Latest research

1. 1. Microbiology and Infectious Disease

   Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

   Heiner Atze et al.

   Labeling with ¹³C and ¹⁵N in the absence of metabolic engineering enabled the exploration of peptidoglycan metabolism at a very fine level of detail based on kinetic characterization of isotopologues predicted to occur according to known recycling and biosynthesis pathways.
2. 1. Cell Biology
   2. Developmental Biology

   Androglobin, a chimeric mammalian globin, is required for male fertility

   Anna Keppner et al.

   Androglobin, a newly identified mammalian globin with a unique modular structure including a protease and calmodulin binding IQ domain within a circularly permuted globin domain, is implicated in murine spermatogenesis.
3. 1. Developmental Biology
   2. Evolutionary Biology

   An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates

   Alexandre P Thiery et al.

   The development of diverse tooth shapes among vertebrates, from sharks to mammals, is a highly conserved process, utilising a similar dental signalling centre for more than 400 million years.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Visualizing molecules of functional human profilin

   Morgan L Pimm et al.

   Fluorescently-tagged profilin-1 behaves similar to the tag-free protein in biochemical and cell-based assays.
5. 1. Neuroscience

   Long-term transverse imaging of the hippocampus with glass microperiscopes

   William T Redman et al.

   Two-photon imaging through glass microperiscopes allows imaging of the transverse plane of the hippocampus, including all major subfields, in awake behaving mice.
6. 1. Cancer Biology

   Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

   Laura M Sipe et al.
7. 1. Neuroscience

   Synaptic location is a determinant of the detrimental effects of α-Synuclein pathology to glutamatergic transmission in the basolateral amygdala

   Liqiang Chen et al.
8. 1. Ecology

   Life-history predicts global population responses to the weather in terrestrial mammals

   John Jackson et al.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2

   Brandon Wey-Hung Liauw et al.
10. 1. Microbiology and Infectious Disease

    Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite

    Pengge Qian et al.