mohammad Tehseen ... Alfredo De Biasio
Human CTF18–RFC employs a unique structural stabilization mechanism to optimize PCNA loading and stimulate DNA synthesis by the leading-strand polymerase.
Vitaly Ryu, Anisa Azatovna Gumerova ... Mone Zaidi
The compendium of oxytocin and its receptor in the brain could provide further insights into the peripheral and central effects of oxytocin in health and disease.
Gender differences in submission behavior, driven by self-perceptions of novelty and peer discouragement, limit women’s representation in high-impact journals and, in turn, their scientific visibility and career advancement.
The pattern of reaching biases is stable across contexts and can be attributed to a misalignment between eye-centric and body-centric representations of position.
Eric R Wengert, Sophie R Liebergall ... Ethan M Goldberg
Brain slice electrophysiology, immunohistochemistry, and in vivo two-photon calcium imaging identify circuit dysfunction and epilepsy mechanism in a Kcnc1-A421V/+ mouse model of developmental and epileptic encephalopathy.
Francesca S Wong, Simon Killcross ... Nathan M Holmes
The basolateral amygdala complex and perirhinal cortex function like the focal and peripheral states of attention described by classic associative learning theories.
Cyp17a2 enhances antiviral responses in male zebrafish by stabilizing STING through TRIM11-mediated K33-linked polyubiquitination, boosting IFN production.
Intrinsic cell cycle progression governs developmental time in neural stem cells by regulating temporal gene transitions that generate neural diversity.
Counterconditioning improved safety memory retrieval over regular extinction, showing a shift away from vmPFC towards nucleus accumbens, and may thereby be a promising new treatment option.
Microfossils reported from Archaean BIFs most likely were liposome-like protocells, which had evolved intracellular mechanisms for energy conservation but not for regulating cell morphology and replication.
Jean-Mathieu Desveaux, Eric Faudry ... Pascal Poignard
Human antibodies isolated from cystic fibrosis patients against PscF and PcrV of the Pseudomonas aeruginosa Type 3 Secretion System reveal that anti-PcrV antibodies inhibit secretion through distinct mechanisms.
Severine LD Toussaint, Dionisios Youlatos, John A Nyakatura
Vertical locomotion in arboreal mammals is shaped by a complex interplay of body mass, limb proportions, grasping abilities, and head mass, and primates use distinct upright postures during descents.
A detailed annotation of anatomical brain structures (some novel) of the spider Uloborus diversus is provided based on a three-dimensional immunostain atlas.
Adam A Atanas, Alicia Kun-Yang Lu ... Steven W Flavell
New machine vision tools are used to align densely packed cells recorded from live, deforming tissues and automatically annotate the identities of the recorded cell types.
A threefold hippocampal code across conceptual directions, phase-locked to entorhinal grid activity, reveals a periodic mechanism through which entorhinal grids structure hippocampal vector representations.
Volume EM and connectome reconstruction of the apical organ of a ctenophore combined with high-speed imaging reveals a neuronal coordination of balancer cilia in the gravisensory organ.
Maryanne Derkaloustian, Pushpita Bhattacharyya ... Charles B Dhong
To study fine touch, selecting samples based on how many mechanical instabilities they can form is more predictive than using the friction coefficient, which has been the default choice.
Conditional genetics and single-embryo RNA-seq show that SETDB1 extinguishes the transient, retroelement-driven transcriptional programs of the totipotent two-cell state to facilitate the exit from totipotency and ensure preimplantation development.
The adjoint propagation framework enables the concurrent flow of signals and errors, providing a biologically and physically plausible learning mechanism.
Premature termination of transcription influences ribosomal RNA output and RNA polymerase I drug sensitivity, revealing a mechanism of resistance to transcription-targeting chemotherapy.
The RNA-binding protein BICC1 can act as a genetic disease modifier for kidney cyst formation, potentially explaining the high variability of disease onset and severity in autosomal-dominant polycystic kidney disease patients.
A comprehensive single-cell atlas of AML uncovers regulatory networks and age-dependent molecular differences to advance the understanding of disease mechanisms and enable subtype-specific therapeutic strategies.
Hannu Lahtinen, Jaakko Kaprio ... Pekka Martikainen
Polygenic indices related to the best-established social, psychological, and behavioural mortality risk phenotypes had the strongest associations with mortality.
Jennifer C Fielder, Jinyu Shi ... Nikolaus Steinbeis
A novel behavioural task that measures and manipulates subjective control in humans reveals that experimentally heightened feelings of control buffer against the negative impact of subsequent stress.
Excitatory recurrent synapses in the upper pyramidal layer of the prefrontal cortex exhibit delayed short-term facilitation, despite very high vesicular fusion probability, through synaptotagmin 7-dependent overfilling of release sites.
Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational modifications, and aggregation state shape antibody specificity, thereby guiding selection and development of therapeutic antibodies in Alzheimer’s disease.
Three newly developed biosensors demonstrate that the C-terminal tail of α-tubulin does not freely extend from the microtubule surface as widely thought, but rather is inaccessible along most microtubules in cells.
Philémon Roussel, Mingyi Zhou ... Auguste Genovesio
Metabolic imaging of the Drosophila mushroom body reveals distinct profiles among Kenyon cell subtypes and detects a subtle learning-associated metabolic change.
Harrison A Grier, Sohrab Salimian, Matthew T Kaufman
Mouse primary motor and somatosensory cortices contain detailed information about the many time-varying arm and paw joint angles during reaching and grasping, implying a 'low-level' role in controlling these movements.
Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.
Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and survival.
A multidisciplinary approach demonstrates that glycolysis orchestrates fungal morphogenesis and virulence by regulating the de novo biosynthesis of sulfur-containing amino acids, thereby establishing a novel metabolic paradigm.
Small-molecule mitochondrial transcription factor A modulators stabilize mtDNA, preventing cytosolic escape and suppressing cGAS-STING interferon signaling, while improving bioenergetics and fibrosis markers in disease models.
Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.
Upregulated expression of transcription factors promoting cone identity in late-stage retinal progenitors drives development of the cone-dominant retina of 13-lined ground squirrels.
The IL-17–Ly6G⁺ granulocyte axis is a key driver and correlate of tuberculosis pathology and represents a potential target for improving vaccine-induced protection and therapeutic outcomes.
Even in a simple epithelial tissue that is exposed uniformly to X-ray irradiation, cells show marked differences in their transcriptional response based on their location and cell-cycle status.
Marie Baldenius, Steffen Kautzmann ... Christian Klämbt
In Drosophila larva, the Uninflatable protein helps to switch from FGF-receptor triggered glial growth to Notch triggered wrapping of peripheral axons.
Inhibiting PRMT1 and PRMT5 renders HR-proficient ovarian and breast cancers highly vulnerable to PARP inhibition by suppressing BRCAness and amplifying DNA-damage-driven innate immune signaling.
Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.
A flexible but automatic stimulus-response mapping mechanism complements forward model recalibration in walking adaptation, immediately accounting for perceived changes in the environment through perception altered by the same recalibration process.
Ozkan Aydemir, Jeffrey A Bailey ... TEDDY Study Group
HLA-DRA intronic haplotype associates with opposite effects on type 1 diabetes and celiac disease, refining genetic risk prediction and implicating complement genes C4A and C4B in divergent autoimmune pathways.
The acquisition and expression of Pavlovian conditioned responding are shown to be lawfully related to objectively specifiable temporal properties of the events the animal is learning about.
Mixture discrimination training induces durable, transferable olfactory learning, highlighting mixture configural odor quality as a distinct attribute supported by different plasticity mechanisms than chirality or concentration and offering a promising leverage point for olfactory rehabilitation.
