The activation of nucleation

Latest research

1. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

   Abhinay Ramaprasad, Paul-Christian Burda ... Michael J Blackman

   The malaria parasite uses an enzyme called GDPD to absorb choline, an important nutrient, from the bloodstream and this is essential for the parasite to survive inside the red blood cell.
2. 1. Medicine

   Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts

   Richard C Lauer, Marc Barry ... Wadih Arap

   PRUNE2/PCA3 axis dysregulation is an early, rather than late, event in prostate cancer tumorigenesis.
3. 1. Developmental Biology

   Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

   Florian Schueder, Pierre Mangeol ... Frank Schnorrer

   The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.
4. 1. Developmental Biology

   A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

   Vincent Loreau, Renate Rees ... Dirk Görlich

   A collection of 22 nanobodies against 11 different Drosophila sarcomeric protein epitopes was generated, validated in stainings and for some transgenic fly lines were generated to monitor the dynamics of the sarcomeric proteins in muscles in vivo.
5. 1. Cell Biology
   2. Neuroscience

   Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders

   Lydie Burglen, Evelien Van Hoeymissen ... Joris Vriens

   Newly identified gain-of-function variants indicate TRPM3 as the cause of a spectrum of autosomal dominant neurodevelopmental disorders with frequent cerebellar involvement in humans.
6. 1. Physics of Living Systems

   Geometric control of Myosin-II orientation during axis elongation

   Matthew F Lefebvre, Nikolas H Claussen ... Sebastian J Streichan
7. 1. Structural Biology and Molecular Biophysics

   State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels

   Yein Christina Park, Bharat Reddy ... José D Faraldo-Gómez
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Plasmodium infection disrupts the T follicular helper cell response to heterologous immunization

   Mary F Fontana, Erica Ollmann Saphire, Marion Pepper

   Flow cytometric analysis of antigen-specific B and T cell responses to heterologous immunization reveals intact dendritic cell function, but selective defects in germinal center formation, in mice with concurrent malaria.
9. 1. Cancer Biology
   2. Medicine

   International multicenter study comparing COVID-19 in patients with cancer to patients without cancer: impact of risk factors and treatment modalities on survivorship

   Issam I Raad, Ray Hachem ... Anne-Marie Chaftari
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility

    Fernanda M Bosada, Karel van Duijvenboden ... Vincent M Christoffels