Microscopy versus malaria

Latest research

1. 1. Cell Biology

   Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

   Xiang Wang, Vitaliy V Bondar ... Anastasia G Henry

   Rab12 was identified as a key modulator of LRRK2-dependent Rab phosphorylation that mediates the recruitment of LRRK2 to lysosomes in response to damage.
2. 1. Cell Biology

   Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

   Herschel S Dhekne, Francesca Tonelli ... Suzanne R Pfeffer

   Activating mutations in the leucine-rich repeat kinase 2 cause Parkinson’s disease, and an unbiased genome-wide screen revealed an unexpected, specific role for Rab12 in activating this kinase directly for Rab GTPase phosphorylation.
3. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

   Nadja S Katheder, Kristen C Browder ... Heinrich Jasper
4. 1. Computational and Systems Biology

   Homeostasis, injury and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt

   Louis Gall, Carrie Duckworth ... Carmen Pin
5. 1. Biochemistry and Chemical Biology
   2. Evolutionary Biology

   Evolution towards simplicity in bacterial small heat shock protein system

   Piotr Karaś, Klaudia Kochanowicz ... Krzysztof Liberek

   Phylogenetic and biochemical analysis reveals crucial role of two substitutions in the α–crystallin domain for development of new functionality of IbpA chaperone after the loss of paralogous IbpB in Erwiniaceae.
6. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Enterobacterales plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches in Oxfordshire, UK

   William Matlock, Samuel Lipworth ... REHAB Consortium

   A geographically and temporally restricted genomic surveillance study concludes that Enterobacterales plasmid dissemination between human and non-human niches might be occurring at greater rates than previously estimated.
7. 1. Neuroscience

   ACC neural ensemble dynamics are structured by strategy prevalence

   Mikhail Proskurin, Maxim Manakov, Alla Karpova

   Anterior Cingulate Cortex displays robust tracking during strategy execution of a summary statistic for that strategy in recent behavioral history, suggesting a role for this brain region in estimating which actions promote the occurrence of events in the environment.
8. 1. Cell Biology

   Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

   Ling-Yun Zhou, Chen-Xi Jin ... Hao Wu

   In hair cells, the development and maintenance of the F-actin-enriched stereocilia and cuticular plates are differentially regulated by transcription factors SRF and MRTFB, and SRF–CNN2 is required for modulating actin dynamics of the stereocilia and cuticular plate.
9. 1. Neuroscience

   Microprism-based two-photon imaging of the mouse inferior colliculus reveals novel organizational principles of the auditory midbrain

   Baher A. Ibrahim, Yoshitaka Shinagawa ... Daniel A. Llano
10. 1. Cell Biology

    Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity

    Edward M. Germany, Nakajohn Thewasano ... Takuya Shiota