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Latest research

    1. Computational and Systems Biology

    Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation

    Leonardo Vinicius Monteiro de Assis et al.
    High triiodothyronine levels lead to a broad rewiring of the liver transcriptome, which mostly occurs downstream of the liver clock machinery itself, thus suggesting that daytime critically affects thyroid hormone action in the liver.
    1. Genetics and Genomics

    Nomograms of human hippocampal volume shifted by polygenic scores

    Mohammed Janahi et al.
    Accounting for genetic information improved normative models of hippocampal volume in humans by accounting for change equivalent to around 3 years of normal loss for a person aged 65.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of a counter-defense mechanism in a virus constrains its host range

    Sriram Srikant et al.
    Bacteriophage can rapidly evolve resistance to anti-phage defense elements in bacteria by amplifying latent counter-defense genes, though this amplification comes at a cost of compensatory deletions that eliminate other counter-defense genes.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    BIRC6 modifies risk of invasive bacterial infection in Kenyan children

    James J Gilchrist et al.
    Defining the probability of bacterial disease among children with severe malaria allows the integration of bacteraemia and severe malaria genome-wide association study data, identifying a novel risk locus for invasive bacterial disease.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans

    Susanna Lemmelä et al.
    Elevated growth differentiation factor-15 (GDF15) levels do not appear to be a causal factor in body mass index (BMI) in humans but higher BMI does cause increases in GDF15.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    The unmitigated profile of COVID-19 infectiousness

    Ron Sender et al.
    In the absence of COVID-19 mitigation measures, SARS-CoV-2 remains infectious for longer than previously estimated.
    1. Neuroscience

    Prenatal development of neonatal vocalizations

    Darshana Z Narayanan et al.
    Vocal development in marmoset monkeys begins in utero.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

    Sobhika Agarwala et al.
    Multiple imaging modalities resolved the ultrastructure of single hematopoietic stem cells in their endogenous niche, allowing identification of dopamine beta-hydroxylase positive cells as a functional niche cell type.
    1. Developmental Biology

    Transgenic quails reveal dynamic TCF/β-catenin signaling during avian embryonic development

    Hila Barzilai-Tutsch et al.
    A novel avian transgenic line allows studying the function of Wnt signaling during embryonic development.
    1. Neuroscience

    Expansion and contraction of resource allocation in sensory bottlenecks

    Laura R Edmondson et al.
    A simple efficient coding model predicts complex trade-offs in resource allocation for sensory inputs with heterogeneous receptor densities and activation levels.