March 2026

Research articles

1. 1. Neuroscience

   Direction and orientation preferences in mouse superior colliculus and its retinal inputs exhibit a topography of cardinal biases atop locally mixed tuning

   Zhewen He, María Florencia González Fleitas ... Sylvia Schröder
2. 1. Neuroscience

   A mechanistic theory of planning in prefrontal cortex

   Kristopher T Jensen, Peter Doohan ... Timothy EJ Behrens
3. 1. Cell Biology
   2. Cancer Biology

   Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis

   Dana Naim, Zouheir Houhou ... Serge Roche
4. 1. Genetics and Genomics

   The CLAMP GA-binding transcription factor regulates heat stress-induced transcriptional repression

   Joseph Aguilera, Jingyue Duan ... Erica Larschan
5. 1. Evolutionary Biology

   Adaptive evolution to thermal stress underpins climate resilience in a cosmopolitan arthropod

   Gaoke Lei, Huiling Zhou ... Shijun You
6. 1. Microbiology and Infectious Disease

   A conserved mycobacterial nucleomodulin hijacks the host COMPASS complex to reprogram pro-inflammatory transcription and promote intracellular survival

   Liu Chen, Baojie Duan ... Aizhen Guo

   Mycobacterium tuberculosis deploys nucleomodulins to suppress COMPASS-dependent H3K4 methylation, dampening pro-inflammatory gene expression to enhance intracellular survival and uncovering an epigenetic immune-evasion strategy.
7. 1. Neuroscience

   The self-interest of adolescents overrules cooperation in social dilemmas

   Xiaoyan Wu, Hongyu Fu ... Chao Liu

   Adolescents value reciprocity less than adults, limiting cooperation despite intact learning about others’ behavior.
8. 1. Medicine

   Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study

   Carolyne Jie Huang, Samuel Pawel ... Rachel Heyard
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Human CD1c-autoreactive T cells recognise Mycobacterium tuberculosis–infected antigen-presenting cells and display cytotoxic effector programmes

   Matthew Milton, Sahar H Farag ... Salah Mansour
10. 1. Developmental Biology

    The NTR/Prodrug Revolution: Tools for Controlling Cell Loss and Regeneration

    Gha-Hyun J Kim, Michael J Parsons
11. 1. Chromosomes and Gene Expression
    2. Medicine

    Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

    Fangluo Chen, Muzna Saqib ... G William Wong
12. 1. Immunology and Inflammation

    Nociceptor neurons control pollution-mediated neutrophilic asthma

    Jo-Chiao Wang, Amelia Kulle ... Sebastien Talbot

    Air pollution activates macrophage-derived artemin, sensitizing TRPA1 nociceptors to drive neutrophilic asthma, revealing new therapeutic targets for refractory airway inflammation.
13. 1. Neuroscience

    Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons

    Malin Schmidt, Anne Hoffrichter ... Philipp Koch

    Psilocin induces a durable neuroplastic state in human cortical neurons by enhancing BDNF signaling, neurite complexity, synaptogenesis, and synaptic network activity through 5-HT2A receptor-dependent mechanisms.
14. 1. Cell Biology
    2. Neuroscience

    Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration

    Bogdan Beirowski, Haoran Huang, Elisabetta Babetto

    Rigorous analysis in two knockout mouse lines demonstrates that death receptor 6 is not required for axon degeneration or Schwann cell injury responses following peripheral nerve transection.
15. 1. Neuroscience

    Human exploration strategically balances approaching and avoiding uncertainty

    Yaniv Abir, Michael Neil Shadlen, Daphna Shohamy

    Strategic avoidance of uncertainty emerges under high cognitive demands, enabling faster decisions without impairing learning.
16. 1. Genetics and Genomics

    A pilot study for whole proteome tagging in C. elegans

    Matthew Eroglu, Oliver Hobert
17. 1. Cell Biology
    2. Neuroscience

    Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila

    Francisco Muñoz-Carvajal, Nicole Sanhueza ... Felipe A Court
18. 1. Computational and Systems Biology

    Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability

    Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
19. 1. Biochemistry and Chemical Biology
    2. Developmental Biology

    NAD boosting mediated by CD38 inhibition drives reversal of a pathological vicious cycle of intracrine activity and inflammation in eyelid meibomian gland dysfunction

    Yuki Hamada, Takehide Sakamoto ... Masao Doi
20. 1. Developmental Biology

    Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans

    Marilina Raices, Fabiola Balmir ... Judith L Yanowitz

    HIM-5 emerges as a central scaffold that coordinates SPO-11 accessory complexes to control different aspects of meiotic DNA double-strand breaks, ensuring robust crossover formation on autosomes and the X chromosome.
21. 1. Cell Biology

    Human dynein–dynactin is a fast processive motor in living cells

    Vikash Verma, Patricia Wadsworth, Thomas J Maresca

    TIRF imaging of CRISPR-edited human cells shows dynein–dynactin complexes move processively with motility parameters consistent with the presence of multi-dynein assemblies (>one dynein heavy chain dimer per dynactin) in cells.
22. 1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi

    A DNA origami nanospring introduces a force-sensing technology that enables measurement of motor protein stall forces without optical trapping, detecting force changes in kinesin KIF1A and its disease-related mutants.
23. 1. Chromosomes and Gene Expression

    UV irradiation alters TFAM binding specificity and compaction of DNA

    Dillon E King, Emily E Beard ... Joel Meyer

    Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.
24. 1. Cancer Biology
    2. Cell Biology

    Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

    Qi Zhang, Yunfeng Wang ... Shaowei Zhao

    Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
25. 1. Chromosomes and Gene Expression

    Single Domain Antibody Inhibitors Target the Coiled Coil Arms of the Bacillus subtilis SMC complex

    Ophélie Gosselin, Michael Taschner ... Stephan Gruber
26. 1. Immunology and Inflammation

    During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics

    Kaylee SE van Dijk, Christina Begon-Pescia ... Maria Forlenza
27. 1. Developmental Biology

    Chromatin priming and Hunchback recruitment integrate spatial and temporal cues in Drosophila neuroblasts

    Ayanthi Bhattacharya, Hemalatha Rao, Sonia Q Sen
28. 1. Medicine

    Large-scale synthetic data enable digital twins of human excitable cells

    Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy
29. 1. Cell Biology

    Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan

    Naci Oz, Hetian Su ... Alaattin Kaya
30. 1. Developmental Biology
    2. Genetics and Genomics

    Single-cell co-mapping reveals relationship between chromatin state and gene expression in early zebrafish development

    Vivek Bhardwaj, Alberto Griffa ... Alexander van Oudenaarden
31. 1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    The spike tip protein of bacteriophage T4

    Yves Mattenberger, Ekaterina S Knyazhanskaya ... Dominique Belin
32. 1. Neuroscience

    Contributions of insula and superior temporal sulcus to interpersonal guilt and responsibility in social decisions

    Maria Gädeke, Tom Eric Willems ... Johannes Schultz

    Being responsible for a partner's adverse outcomes is associated with anterior insula activation, while the superior temporal sulcus tracks prediction errors for the partner's reward resulting from the participant's decisions.
33. 1. Neuroscience
    2. Physics of Living Systems

    A deep learning pipeline for mapping in situ network-level neurovascular coupling in multi-photon fluorescence microscopy

    Matthew W Rozak, James R Mester ... Bojana Stefanovic

    A novel pipeline for analyzing longitudinal two-photon microscopy data of cerebrovasculature in mice interrogates the vasculature network before and after optogenetic stimulation, revealing new insights into their coordination.
34. 1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Adaptor protein supersaturation drives innate immune signaling and cell fate

    Alejandro Rodriguez Gama, Tayla Miller ... Randal Halfmann

    In-cell biophysical analyses identify a sequence-encoded energy storage function of innate immune adaptor proteins that allows cells to respond quickly and decisively to pathogenic signals.
35. 1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Human genetic ancestry, Mycobacterium tuberculosis diversity, and tuberculosis disease severity in Dar es Salaam, Tanzania

    Michaela Zwyer, Zhi Ming Xu ... Daniela Brites

    The severity of active tuberculosis in a high-burden population is not explained by host or pathogen genetic variation, suggesting a dominant role for social and environmental factors.
36. 1. Computational and Systems Biology
    2. Neuroscience

    Visual information is broadcast among cortical areas in discrete channels

    Yiyi Yu, Jeffery N Stirman ... Spencer LaVere Smith

    Activity fluctuations, or noise correlations, are robust measures of neuronal connectivity and they reveal that neural circuity controls mixing of information at a granular level across millimeter-length scales.
37. 1. Cancer Biology
    2. Immunology and Inflammation

    The 1000⁺ mouse project for large-scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies

    Adam L Kenet, Sooraj Achar ... Grégoire Y Altan-Bonnet

    An automated bioluminescent image analysis framework, maRQup, parametrizes tumor dynamics and provides quantitative metrics, enabling large-scale evaluation and optimization of preclinical cancer immunotherapies.
38. 1. Biochemistry and Chemical Biology
    2. Cancer Biology

    In vitro reconstitutions suggest a general model for paradoxical activation of ARAF, BRAF, and CRAF by diverse RAF inhibitor types that does not rely on negative allostery

    Emre Tkacik, Dong Man Jang ... Michael J Eck
39. 1. Cancer Biology

    Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer

    Yue Zhang, Hanbing Wang ... Yue Wang

    Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor immunity.
40. 1. Physics of Living Systems

    The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients

    Majid Malboubi, Mohammad Hadi Esteki ... Guillaume Charras

    Stable pressure gradients can arise in cells from the combination of actomyosin-generated cortical tension, cytoplasmic poroelasticity, and water flows across the membrane.
41. 1. Neuroscience

    Control of innate olfactory valence by segregated cortical amygdala circuits

    James R Howe, Chung Lung Chan ... Cory M Root

    Topographically distributed plCoA populations direct innate olfactory responses by signaling to divergent valence-specific targets, linking upstream olfactory identity to downstream valence behaviors, through a population code.
42. 1. Computational and Systems Biology
    2. Medicine

    Global molecular landscape of early MASLD progression in human obesity

    Qing Zhao, William De Nardo ... Philipp Kaldis

    GTPases could be drivers of liver fibrosis in MASLD and potential future therapeutic targets.
43. 1. Microbiology and Infectious Disease

    4-Aminoquinolines block heme iron reactivity and interfere with artemisinin action

    Melissa Rosenthal, Daniel E Goldberg

    Chloroquine interferes with artemisinin activation, and such interactions should be considered when formulating antimalarial drug combinations.
44. 1. Neuroscience

    Alcohol attenuates CRF-induced excitatory effects from the extended amygdala to dorsostriatal cholinergic interneurons

    Amanda Essoh, Xueyi Xie ... Jun Wang

    Stress-related corticotropin-releasing factor signaling directly modulates striatal cholinergic circuits, and alcohol exposure disrupts this control, revealing a circuit mechanism linking stress, alcohol use, and impaired behavioral flexibility.
45. 1. Neuroscience

    Dynamic regulation of mRNA acetylation at synapses by spatial memory in mouse hippocampus

    Hai-Qian Zhou, Zhen Zhu ... Dong-Min Yin

    NAT10-mediated mRNA acetylation links neural activity to local protein synthesis at synapses, influencing memory consolidation.
46. 1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Superoxide dismutases maintain niche homeostasis in stem cell populations

    Olivia Majhi, Aishwarya Chhatre ... Devanjan Sinha

    Superoxide dismutases, particularly Sod1, differentially tune redox signaling of germline and cyst stem cells, enabling their self-renewal and differentiation, thereby maintaining Drosophila testicular stem cell homeostasis.
47. 1. Genetics and Genomics
    2. Evolutionary Biology

    Mosaic of somatic mutations in one of Earth’s largest organisms, Pando

    Rozenn M Pineau, Karen E Mock ... Zachariah Gompert
48. 1. Neuroscience

    Early Sleep-Dependent Sensory Gating in the Olfactory System

    Diego Serantes, Diego Gallo ... Matías Cavelli
49. 1. Cancer Biology

    Turning aging cells into a live vaccine: engineered senescent cancer cells with adjuvant celecoxib for immunotherapy

    Yuewei Wang, Ante Ou ... Yongzhuo Huang
50. 1. Developmental Biology
    2. Evolutionary Biology

    Developmental, regenerative, and behavioral dynamics in acoel reproduction

    Vikram Chandra, Samantha Elizabeth Tseng ... Mansi Srivastava

    Studying the reproductive life history of an acoel reveals that a body-size-dependent program regulates organ growth and regeneration dynamics and discovers a novel form of egg-laying behavior.
51. 1. Immunology and Inflammation

    Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions

    Yu Hong, Xiaofang Si ... Yu Zhang

    Inactivation of beta 1,4-galactosyltransferase 1 leads to enhanced T-cell receptor activation and CD8⁺ T-cell function by affecting the galactosylation of T-cell receptor and CD8.
52. 1. Genetics and Genomics

    Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicing

    Karen Larisssa Pereira de Castro, Jose M Abril ... William S Fagg

    Competition between Quaking and SF1 for a subset of ACUAA intron branch sites influences alternative splicing in different tissues and organisms.
53. 1. Cell Biology

    Specific GPCRs elicit unique extracellular vesicle miRNA array signatures

    Xiao Shi, Michelle C Palumbo ... Aaron J Janowsky

    Unique extracellular vesicle microRNA signatures resulting from G protein-coupled receptor activation indicate distinct downstream signaling and functional networks by receptor, with implications for developing new drugs and understanding their long-term and off-target effects.
54. 1. Neuroscience

    Blood-derived dietary protein promotes sleep in the mosquito Aedes aegypti

    Jiwei Zhang, Hitoshi Tsujimoto ... Alex C Keene
55. 1. Developmental Biology
    2. Evolutionary Biology

    Latent gene network expression underlies partial re-evolution of a polyphenic trait in the worker caste of ants

    Angelly Vasquez-Correa, Johanna Arnet ... Ehab Abouheif
56. 1. Neuroscience

    Cortex-wide Dynamics of Internal Decisions About Behavioral Context

    Joshua Calder-Travis, Ruud L van den Brink ... Tobias H Donner
57. 1. Neuroscience

    Inhibition of Slc17a7 expressing neurons in the basolateral amygdala which project to the nucleus accumbens shapes the fidelity of motivated behavior

    William D Mercer, Iltan Aklan ... Kyle H Flippo
58. 1. Cell Biology

    Polo-like kinase phosphorylation of the orphan kinesin KIN-G negatively regulates centrin arm biogenesis in Trypanosoma brucei

    Yasuhiro Kurasawa, Qing Zhou ... Ziyin Li
59. 1. Microbiology and Infectious Disease

    The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

    Sheng-Li Ming, Meng-Hua Du ... Bei-Bei Chu
60. 1. Neuroscience

    Capturing instantaneous neural signal-behavior relationships with concurrent functional mixed models

    Al W Xin, Erjia Cui ... Gabriel Loewinger
61. 1. Structural Biology and Molecular Biophysics

    Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens

    Jongbin Kim, Galen J Correy ... James S Fraser
62. 1. Neuroscience
    2. Computational and Systems Biology

    Policy-Gradient Reinforcement Learning as a General Theory of Practice-Based Motor Skill Learning

    Adrian M Haith
63. 1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Expression of specific var gene subtypes is differentially associated with severe malaria syndromes

    Henry Ndugwa, Michelle Muthui ... Abdirahman I Abdi
64. 1. Evolutionary Biology

    Earliest evidence of elephant butchery at Olduvai Gorge (Tanzania) reveals the evolutionary impact of early human megafaunal exploitation

    Manuel Dominguez-Rodrigo, Enrique Baquedano ... Audax Mabulla

    The discovery of the earliest direct evidence of systematic proboscidean butchery at Olduvai Gorge demonstrates that by 1.8 Ma early hominins had strategically integrated megafaunal exploitation into their subsistence systems.
65. 1. Neuroscience

    iGABASnFR2 is an improved genetically encoded protein sensor of GABA

    Ilya Kolb, Jeremy P Hasseman ... Glenn C Turner

    An improved genetically encoded GABA sensor enables the most effective direct optical measurement of inhibitory neurotransmission to date.
66. 1. Neuroscience

    Visual experience shapes functional connectivity between occipital and non-visual networks

    Mengyu Tian, Xiang Xiao ... Marina Bedny

    At birth, infant visual cortex connectivity resembles that of blind adults, while lifetime visual experience enhances long-range functional connectivity between visual cortices, sensorimotor systems, and dampens connectivity with executive networks.
67. 1. Neuroscience

    Formation of task representations and replay in mouse medial prefrontal cortex

    Hamed Shabani, Hannah Muysers ... Christian Leibold

    Longitudinal calcium imaging in the medial prefrontal cortex reveals the emergence of de novo task representations and reward-associated replay.
68. 1. Neuroscience

    Functional connectivity-based attractor dynamics of the human brain in rest, task, and disease

    Robert Englert, Balint Kincses ... Tamas Spisak

    Functional connectivity reveals brain attractors that match predictions of free‑energy‑minimizing attractor theory, yielding an interpretable generative model of brain dynamics in rest, task, and disease.
69. 1. Microbiology and Infectious Disease

    Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival

    Liu Chen, Baojie Duan ... Aizhen Guo

    Mycobacterium tuberculosis utilizes nucleomodulins to disrupt host inflammatory responses and lysosomal maturation, uncovering a novel strategy for immune evasion and intracellular survival.
70. 1. Neuroscience

    Profiling presynaptic scaffolds using split-GFP reconstitution reveals cell-type-specific spatial configurations in the fly brain

    Hongyang Wu, Yoh Maekawa ... Hiromu Tanimoto

    Profiling endogenous Bruchpilot proteins in multiple cell types in mushroom bodies uncovered multilayered spatial configurations of active zones, from stereotyped intracellular distribution patterns to local arrangements of neighboring synapses.
71. 1. Developmental Biology
    2. Plant Biology

    Alternative splicing of PIF4 regulates plant development under heat stress

    María Niño-González, Benjamin Alary ... Guiomar Martín
72. 1. Evolutionary Biology

    No evidence for disassortative mating based on HLA in a small-scale, endogamous population

    Gillian L Meeks, Brooke Scelza ... Brenna M Henn
73. 1. Genetics and Genomics

    ARID5B mutations cause a neurodevelopmental syndrome with neuroinflammation episodes

    Hendrikus J van Heesbeen, Nazim Rabouhi ... Philippe M Campeau
74. 1. Cell Biology
    2. Chromosomes and Gene Expression

    Dynamic RNA Polymerase compartments organize the transcription of gene clusters

    Yi-Hui Wang, Hannah L Hertz, Wen Tang
75. 1. Cancer Biology

    Nerve Injury-Induced Protein 2 preserves lysosomal membrane integrity to suppress ferroptosis

    Jin Zhang, Miranda Bustamante ... Xinbin Chen
76. 1. Cell Biology
    2. Genetics and Genomics

    Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

    Kuei Ching Hsiung, Hannah Chapman ... David Gems
77. 1. Cancer Biology
    2. Chromosomes and Gene Expression

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells

    Ravi Kumar, Simon Couly ... Ashish Lal

    Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
78. 1. Developmental Biology
    2. Neuroscience

    The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

    Sen-Lin Lai, Chris Q Doe

    Fd4 is expressed in NB7-1 and new-born progeny where it activates terminal selector genes to produce lineage-specific neurons.
79. 1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Gueller ... Jan-Wilhelm Kornfeld

    Transcriptomic profiling on liver and adipose depots reveals tissue-specific and beige-fat–convergent responses to methionine restriction and cold, providing a high-quality resource to guide combinatorial lifestyle interventions for metabolic disease research.
80. 1. Neuroscience

    Identity and functions of monoaminergic neurons in the predatory nematode Pristionchus pacificus reveal nervous system conservation and divergence

    Curtis M Loer, Hyunsoo Yim ... Ray L Hong
81. 1. Neuroscience

    Individual Taste Preferences Predict Cortical Taste Dynamics but Are Modified by Experience

    Kathleen C Maigler, Jian-You Lin ... Donald B Katz
82. 1. Neuroscience
    2. Computational and Systems Biology

    High performance sorting of motor unit action potentials with EMUsort

    Sean O’Connell, Jonathan A Michaels ... Chethan Pandarinath
83. 1. Developmental Biology
    2. Neuroscience

    ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain

    Matthew T Schmitz, Jingwen W Ding ... Alex A Pollen
84. 1. Ecology

    Scanning and active sampling behaviours emerge from conserved insect neural circuits

    Cody A Freas, Antoine Wystrach
85. 1. Cell Biology

    Synergistic effects of deleting the tyrosine phosphatases Shp1 and Shp2 on megakaryopoiesis and thrombopoiesis in mice

    Elsa Barré, Marc-Damien Lourenco-Rodrigues ... Alexandra Mazharian
86. 1. Neuroscience

    Continuous partitioning of neuronal variability

    Anuththara Rupasinghe, Adam S Charles, Jonathan W Pillow
87. 1. Immunology and Inflammation

    A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

    Jordan Z Zhou, Bihui Huang ... Kang Chen
88. 1. Developmental Biology
    2. Genetics and Genomics

    A minimal tooth enhancer regulates dlx2b expression during zebrafish tooth formation: insights into cis-regulatory logic in organogenesis

    William R Jackman, Yujin Moon ... Yann Gibert
89. 1. Computational and Systems Biology
    2. Neuroscience

    Self-association enhances early attentional selection through automatic prioritization of socially salient signals

    Meike Scheller, Jan Tünnermann ... Jie Sui

    Self-related information automatically modulates early attentional selection into awareness through mechanisms distinct from physical salience, revealing an obligatory, individualized self-prioritization at the gateway to perception.
90. 1. Genetics and Genomics

    The impact of stability considerations on genetic fine-mapping

    Alan J Aw, Lionel Chentian Jin ... Yun S Song

    In statistical fine-mapping, signals stable across stratified subgroups can capture functionally important loci missed by covariate adjustment approaches, and prioritizing agreement between both approaches enhances functional variant discovery.
91. 1. Ecology
    2. Plant Biology

    Cardenolide toxin diversity impacts monarch butterfly growth and sequestration

    Anurag A Agrawal, Amy P Hastings, Paola Rubiano-Buitrago

    Confirming coevolutionary theory, monarch butterfly caterpillars show impaired growth and toxin sequestration when feeding on realistic cardenolide mixtures from their milkweed host plants.
92. 1. Neuroscience

    Distinct representational properties of cues and contexts shape fear and reversal learning

    Antoine Bouyeure, Daniel Pacheco-Estefan ... Nikolai Axmacher

    Fear updating relies on a flexible shift from generalized to item-specific, context-bound neural representations, revealing how the brain adapts to changing threat contingencies and why fear can return.
93. 1. Neuroscience

    Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain

    Anisa Azatovna Gumerova, Georgii Pevnev ... Vitaly Ryu

    Using RNAscope mapping provides the comprehensive, sex-specific atlas of vasopressin and its receptor gene expression across the murine brain, refining understanding of how vasopressin signaling is anatomically organized to regulate social behavior, stress responsivity, and homeostasis.
94. 1. Neuroscience

    The distinct role of human PIT in attention control

    Siyuan Huang, Lan Wang, Sheng He

    The human posterior inferotemporal cortex integrates endogenous and exogenous influences to form a unified attentional priority map for adaptive visual control.
95. 1. Neuroscience

    Retrieval practice prevents stress-induced inference impairment by restoring rapid memory reactivation

    Jinpeng Guo, Ruixin Chen ... Wei Liu
96. 1. Cell Biology

    Small brown planthopper infestation enhances it reproduction and insecticide tolerance by manipulating glucose distribution and levels in rice

    Hainan Zhang, Qi Zhang ... Jianjun Wang
97. 1. Neuroscience

    Spatially targeted inhibitory rhythms differentially affect neuronal integration

    Drew B Headley, Benjamin Latimer ... Satish S Nair

    Beta and gamma inhibitory rhythms are preferentially tuned to govern synaptic integration in layer 5 pyramidal neurons by differentially modulating responses to inputs targeting distal dendritic and perisomatic compartments.
98. 1. Computational and Systems Biology
    2. Genetics and Genomics

    Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

    Jie Lin, Yujian Wen ... Hao Zhu

    Compared with human-specific transcriptional factors, human-specific lncRNAs identified upon human lncRNAs’ orthologs in mammals have greatly evolved DNA-binding sites in archaic and modern humans in genes determining human traits.
99. 1. Neuroscience

    Readout and delayed transmission of initial afferent V1 activity in decisions about stimulus contrast

    Kieran S Mohr, Simon P Kelly

    Evidence is provided suggesting that aggregate neural activity at an early stage of visual processing (V1) can directly contribute to perceptual decisions in humans.
100. 1. Structural Biology and Molecular Biophysics

     Insights into substrate binding and utilization by hyaluronan synthase

     Zachery Stephens, Julia Karasinska, Jochen Zimmer

     Complementary biochemical and structural findings reveal molecular principles underlying substrate selectivity by a model hyaluronan synthase.
101. 1. Neuroscience

     A hypothalamo-septo-hippocampal circuit for REM sleep-dependent consolidation of social memory

     Tingliang Jian, Wenjun Jin ... Han Qin
102. 1. Immunology and Inflammation

     Temporal single-cell analysis reveals age-associated delay in immune resolution after respiratory viral infection

     Yue Wu, Chaofan Li ... Jie Sun
103. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules

     Mariam Ahmed Fouad, Christopher S Parry ... John Karanicolas
104. 1. Developmental Biology

     Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegans

     Zhimin Xu, Xiaoting Feng ... Yingchuan B Qi
105. 1. Neuroscience

     Precision cutaneous stimulation in freely moving mice

     Isobel Parkes, Ara Schorscher-Petcu ... Liam E Browne

     A closed-loop system delivers cutaneous optical stimulation during movement in freely behaving mice, enabling controlled somatosensory input in naturalistic settings.
106. 1. Computational and Systems Biology
     2. Physics of Living Systems

     A Coma Pattern-Based Autofocusing Method Resolves Bacterial Cold Shock Response at Single-Cell Level

     Sihong Li, Zhixin Ma ... Shuqiang Huang
107. 1. Cell Biology
     2. Evolutionary Biology

     Amino acid homorepeats act as buffers to maintain proteostasis and constrain the compatible sequence space of proteomes

     Yukihiro Murase, Naoki Kitamura ... Hisao Moriya
108. 1. Neuroscience

     Computational mechanisms for temporal integration in the anterior claustrum

     Kuenbae Sohn, Donghyeon Yoon ... Sukwoo Choi
109. 1. Cancer Biology

     Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in lung adenocarcinoma

     Gaoming Liao, Xinbin Yang ... Gang Xu
110. 1. Computational and Systems Biology
     2. Genetics and Genomics

     Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

     Luke J Dillard, Gina Calabrese ... Charles Farber

     Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles in the development of osteoporosis.
111. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Multiple modes of cholesterol translocation in the human Smoothened receptor

     Prateek D Bansal, Maia Kinnebrew ... Diwakar Shukla

     Multiple competing hypotheses concerning the cholesterol accessibility of oncoprotein Smoothened are quantitatively assessed and experimentally validated, showing that cholesterol takes two pathways from either membrane leaflet to the binding sites.
112. 1. Developmental Biology
     2. Genetics and Genomics

     A genome-wide MAGIC kit for recombinase-independent mosaic analysis in Drosophila

     Yifan Shen, Ann T Yeung ... Chun Han

     A comprehensive toolkit enables genome-wide, recombinase-independent mosaic analysis in Drosophila, permitting clonal analysis of pericentromeric genes, deficiency chromosomes, and interspecific hybrids previously inaccessible to standard methods.
113. 1. Developmental Biology

     Mouse germline cysts contain a fusome-like structure that mediates oocyte development

     Madhulika Pathak, Allan C Spradling

     Mammalian oocytes utilize a conserved combination of cell cycle control, cytoskeletal organization, and polarity pathways that are fundamentally shared with other vertebrates and invertebrates.
114. 1. Neuroscience
     2. Computational and Systems Biology

     Miniscope Processing Suite (MPS): An Intuitive, No-Code, Scalable Pipeline for Long-Duration Calcium Imaging

     Ari Peden-Asarch, Meredith Weinstock ... John F Neumaier
115. 1. Neuroscience

     Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation

     Sofie S Jacobsen, Allison B Morehouse ... Celia Kjaerby
116. 1. Microbiology and Infectious Disease

     Mycobacterium tuberculosis suppresses protective Th17 responses during infection

     Alex Zilinskas, Amir Balakhmet ... Sarah A Stanley
117. 1. Epidemiology and Global Health

     Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops

     Rachel H Clare, Adam Westhorpe ... Nicholas R Casewell
118. 1. Neuroscience

     Boosting Hyperalignment Performance with Age-specific Templates

     Yuqi Zhang, Maria Ida Gobbini ... Ma Feilong
119. 1. Neuroscience

     Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases

     Leonardo Diaz, Ally Xinyi Kong ... Yijie Geng
120. 1. Neuroscience

     The effect of physical activity on brain structure and cognitive function in the population-based cohort of LIFE-Adult-Study

     Polona Kalc, Rober Dahnke ... Christian Gaser
121. 1. Neuroscience

     Neural Mechanisms of Willed Attention Control

     Changhao Xiong, Qiang Yang ... Mingzhou Ding
122. 1. Neuroscience

     Movie reconstruction from mouse visual cortex activity

     Joel Bauer, Troy W Margrie, Claudia Clopath

     Naturalistic movie reconstruction from mouse visual cortex activity achieves high spatial and temporal fidelity.
123. 1. Neuroscience

     Peripheral anatomy and central connectivity of proprioceptive sensory neurons in the Drosophila wing

     Ellen Lesser, Anthony J Moussa, John C Tuthill

     Comprehensive mapping of wing sensory neurons in Drosophila reveals that some proprioceptors make direct connections onto flight steering motor neurons, enabling rapid feedback control during flight.
124. 1. Chromosomes and Gene Expression
     2. Genetics and Genomics

     EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

     Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky

     EPB41L4A-AS1, a highly expressed snoRNA host long noncoding RNA, has multiple functions, positive regulation in cis of the EPB41L4A gene and a trans-acting role in supporting proper nucleolar biology.
125. 1. Cell Biology

     Large-scale identification of plasma membrane repair proteins revealed spatiotemporal cellular responses to plasma membrane damage

     Yuta Yamazaki, Keiko Kono

     Proteome-scale visual screening in budding yeast provides a functional catalog of plasma membrane repair proteins and reveals the coordinated cellular responses at the bud tip and the damage site.
126. 1. Chromosomes and Gene Expression
     2. Genetics and Genomics

     Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins

     Roberta Carloni, Tadhg Devlin ... Robin C Allshire

     Synthetic proteins designed to bind specific repetitive DNA sequences in the Trypanosoma brucei genome allow the identification of proteins enriched over different DNA elements.
127. 1. Developmental Biology
     2. Genetics and Genomics

     Nup107 is a crucial regulator of torso-mediated metamorphic transition in Drosophila melanogaster

     Jyotsna Kawadkar, Pradyumna Ajit Joshi, Ram Kumar Mishra

     Y-complex nucleoporin, Nup107, can regulate ecdysone production by affecting the transcription of Halloween genes and levels of RTK receptor, torso, for the metamorphic transition from larva to pupa.
128. 1. Neuroscience

     Designing optimal perturbation inputs for system identification in neuroscience

     Mikito Ogino, Daiki Sekizawa ... Masafumi Oizumi
129. 1. Cell Biology

     Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis

     Changle Zhao, Yongxun Chen ... Jing Wei
130. 1. Neuroscience

     Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechanical pain hypersensitivity

     Riku Kawanabe-Kobayashi, Sawako Uchiyama ... Makoto Tsuda

     Stress activates a locus coeruleus–spinal dorsal horn noradrenergic circuit that drives mechanical pain hypersensitivity through Hes5-positive astrocytes.
131. 1. Computational and Systems Biology
     2. Microbiology and Infectious Disease

     Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria

     Zachary L Reitz, Bita Pourmohsenin ... Marnix H Medema

     Automated detection of metallophore biosynthesis reveals that metal-chelating non-ribosomal peptides are widespread, chemically diverse, and deeply rooted in bacterial evolution.
132. 1. Neuroscience

     Pupil size reveals the perceptual quality and effortless nature of synesthesia

     Christoph Strauch, Casper Leenaars, Romke Rouw
133. 1. Microbiology and Infectious Disease

     Evaluation of antibiotic and peptide vaccine strategies for mirror bacterial infections

     Alexander Kleinman, Joe Torres, Brian Wang
134. 1. Neuroscience

     Anesthesia Lowers Spatial Frequency Preference in the Primary Visual Cortex

     Jiahao Wu, Taisuke Yoneda ... Yumiko Yoshimura
135. 1. Developmental Biology
     2. Genetics and Genomics

     Drosophila melanogaster model of RVCL-S demonstrates age dependent disease progression

     Elena Gracheva, Abigail Matt ... Chao Zhou
136. 1. Genetics and Genomics

     Systematic yeast two-hybrid screening identifies novel functions for SET1C/COMPASS

     Pierre Luciano, Kihyun Park ... Vincent Géli
137. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Structural elucidation of the hexameric MmpS4-MmpL4 complex from Mycobacterium tuberculosis

     Jennifer C Earp, Nicolas P Lichti ... Markus A Seeger
138. 1. Neuroscience

     White Matter Stratification in Depression Predicts Multidimensional Antidepressant Responses

     Jiaolong Qin, Xinyi Wang ... Qing Lu
139. 1. Cell Biology

     Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila

     Yunpo Zhao, Jianli Duan ... Zhe Han

     A conserved glucagon signaling pathway links high-fat diet-induced metabolic imbalance to cardiac arrhythmia through hormone-producing cells and heart-innervating neurons that regulate rhythmicity.
140. 1. Developmental Biology

     Progressive mural cell deficiencies across the lifespan in a foxf2 model of cerebral small vessel disease

     Merry Faye E Graff, Emma EM Heeg ... Sarah J Childs

     Loss of foxf2 in zebrafish leads to a reduced pericyte progenitor pool in embryos and progresses to severe cerebrovascular defects over the lifespan, suggesting that cerebral small vessel disease in adults has roots in development.
141. 1. Neuroscience
     2. Physics of Living Systems

     “What” × “When” working memory representations using Laplace Neural Manifolds

     Aakash Sarkar, Shangfu Zuo ... Marc W Howard
142. 1. Biochemistry and Chemical Biology

     Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter

     Guanxing Chen, Qin Li ... Jiusheng Yan

     Regulatory stoichiometry in large-conductance potassium (BK) channels diverges by mechanism, separating single-subunit activation, graded pore contributions, and collective selectivity-filter control.
143. 1. Neuroscience

     High-fidelity neural speech reconstruction through an efficient acoustic-linguistic dual-pathway framework

     Jiawei Li, Chunxu Guo ... Yuanning Li

     Concurrent decoding of acoustic detail and linguistic structure enables natural, intelligible speech synthesis from limited human cortical recordings, resolving a fundamental constraint in neural speech reconstruction.
144. 1. Cell Biology

     Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

     Qian Lyu, Qingchao Li ... Huijie Zhao
145. 1. Developmental Biology
     2. Neuroscience

     Developmental sleep reallocation enables metabolic adaptation in desert flies

     Shuhao Li, Milan Szuperak ... Matthew S Kayser
146. 1. Cell Biology

     A high-throughput assay for the measurement of Ca²⁺-oscillations and insulin release from uniformly sized β-cell spheroids

     Stijn Robben, Patricia Davidson ... Thomas Voets
147. 1. Genetics and Genomics
     2. Immunology and Inflammation

     Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

     Conor J Howard, Nathan S Abell ... Diane E Dickel
148. 1. Developmental Biology

     Primordial cardiomyocytes orchestrate myocardial morphogenesis and vascularization but are dispensable for regeneration

     Jisheng Sun, Lu Chen, Jinhu Wang
149. 1. Microbiology and Infectious Disease

     Fine-tuning of outer membrane–peptidoglycan tethering by the redox-active lipoprotein LppB from Salmonella enterica

     Elisa S Pierre Despas, Seung-Hyun Cho ... Jean-François Collet
150. 1. Chromosomes and Gene Expression

     Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites

     Yatendra Kumar, Dipta Sengupta ... Wendy A Bickmore

     Acetylation of histone H3 at the nucleosome surface is associated with destabilised nucleosomes and is a useful new functional genomics mark for identifying regulatory regions of the mammalian genome.
151. 1. Computational and Systems Biology

     Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

     Zhiwei Huang, Songhao Luo ... Jiajun Zhang

     DNA damage reshapes genome-wide transcriptional bursting, with distinct burst size and frequency programs associated with differentiation, apoptosis, and survival decisions.
152. 1. Cell Biology

     SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy

     Grace Essuman, Midhat Rizvi ... Emmanuelle Cordat

     Distal renal tubular acidosis induced by some SLC4A1 variants is characterized by cytosolic pH alkalization, reduced ATP synthesis and defective autophagy degradative flux.
153. 1. Cell Biology
     2. Chromosomes and Gene Expression

     Contractile peri-nuclear actomyosin network repositions peripheral and polar chromosomes to promote early kinetochore–microtubule interactions

     Nooshin Sheidaei, John K Eykelenboom ... Tomoyuki U Tanaka
154. 1. Developmental Biology
     2. Genetics and Genomics

     Flexible and high-throughput simultaneous profiling of gene expression and chromatin accessibility in single cells

     Volker Soltys, Moritz Peters ... Yingguang Frank Chan
155. 1. Medicine

     Sperm motility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

     Charline Vilpreux, Paul Fourquin ... Jessica Escoffier

     Naked mRNA administration in the testes rescues sperm function, demonstrating a potential therapeutic approach for genetic male infertility.
156. 1. Biochemistry and Chemical Biology

     Intracellular expression of a fluorogenic DNA aptamer using retron Eco2

     Mahesh A Vibhute, Corbin Machatzke ... Hannes Mutschler

     Structure-guided engineering of a bacterial retron enables intracellular production of a light-up DNA aptamer whose purified DNA retains dye-activated fluorescence, establishing retrons as a scalable route to cellular aptamer synthesis.
157. 1. Neuroscience

     Dissociable dynamic effects of expectation during statistical learning

     Hannah H McDermott, Federico de Martino ... Ryszard Auksztulewicz

     Neural responses during statistical learning reveal dissociable dynamic effects of expectation, supporting the opposing process theory within trials while demonstrating contrasting effects across trials.
158. 1. Evolutionary Biology
     2. Neuroscience

     Toward neuroanatomical and cognitive foundations of macaque social tolerance grades

     Sarah Silvere, Julien Lamy ... Sebastien Ballesta

     Macaque’s social tolerance grades, through its underlying cognitive demands, shape subcortical structures volumes.
159. 1. Cell Biology

     Nuclear export governs TDP-43 phase transitions and cytoplasmic aggregation

     Natalie Chin, Qi Zhang ... Yihong Ye
160. 1. Genetics and Genomics

     Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity

     Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
161. 1. Cancer Biology

     Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

     Yanping Li, Xiaoxin Xie ... Qionghua Zhu
162. 1. Neuroscience

     PKMζ-PKCι/λ double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory

     Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
163. 1. Neuroscience

     The generalized Hierarchical Gaussian Filter

     Lilian Aline Weber, Peter Thestrup Waade ... Christoph Mathys
164. 1. Genetics and Genomics
     2. Evolutionary Biology

     Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype

     Tom Louis Ducrocq, Damien Laporte, Bertrand Daignan-Fornier
165. 1. Computational and Systems Biology
     2. Ecology

     Agent-based modeling reveals how bats navigate dense group emergences

     Omer Mazar, Yossi Yovel

     Acoustic jamming during bat emergence is weaker than expected because signal redundancy, echo integration, and simple movement rules enable robust navigation, as demonstrated by an agent‑based sensory-motor model.
166. 1. Computational and Systems Biology
     2. Genetics and Genomics

     JAX Animal Behavior System (JABS), a genetics-informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse

     Anshul Choudhary, Brian Q Geuther ... Vivek Kumar

     The JAX Animal Behavior System integrates standardized hardware, machine learning methods, and annotated datasets to enable reproducible behavioral phenotyping and genetic analysis across diverse mouse strains.
167. 1. Computational and Systems Biology

     Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data

     Guangzhao Cheng, Aki Vehtari, Lu Cheng

     SegPore refines raw signal segmentation and alignment in nanopore direct RNA sequencing and thereby boosts the performance of RNA modification detection from in vitro data at single-read resolution.
168. 1. Neuroscience

     Resolving synaptic events using subsynaptically targeted GCaMP8 variants

     Jiawen Chen, Junhao Lin ... Dion K Dickman

     New synaptically targeted GCaMP8 sensors and analysis tools capture calcium dynamics with the speed and sensitivity previously achievable only through electrophysiology and chemical dyes.