August 2026

Cover articles

    1. Neuroscience

    Insights into synaptic dysfunction

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    1. Cancer Biology

    Mechanics of oncogenesis

    Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
    1. Ecology

    Body size and urban survival

    Corey T Callaghan, Diana E Bowler ... Thomas Merckx
    1. Developmental Biology
    2. Evolutionary Biology

    Re-evolving traits

    Angelly Vasquez-Correa, Johanna Arnet ... Ehab Abouheif

Highlights controls:

Research articles

    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Microscopic PhotoSelection (MiPS) of single cells in mother machine microfluidic devices

    Jessica James, Idris Kempf ... Harrison Steel
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    1. Ecology
    2. Evolutionary Biology

    Spatiotemporal patterns of genetic diversity in the world’s coral reefs

    Oliver Selmoni, Meredith C Schuman
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease
    2. Ecology

    Tracking West Nile virus dynamics using viral loads from trapped mosquitoes

    Punya Alahakoon, Ian Marchinton ... James A Hay
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Ecology

    Planetary-scale heterotrophic microbial community modeling assesses metabolic synergy and viral impacts

    Antoine Régimbeau, Funing Tian ... Damien Eveillard
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology

    SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells

    Noa Nashnaz, Dana Goldberg ... Dan Levy
    SETD6-mediated methylation of PPARγ establishes a positive feedback mechanism that enhances transcriptional activation and promotes hepatic lipid accumulation.
    1. Neuroscience

    Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation

    Sofie S Jacobsen, Allison B Morehouse ... Celia Kjaerby
    Very-low-frequency heart rate variability reflects locus coeruleus activity during sleep and predicts spindle-dependent memory consolidation across mice and humans.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Pre-Cambrian origin of envelope-carrying retrotransposons in metazoans

    Shashank Chary, Rippei Hayashi
    Envelope-carrying Ty3/gypsy LTR retrotransposons are ancient and widespread across animals, revealing deep evolutionary links between retroelements, viral fusogens, and retroviruses.
    1. Neuroscience

    Dynamic fMRI networks of human emotion

    Niels Janssen, Uriel KA Elvira ... Theo GM van Erp
    Time-resolved mapping of whole-brain functional MRI networks during human emotional experience reveals a dynamic systems-level organization that links temporal processing with large-scale functional brain architecture.
    1. Epidemiology and Global Health

    Understanding pain in women with polyendocrine metabolic ovarian syndrome: health risks and treatment effectiveness

    Tess Cherlin, Stephanie Mohammed ... Shefali Setia Verma
    Pain affects one in five women with PMOS, with pronounced racial disparities and meaningful reduction following targeted medical treatment.
    1. Genetics and Genomics

    Systematic cross-study assessment of RNA-Seq experimental workflows for plasma cell-free transcriptome profiling

    Cristina Tuñí-Domínguez, Giovanni Asole ... Julien Lagarde
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics

    Genomic variation and ancestry of Helicobacter pylori in the admixed population of Cabo Verde reveal host adaptation, limited host–pathogen ancestry concordance, and signatures of trans-Atlantic slave trade migrations

    Timothy Archampong, Yi Ling Tam ... Sandra Beleza
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Multi-timescale dynamics organize descending pain modulation

    Carl Ashworth, Melissa Martenson ... Flavia Mancini
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Ecology

    Monkey hear, monkey do what? An application of Automated Behavioural Response systems for hypothesis testing in the world’s smallest monkey

    Larissa Barker, Sarah Papworth
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Prenatal Alcohol Exposure Disrupts γ-Secretase Activity and Impairs Learning and Memory in Wild-Type and 3xTg-AD Mice

    Paola Montenegro, Rachel Kim ... Hermes Yeh
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Evolution imposes an inductive bias that alters and accelerates learning dynamics

    Benjamin Midler, Alejandro Pan Vazquez
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology
    2. Computational and Systems Biology

    Systematic analysis of network-driven adaptive resistance to CDK4/6 and oestrogen receptor inhibition using meta-dynamic network modelling

    Anthony Hart, Sung-Young Shin, Lan K Nguyen
    Meta Dynamic Network analysis can identify the capacity of a network to facilitate adaptive drug resistance and the respective underlying mechanistic causes.
    1. Cell Biology

    Zasp52’s differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc

    Nikolai Ho, Frieder Schöck
    The Z-disc of muscle sarcomeres is a solid aggregate stabilized by the intrinsically disordered region of the Alp/Enigma family protein Zasp52.
    1. Ecology
    2. Evolutionary Biology

    Evolution of sideways locomotion in crabs

    Junya Taniguchi, Tsubasa Inoue ... Yuuki Kawabata
    Sideways locomotion in true crabs likely originated once from a forward-moving ancestor, providing insight into how behavioral innovations shape evolutionary diversification.
    1. Cell Biology

    Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

    Jessica Tittelmeier, Carl Alexander Sandhof ... Carmen Nussbaum-Krammer
    Restoring endolysosomal membrane fluidity limits tau seed escape, seeded aggregation, and neuronal toxicity in cell and animal models.
    1. Biochemistry and Chemical Biology

    A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

    Daniel J Kelpsch, Liyun Zhang ... Steven A Farber
    An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.
    1. Neuroscience

    HSSM: A Widely Applicable Toolbox for Hierarchical Bayesian Neurocognitive Modeling

    Alexander Fengler, Yang Xu ... Michael J Frank
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Genetics and Genomics
    2. Evolutionary Biology

    Life-stage-specific specialities in the cell atlases of the Clytia hemisphaerica planula and medusa

    Anna Ferraioli, Julia Ramon Mateu ... Richard R Copley
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Perceiving animacy in ‘identical’ images

    Tal Boger, Chaz Firestone
    Visual anagrams, images whose interpretations change with orientation, isolate visual processing of animacy itself, beyond its lower-level correlates.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey

    Go Kasuya, Kaei Ryu ... Koichi Nakajo
    A lamprey KCNE protein provides insight into the early evolution of vertebrate potassium-channel regulation.
    1. Structural Biology and Molecular Biophysics

    A membrane insertion code for intrinsically disordered proteins

    Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou
    A sequence-based method dubbed AroMIP predicts the membrane insertion propensities of aromatic-centered motifs, thereby advancing mechanistic understanding of membrane insertion and enriching the tools for studying intrinsically disordered protein (IDP)-membrane association.
    1. Neuroscience

    Adaptive behavior is guided by integrated representations of controlled and non-controlled information

    Bingfang Huang, Harrison Ritz, Jiefeng Jiang
    Controlled and non-controlled information are simultaneously encoded within an integrated representation in partially overlapping neural subspaces, and the strengths of both representations jointly predict performance.
    1. Neuroscience

    Top-down feedback in deep neural networks leads to functional differences during audiovisual integration

    Mashbayar Tugsbayar, Mingze Li ... Blake Richards
    Gain-modulating top-down feedback introduces behavioral differences between otherwise identical neural networks, particularly in a network with connectivity based on the human brain, which displays a flexible visual bias similar to that seen in humans.
    1. Evolutionary Biology

    Ancient pyroptotic machinery via GSDMA/B cleavage by LPS-activated caspase-1 in cartilaginous fish

    Xuxia Wei, Ru Zhuang ... Shaochun Yuan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    Terminal Schwann Cells Regulate Presynaptic Vesicle Homeostasis but Not Neuromuscular Junction Integrity in Mice

    Hyun Kim, Seon-Yong Kim ... Young-Yun Kong
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    A nanoscale atlas of extracellular vesicles and particles in Drosophila olfactory sensilla

    Pawel Vijayakumar, Kalyani Cauwenberghs ... Chih-Ying Su
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    The genetic architecture of dementia risk: how Alzheimer’s disease vulnerability converges on lipid metabolism and immune cell networks

    Evelina Husén, Zhuoran Cai ... Jan Mulder
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Stimulating neurogenesis of distinct retinal lineages in human retinal pigmented epithelium (RPE) with proneural transcription factors

    Lew Kaplan, Abigail L Green ... Thomas A Reh
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Multi-Task Batteries for Precision Functional Mapping

    Bassel Arafat, Caroline Nettekoven ... Jörn Diedrichsen
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Adolescent social isolation creates a latent vulnerability in maternal care with intergenerational social consequences, rescued by experienced mothers

    Jose Francis-Oliveira, Rinako Tanaka ... Minae Niwa
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Axially decoupled photo-stimulation and two photon readout (ADePT) for mapping functional connectivity of neural circuits

    Matthew Koh, Francesca Anselmi ... Dinu F Albeanu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Temporal constraints on the neural signatures of narrative processing

    Aline-Priscillia Messi, Abir Bhuyain, Liina Pylkkanen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Distance Mapping and Variable-Specific Geometry of Goal-Relevant Frames in the Retrosplenial Cortex

    Yumin Chen, Xinhang Wei ... Haibing Xu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Evolutionary Biology

    Super compensatory substitutions restore protein function and flatten fitness landscapes

    Wenhong Jiang, Hengchuang Yin ... Lucas B Carey
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Whole brain mapping of spinal-projecting neurons in larval zebrafish

    Martin Carbo-Tano, Kevin Fidelin ... Claire Wyart
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Computational and Systems Biology

    Protein generation with evolutionary diffusion: sequence is all you need

    Sarah Alamdari, Nitya Thakkar ... Kevin K Yang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    High basal autophagic activity in the brain revealed by systemic quantitative analysis using GFP-LC3-RFP mice

    Yuki Kanda, Tomoya Eguchi ... Noboru Mizushima
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Optimising the tilt increment for in situ cryo-electron tomography

    Maarten Willem Tuijtel, Tomáš Majtner ... Martin Beck
    For in situ cryo-electron tomography, smaller tilt increments yield better-aligned tilt-series and higher-quality tomograms, with a 3° increment resulting in optimal subtomogram averaging resolution.
    1. Cell Biology

    Mitochondrial-derived compartments buffer outer membrane protein load during acute mitochondrial adaptation

    Bo J Price, Sai Sangeetha Balasubramaniam, Adam L Hughes
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Cell cycle-coupled CK1δ turnover, autoinhibition, and activity

    Fidel E Serrano, Bianca Ruppert ... Michael Brunner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Distinct nanoscale organizations of mucins and trans-sialidases in Trypanosoma cruzi

    Gonzalo Escalante, Raquel Parada-Puig ... Fernando D Stefani
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    Ferroptosis is executed through caspase-5 cleavage of gasdermin E in ovarian cancer cells

    Mahmuda Akter, Lei Sun ... Shuang Huang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Macrodomain catalytic activity modulates Chikungunya virus dissemination and transmission potential in Aedes mosquitoes

    Eugenia S Bardossy, Lena Bergmann ... Maria-Carla Saleh
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Evolutionary Biology

    Measurement and comparison of acoustic space use in vocalizations of humans and close primate relatives

    Hans T Bilger, Michael J Ryan, Julia A Clarke
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Finely Alleviate Diabetes Mellitus via a Ca2+- CaMKKβ-AMPK pathway

    Jiaxuan Zhu, Zhaonan Pan ... Dan Li
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Inadequate
    1. Neuroscience

    Where you aim – not how you aim – affects implicit recalibration in visuomotor adaptation

    Yiyu Wang, Jordan A Taylor
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Pupil and Neural Dynamics Reveal Belief-Dependent Decision Making Under Ambiguity

    Yinuo Qin, Nuttida Rungratsameetaweemana ... Paul Sajda
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Ecology

    Crickets evade bats via olfaction beyond acoustic cues

    Yannan Li, Wenhao Zhang ... Aiqing Lin
    Olfactory bat avoidance in crickets uncovers an overlooked sensory axis in this classic system and a functional eavesdropping strategy across phylogenetically distant predator–prey interactions.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Genome-wide architecture of prolonged starvation adaptation in experimentally evolved Drosophila and comparative enrichment in human orthologs

    Gaurav Yadav, Prachi Mishra ... Dau Dayal Aggarwal
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics
    2. Ecology

    Eco-genomic analysis uncovers precision-conservation targets for the western Pacific’s southernmost salmonid

    Yi-Chien Lee, Zong-Yu Shen ... Sheng-Feng Shen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans

    Zenith D Rudich, Jiaxi Guan ... Jeremy M Van Raamsdonk
    Comparing gene expression across a panel of nine long-lived mutants in a single study reveals that these mutants utilize both common and unique genetic strategies to achieve long life.
    1. Neuroscience

    Neural computations in the foveal and peripheral visual fields during active search

    Jie Zhang, Xiaocang Zhu ... Huihui Zhou
    Foveal attentional processing coordinates with peripheral attention to dynamically shape global attention allocation and fixation behavior during active vision.
    1. Computational and Systems Biology

    Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females

    Hélène Vantomme, Valentin Quiniou ... David Klatzmann
    Sex-specific biases in thymic T cell receptor selection enrich female CD8 T cell repertoires for autoimmunity-associated self-antigens, helping explain women’s increased susceptibility to autoimmune diseases.
    1. Neuroscience

    Visuomotor mismatch EEG responses over occipital cortex of freely moving human subjects

    Magdalena Solyga, Marek Zelechowski, Georg B Keller
    Visuomotor mismatch events elicit robust human prediction error responses that exceed conventional oddball mismatch negativity, enabling translation of sensorimotor prediction mechanisms from mice to humans.
    1. Epidemiology and Global Health

    Heterogeneity of use, access, and retention of insecticide-treated nets: Implications for subnational tailoring to maximise malaria control

    Andrew C Glover, Hannah Koenker ... Thomas S Churcher
    While transmission intensity should still drive where insecticide-treated nets are prioritised, deprioritising areas where people are more likely to use nets may cause larger case resurgences than otherwise expected.
    1. Physics of Living Systems

    Viral commitment to infection depends on host metabolism

    Anastasios Marantos, Kim Sneppen ... Namiko Mitarai
    Energy-limited bacterial cells reduce phage adsorption, particularly for weakly binding viruses, revealing host physiology as a key factor in viral commitment to infection.
    1. Genetics and Genomics
    2. Neuroscience

    The Drosophila IR20a Integrates L-arginine and Salt Signals via Distinct Subunit Assemblies

    Bo Wang, Guangnan Qu ... Yan Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Chromosomes and Gene Expression

    Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets

    Peter Chovanec, Shiyang He, Yi Yin
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology

    Prophase Chromosomes Relocalization to Nuclear Periphery in NPP-3/NUP205 Depletion Protects Genome Stability

    Ling Jiang, Yu Chung Tse, Karen Wing Yee Yuen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics

    Jian Qiu, Martha A Bosch ... Martin J Kelly
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology

    A senescent-immune reserve niche model for incomplete lobular involution in the aging breast

    Jaida C Lue, Darren J Baker ... Derek C Radisky
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Three metabolic pathways replenishing the one-carbon pool collectively support growth and virulence of Listeria monocytogenes

    Sandra Freier, Sarah Frentzel ... Sven Halbedel
    Spontaneous reactivation of an interrupted biosynthetic gene reveals unexpected plasticity in folate-dependent one-carbon metabolism that promotes growth and virulence in the foodborne human pathogen Listeria monocytogenes.
    1. Neuroscience

    Overt visual attention modulates decision-related signals in the frontal cortex

    Blair RK Shevlin, Rachael Gwinn ... Ian Krajbich
    Brain activity in the pre-supplementary motor area and dorsolateral prefrontal cortex represents gaze-weighted accumulated evidence signals in value-based decision-making.
    1. Microbiology and Infectious Disease

    Replicative slender bloodstream forms complete transmission of Trypanosoma brucei without prior differentiation into stumpy forms

    Carina Praisler, Jaime N Lisack ... Markus Engstler
    Trypanosoma brucei transmission through the tsetse fly does not require prior differentiation into the stumpy bloodstream form, revealing greater flexibility in the parasite life cycle.
    1. Neuroscience

    Modeling the prodromal phase of Alzheimer’s disease: Selective amyloid-driven failure of cholinergic medial septal neurons perturbs REM sleep, cognition, emotion, and broadcasts pathology in aging mice

    Mathieu Nollet, Wei Ba ... William Wisden
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Social Influence in Donation Behavior: The Effect of Mean, Variance, and Psychopathy

    Tao Jin, Shen Zhang ... Iris Vilares
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors

    Rixu Cong, Huiran Li ... Chen Zhang
    The gating kinetics of AMPARs are regulated by ABHD6 in a TARP γ-2-dependent manner.
    1. Cell Biology
    2. Immunology and Inflammation

    MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide

    Michelle C Rice, Maria Imun ... Changhan Lee
    MOTS-c, a mitochondrial-encoded microprotein, has immunological origins and functions, revealing for the first time that our immune system is encoded by both co-evolved nuclear and mitochondrial genomes.
    1. Immunology and Inflammation

    TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

    Philip V Seegren, Amir Rattner ... Jeremy Nathans
    In a mouse model of E. coli meningitis, non-myeloid TLR4 signaling is a key determinant of the inflammatory response in all leptomeningeal cells and of the increase in vascular permeability.
    1. Developmental Biology
    2. Evolutionary Biology

    Latent gene network expression underlies partial re-evolution of a polyphenic trait in the worker caste of ants

    Angelly Vasquez-Correa, Johanna Arnet ... Ehab Abouheif
    Latent developmental potential facilitates trait re-evolution with novel phenotypic patterns, adding a new perspective to understanding of the origins of novel traits in evolutionary and developmental biology.
    1. Neuroscience

    Economic and social modulations of innate decision-making in mice exposed to visual threats

    Zhe Li, Jiahui Wang ... Ya-tang Li
    Threat, reward, and social hierarchy jointly shape innate defensive decisions through vigilance-dependent value integration.
    1. Neuroscience

    Local inhibitory dynamics underpin temporal integration and functional segregation between barrels and septa in the mouse barrel cortex

    Ali Özgür Argunşah, Tevye Jason Stachniak ... Theofanis Karayannis
    Elfn1-mediated synaptic facilitation onto somatostatin-positive interneurons drives the local lateral inhibition required to functionally segregate cortical barrel and septal processing domains in mice.
    1. Neuroscience

    A single evidence accumulation process informs perceptual choices and subsequent confidence reports

    John P Grogan, Luc Vermeylen ... Redmond G O’Connell
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Sequential and coordinated control of human plasma cell differentiation by IRF4 and BLIMP1 utilizing a discriminating ISRE/EICE motif lexicon

    Louis C Lau, Sneha Lal ... Harinder Singh
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology

    Molecular mechanisms underlying the prepupal-instar-forming metamorphosis in black soldier fly (Hermetia illucens)

    Lingtao Zhang, Masami Shimoda, Chieka Minakuchi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    cuBNM: GPU-Accelerated Brain Network Modeling

    Amin Saberi, Bin Wan ... Sofie L Valk
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    The digital sphinx: Can a worm brain control a fly body?

    Bingni W Brunton, Elliott TT Abe ... John C Tuthill
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology

    The evolution of cavefish odor perception shifts fish response from avoidance to approach when exposed to alarm and death odors

    Zachary Harkinish-Murray, Tiffany Chan ... Robert A Kozol
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Physiology
    2. Structural Biology and Molecular Biophysics

    Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

    Giulia Arecchi, Marica Dente ... Chiara Tesi
    Label-free optical imaging provides a direct readout of relaxed myosin conformational states in skeletal and cardiac muscle.
    1. Neuroscience

    A behavioral architecture for realistic simulations of Drosophila larva locomotion and foraging

    Panagiotis Parthenios Sakagiannis, Anna-Maria Jürgensen, Martin Paul Nawrot
    A three-layered modular architecture unifies diverse computational models of Drosophila larval behavior, enabling realistic closed-loop simulations from locomotion through chemotaxis to associative learning.
    1. Neuroscience

    EEG-Neurofeedback Targeting Gamma Oscillations at the Parieto-Occipital Region Reduces Pain Perception

    Xiangyue Zhao, Hao Sun ... Li Hu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Multisensory learning recruits visual neurons into an olfactory memory engram

    Zeynep Okray, Nils Otto ... Scott Waddell
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Physiology

    mTOR regulates longevity through a bile-acid like hormonal mechanism and DHS-26/DHRS1

    Klara Schilling, Alex Zaufel ... Adam Antebi
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Reduced dorsal CA1 Activity Limits Retention of the Temporal Component of Declarative Memory in the Cntnap2 Knockout Mouse Model of Autism

    Elise C Rawlinson, Michael H McCullough ... Nathalie Dehorter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Inhibiting the interaction between the mitochondrial receptor Tom70 and SARS CoV 2 Orf9b with small molecules

    CJ San Felipe, Kliment A Verba ... James S Fraser
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bicarbonate receptor GPR30

    Shota Kaneda, Airi Jo-Watanabe ... Osamu Nureki
    Cryo-electron microscopy structure of human G-protein-coupled receptor 30 in the presence of bicarbonate ions revealed unique extracellular pockets and critical residues for bicarbonate binding and activation.
    1. Genetics and Genomics

    Sibling chimerism among microglia in marmosets

    Ricardo CH del Rosario, Fenna M Krienen ... Steven A McCarroll
    Sibling-derived chimerism in marmosets is found only in cells of hematopoietic origin, especially microglia and macrophages in the brain, whose proportions vary widely across individuals and brain regions.
    1. Immunology and Inflammation
    2. Neuroscience

    The G-protein coupled receptor GPR34 promotes the homeostatic state of microglia and restrains the disease-associated microglial response in an Alzheimer’s disease model

    Ana Geller, Min Jee Kwon ... Prabhat S Kunwar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Lineage tracing and live-cell imaging reveal that NeuroD1 does not reprogram microglia into neurons

    Xiaoyu Li, Yuxin Li ... Yanxia Rao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Plant Biology
    2. Ecology

    Genetic canalization of nutrient resorption: evidence from a widespread grass under effective salt stress

    Lele Liu, Wenyi Sheng ... Weihua Guo
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition

    Natalie Gonzaga-Saavedra, Eleanor A Degen ... Shelby A Blythe
    Epigenomics and quantitative imaging are used to investigate the re-establishment of histone modifications associated with the Polycomb group of epigenetic regulators during the Drosophila maternal-to-zygotic transition.
    1. Neuroscience

    Parkinson’s disease-associated PINK1 loss disrupts ensheathing glia and causes dopaminergic neuron synapse loss

    Lorenzo Ghezzi, Sabine Kuenen ... Patrik Verstreken
    Parkinson’s disease-linked Pink1 loss disrupts protective glial support, and targeting glial vesicle trafficking preserves dopaminergic synapses.
    1. Neuroscience

    Population-level temporal decoding and dynamical structure in frontostriatal circuits during decision making

    Adam B Goldring, Anandita De ... Timothy D Hanks
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Rhythmic temporal structure organizes recurrent dynamics to support sequential working memory

    Yitao Qin, Yun Yang ... Tielin Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    A transient hypothalamic CRH signal coordinates social investigation in mice

    Ibukun Akinrinade, Meenakshi Pardasani ... Jaideep S Bains
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Alzheimer disease: The proposed role of tanycytes in the formation of tau tangles and amyloid beta plaques in human brain

    Ruth Fabian-Fine, Abigail G Roman, Adam L Weaver
    Not revised
    Reviewed Preprint v1
    • Inadequate
    1. Microbiology and Infectious Disease

    An innovative tool for non-invasive contact-free pathogen monitoring in animal saliva

    Maristela Martins de Camargo, Aspen Caim Fernandes Gonçalves ... Dawn Zimmerman
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    Five-layer systems analysis of Leishmania stage differentiation reveals an essential role for protein degradation in parasite development

    Pascale Pescher, Thibaut Douché ... Gerald F Späth
    Integrated multi-omics profiling provides evidence for coordinated changes across RNA turnover, translation, phosphorylation, and protein degradation during Leishmania differentiation, generating candidate therapeutic targets for leishmaniasis.
    1. Cell Biology

    Aging-associated increase of GATA4 levels in articular cartilage is linked to impaired regenerative capacity of chondrocytes and osteoarthritis

    Meagan J Makarczyk, Yiqian Zhang ... Hang Lin
    GATA4 plays critical roles in chondrocyte aging, which may serve as a target to rejuvenation old chondrocytes.
    1. Neuroscience

    Human brain-wide activation of sleep rhythms

    Haiteng Wang, Qihong Zou ... Yunzhe Liu
    Simultaneous EEG–fMRI recordings in 107 human participants link coupled slow oscillations and sleep spindles to thalamic coordination of hippocampal–prefrontal communication during deep sleep.
    1. Neuroscience

    Closed-loop neurofeedback reshapes preparatory brain states to bias subsequent pain processing

    Yinhua Zhang, Shuang Qiu ... Weiwei Peng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    A shared neural code for gender across faces, bodies, and objects in the human brain

    Wenjie Liu, Xiqian Lu ... Yi Jiang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Physiology

    Reproductive experience promotes permanent body growth independently of growth hormone

    Gabriel O de Souza, Willian O dos Santos ... Jose Donato
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Essential role for plasma membrane glutamate transporters in stimulus intensity coding in auditory neurons

    Tenzin Ngodup, Laurence O Trussell
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Hierarchical Neural Circuit Theory of Normalization and Inter-areal Communication

    Asit Pal, Shivang Rawat ... Stefano Martiniani
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Spine nanostructure profiling of cultured neurons from mouse models reveals a schizophrenia-linked role for Ecrg4

    Yutaro Kashiwagi, Qingrui Liu ... Shigeo Okabe
    Population-level analysis of dendritic spine nanostructure identifies distinct synaptic signatures of schizophrenia and autism, revealing Ecrg4 as a regulator of schizophrenia-associated spine pathology.
    1. Ecology

    Global relationships between body size and urban affinity across more than 30,000 plant and animal species

    Corey T Callaghan, Diana E Bowler ... Thomas Merckx
    Across the tree of life, urban communities are consistently characterized by many urban-avoiding species and few urban exploiters, revealing a general pattern in biodiversity responses to urbanization.
    1. Microbiology and Infectious Disease

    A dual role for PGLYRP1 in host defense and immune regulation during B. pertussis infection

    David M Rickert, Sasha Cardozo ... Ciaran Skerry
    Bordetella pertussis hijacks the host innate immune protein PGLYRP1 via tracheal cytotoxin to suppress inflammation and evade killing, revealing a novel immune evasion strategy.
    1. Neuroscience

    In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging

    Vasileios Ioakeimidis, Marco Palombo ... Claudia Metzler-Baddeley
    Novel SANDI diffusion modelling reveals Huntington’s disease-related striatal abnormalities in proxy soma measures, explaining atrophy and motor impairment, and supporting SANDI indices as in vivo biomarkers of human neurodegenerative processes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Divergent C. elegans toxin alleles are suppressed by distinct mechanisms

    Stefan Zdraljevic, Laura Walter-McNeill ... Leonid Kruglyak
    A maternal toxin-antidote element has degenerated into an antidote-only remnant in some Caenorhabditis elegans isolates, while in others, the toxin may instead be silenced by small RNAs.
    1. Cell Biology

    Pre-rRNA represses gene transcription in the XY body of male germ cells

    Linlin Chen, Xiaochen Gai ... Xiaochun Yu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Evolutionary Biology

    Frequency dynamics predict viral fitness, antigenic relationships and epidemic growth

    Marlin D Figgins, Trevor Bedford
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Computational and Systems Biology
    2. Cancer Biology

    dbGIST: An LLM-Assisted Multi-Omics Resource for Target Exploration and Cross-Dataset Validation in Gastrointestinal Stromal Tumors

    Zhao Sun, Qian Zhao ... Yang Fu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Functional Convergence of Genetically Diverse B-Cell Receptors in Simian-HIV Infected Rhesus Macaques

    Shengli Song, Hui Li ... Garnett Kelsoe
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Plant Biology

    Quantitative modelling of biological response dynamics reveals novel patterns in plant volatile signalling

    Jamie M Waterman, Gareth J Moore ... Matthias Erb
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A tool to pulse-label yeast nuclear pore complexes in imaging and biochemical experiments

    Annemiek C Veldsink, Jonas S Fischer ... Liesbeth M Veenhoff
    A non-perturbative nanobody-based strategy was developed for pulse-labeling yeast nuclear pore complexes to selectively capture Nup84-containing complexes for imaging and biochemical analysis.
    1. Cancer Biology
    2. Medicine

    A novel prognostic score based on carbohydrate antigen 125, alpha-fetoprotein and carcinoembryonic antigen for Predicting postoperative prognosis in endometrial cancer: Results from a retrospective cohort study

    Zi-hao Wang, Qing Li ... Xiao-xin Ma
    1. Physics of Living Systems

    A unifying model of T-cell signaling protein condensates in reconstitution experiments

    Yannick Azhri Din Omar, Simou Sun ... Arup K Chakraborty
    1. Genetics and Genomics
    2. Medicine

    Translational reading frame predicts the pathogenicity of C-terminal frameshift deletions in MeCP2

    Jacky Guy, Elena Hein ... Adrian Bird
    The pathogenicity of MECP2 C-terminal deletions is determined by translational reading frame, enabling prediction of clinical outcome and a shared therapeutic genome editing strategy.
    1. Neuroscience

    Accumulation of neural state transitions in dorsomedial striatum predicts patch foraging decisions

    Elissa Sutlief, Shichen Zhang ... Marshall G Hussain Shuler
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1

    Jill von Velsen, Pauline Juyoux ... Matthew W Bowler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Characterising semantic prioritisation in visual working memory

    Casper Kerrén, Carlos González-García, Juan Linde-Domingo
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Medicine

    Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study

    Carolyne Jie Huang, Samuel Pawel ... Rachel Heyard
    A simulation study shows that metrics suggested to assess replication studies are useful in the translation context, but researchers need to clarify their translation goals a priori.
    1. Neuroscience

    Mood computational mechanisms underlying increased risk behavior in adolescent suicidal patients

    Zhihao Wang, Tian Nan ... Bastien Blain
    Adolescent suicidality is linked to riskier choices through stronger attraction to high-reward gambles and blunted mood responses to safe rewards.
    1. Neuroscience

    Functional specialization of mPFC-BLA and mPFC-NAc pathways in affective state representation

    Chien-Hsien Lai, Gyeongah Park ... Jianyang Du
    Separate prefrontal output channels preferentially track anxiety, exploration, and social preference, revealing how emotional context is organized into adaptive behavior.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Combinatorial transcription factor interactions drive modular gene regulatory networks

    Jialei Duan, Boxun Li ... Gary C Hon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Cancer Biology

    A Rare Nestin-Expressing Granule Cell Precursor Subpopulation Underlies SHH Medulloblastoma Formation

    Salsabiel El Nagar, Yinwen Liang ... Alexandra L Joyner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    LRRK2 couples brain-derived neurotrophic factor (BDNF) signaling to synaptic actin remodeling, defining a novel mechanism of LRRK2 synaptic function and highlighting early, targetable pathways in Parkinson’s disease.
    1. Genetics and Genomics

    The cistrome response to hypoxia in human umbilical vein endothelial cells

    Ayush Singh, Viktor Pastukh ... Hank W Bass
    The genomic response of endothelial cells to hypoxia via MOA-seq transcription factor occupancy profiling identified known and novel HIF1A-associated and independent cis-regulatory elements, which defined ten distinct hypoxic kinetic clusters.
    1. Stem Cells and Regenerative Medicine

    Endometrial cells with high ALDH activity contribute to uterine development and regeneration

    Suni Tang, Anna Catherine Unser ... Diana Monsivais
    ALDH1A1+ cells are a group of hormone-sensitive stem cells that contribute to endometrial development and repair.
    1. Microbiology and Infectious Disease

    Pathogen-phage geomapping to overcome resistance

    Camilla Do, Keiko Christine Salazar ... Anthony W Maresso
    Targeted ecological sampling combined with a portable enrichment device rapidly yields a diverse array of bacteriophages against drug-resistant pathogens.
    1. Microbiology and Infectious Disease

    Nanoscopy reveals heparan sulfate clusters as docking sites for SARS-CoV-2 attachment and entry

    Sue Han, Xin Wang ... Ling-Gang Wu
    Cell-surface heparan sulfate clusters, not the generally assumed ACE2, mediate SARS-CoV-2 attachment and endocytic entry, fundamentally revising the viral entry paradigm and establishing heparan sulfate as a primary therapeutic target.
    1. Cancer Biology

    Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia

    Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
    Mechanical interactions at the interface of mutant and wild-type cell populations govern tissue-specific responses to oncogenic transformation in epithelia, causing mutants to be extruded, spatially restrained, or undergo persistent expansion.
    1. Neuroscience

    Brainstem neurons coordinate the bladder and urethral sphincter for urination

    Xing Li, Xianping Li ... Jiwei Yao
    Estrogen receptor 1 (ESR1)-positive neurons in the pontine micturition center govern detrusor–sphincter coordination via three distinct spinal projections, representing a therapeutic target for detrusor–sphincter dyssynergia and associated voiding dysfunction.
    1. Neuroscience

    Distinct neural representations of perceptual and numerical absence in the human brain

    Benjy Barnett, Stephen M Fleming
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    An integrated human forebrain organoid reveals microglia-mediated CD8+ T cell recruitment and neuroimmune dysfunction in Alzheimer’s disease pathology

    Yilin Feng, Feifei Yu ... Shaohua Ma
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Efficient and reproducible pipelines for spike sorting large-scale electrophysiology data

    Alessio Paolo Buccino, Arjun Sridhar ... Joshua H Siegle
    Parallelized, cloud-compatible pipelines reduce spike sorting of large-scale neural recordings from weeks to hours, and enable systematic benchmarking of algorithms on hybrid data.
    1. Microbiology and Infectious Disease

    High-throughput quantification of population dynamics using luminescence

    Malte Muetter, Daniel C Angst ... Sebastian Bonhoeffer
    Tracking luminescent reporter light intensity is a fast, easy way to quantify population decline at high concentrations and tends to be a better proxy for biomass than for cell number.
    1. Neuroscience

    Boosting hyperalignment performance with age-specific templates

    Yuqi Zhang, Maria Ida Gobbini ... Ma Feilong
    Age-specific templates improve the quality of functional alignment using hyperalignment algorithms, and the improvement is consistent across age groups, validation analyses, and datasets.
    1. Microbiology and Infectious Disease

    Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection

    Christopher Peterson, Joshua Miller ... Vitaly V Ganusov
    Cooperation between individual virions of human cytomegalovirus at infecting cells leads to nonlinear scaling of cell infection probability with virion concentration.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

    Patrick B Jonker, Mumina Sadullozoda ... Alexander Muir
    Modeling the metabolic microenvironment of pancreatic tumors leads to the identification of polyunsaturated fatty acid metabolism as a vulnerability of pancreatic cancer.
    1. Cell Biology
    2. Neuroscience

    Engulfment by brain macrophages in a short-lived vertebrate

    Rahul Nagvekar, Angela N Pogson ... Anne Brunet
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Dense repeated sampling reveals impaired hierarchical integration of metacognitive confidence that scales with depression

    Paveen Phon-Amnuaisuk, Vanessa Teckentrup ... Claire M Gillan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Neuroscience

    Virtual reality reveals fine-scale alterations in behaviour following loss of the ADHD-linked gene adgrl3.1 in zebrafish

    Phoebe Reynolds, Emily Read ... Robert Hindges
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Deletion of neuroligins from astrocytes does not detectably alter synapse numbers or astrocyte cytoarchitecture by maturity

    Samantha Rose Golf, Justin H Trotter ... Thomas C Südhof
    Genetic deletions in mouse models and human neuron co-cultures reveal that astrocytic neuroligins are dispensable for synapse formation and maintenance of normal astrocyte morphology, suggesting neuroligins serve alternative, unidentified roles.
    1. Neuroscience

    Pupil size reveals the perceptual quality and effortless nature of synesthesia

    Christoph Strauch, Casper Leenaars, Romke Rouw
    Synesthetes' pupils reflect the brightness of colors that they only see internally, making their hidden perceptual experience objectively measurable.
    1. Neuroscience

    Concurrent category-selective neural activity across the ventral occipito-temporal cortex supports a non-hierarchical view of human visual recognition

    Corentin Jacques, Jacques Jonas ... Bruno Rossion
    Face-selective neural activity occurs concurrently across the human ventral occipito-temporal cortex, challenging traditional hierarchical models of visual object recognition where response latencies increase along the cortical hierarchy.
    1. Neuroscience

    In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila

    Madeline P Marques, Bo Sun ... Hongjie Li
    In-situ glial cell-surface proteomics reveals DIP-β as a glial longevity factor that enhances intercellular communication and extends lifespan in aging Drosophila.
    1. Cell Biology

    Analysis of cancer mutations introduced into the Drosophila melanogaster Notch negative regulatory region uncovers a diversity of regulatory outcomes

    Hideyuki Shimizu, Martin Baron
    Heterogeneity in outcomes of differently located activating mutations of Notch indicates the need and potential for mutant specific targeting of Notch in cancer.
    1. Microbiology and Infectious Disease

    Niche exclusion of a lung pathogen in mice with designed probiotic communities

    Kelsey E Hern, Ashlee M Phillips ... Adam P Arkin
    Probiotic communities designed to inhibit a lung pathogen through niche exclusion show promise as a novel method of preventing respiratory infection.
    1. Neuroscience

    Heritability of movie-evoked brain activity and connectivity

    David C Gruskin, Daniel J Vieira ... Gaurav H Patel
    Genetic influences on how the brain processes complex naturalistic stimuli can be traced back to inherited control over stable spatial and temporal features of brain function.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Methylation clocks fail to generalize across genetically admixed individuals

    Sebastián Cruz-Gonzalez, Ogechukwu Okpala ... John A Capra
    DNA-methylation-based predictors of biological age often fail to generalize across human populations, limiting their utility as biomarkers of aging and disease.
    1. Stem Cells and Regenerative Medicine

    Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

    Ellen Späth, Svenja C Schüler ... Alessandro Ori
    Leiomodin 1 acts as a critical molecular switch during early muscle stem cell differentiation by sequestering the deacetylase SIRT1 in the cytoplasm to initiate the myogenic program.
    1. Neuroscience

    Thalamo-accumbal circuit adaptations following extended oxycodone abstinence

    Yanaira Alonso Caraballo, Yan Li ... Elena Chartoff
    Prolonged oxycodone abstinence strengthens paraventricular thalamus to nucleus accumbens shell glutamatergic transmission in both sexes, yet only females show enhanced relapse, dissociating shared synaptic plasticity from sex-specific relapse vulnerability.
    1. Neuroscience

    Demonstrating the ability of GABAergic cells in the zona incerta to modulate motivation

    Laura Korobkova, Brian G Dias
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Flexible brain state engagement predicts cognitive control transdiagnostically

    Jean Ye, Saloni Mehta ... Dustin Scheinost
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Rapid cortical reorganization tracks goal-directed sensorimotor learning in real time

    Anthony Renard, Georgios Foustoukos ... Carl CH Petersen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Structured stabilization in recurrent neural circuits through inhibitory synaptic plasticity

    Dylan Festa, Claudia Cusseddu, Julijana Gjorgjieva
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Split-trial analysis reveals the information capacity of neural population codes

    Dylan Le, Xue-Xin Wei
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Physiology

    Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

    Fangluo Chen, Muzna Saqib ... G William Wong
    Gene dosage imbalance due to the triplication of human chromosome 21 gene orthologs impairs whole-body glucose and lipid metabolism by disrupting homeostatic processes across major metabolic tissues.

Magazine

  1. Point of View: Scientific writing is not a murder mystery

    Charlotte A Dodson
    1. Neuroscience

    Visual Categorization: How monkeys carve up the visual world

    Binxu Wang
    1. Cell Biology

    Stress: How to give cells an identity crisis

    Paige Dillon, Julie Hollien
    1. Epidemiology and Global Health

    Malaria Prevention: Using mathematical models to optimise mosquito net distribution

    Carlos A Prete Jr
    1. Plant Biology

    Mixotrophy: An updated view of glucose pathways in cyanobacteria

    José Manuel García-Fernández