Latest research

1. 1. Cancer Biology

   TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth

   Sander AL Palit et al.

   A mechanistic link between TLE3 loss and glucocorticoid receptor-mediated androgen receptor inhibitor resistance supports the rationale to target GR during anti-hormonal treatment in castrate-resistant prostate cancer.
2. 1. Biochemistry and Chemical Biology

   The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers

   Purnima Klingauf-Nerurkar et al.

   The GTPase Nog1 orchestrates stalk assembly, peptidyl transferase centre maturation and polypeptide exit tunnel quality control.
3. 1. Cancer Biology
   2. Developmental Biology

   Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

   Alec K Gramann et al.

   The oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.
4. 1. Developmental Biology
   2. Neuroscience

   A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture

   Alfredo Llorca et al.

   The specification of a very small number of progenitor cells with competence to adapt their neurogenic output to different probabilistic rules underlies the generation of distinct cortical cytoarchitectures.
5. 1. Neuroscience

   Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation

   Alexandre Mahrach et al.
6. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Transcriptional adaptation in Caenorhabditis elegans

   Vahan Serobyan et al.

   Genes implicated in mutant mRNA decay and small RNA maturation and transport into the nucleus are required for transcriptional adaptation in C. elegans.
7. 1. Structural Biology and Molecular Biophysics

   The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

   Ahmad Abdelzaher Zaki Khalifa et al.
8. 1. Structural Biology and Molecular Biophysics

   Structure of the human BBSome core complex

   Björn Udo Klink et al.
9. 1. Cell Biology

   Kinesin Kif2C in regulation of DNA double strand break dynamics and repair

   Songli Zhu et al.
10. 1. Cell Biology
    2. Physics of Living Systems

    Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

    Matthew Akamatsu et al.