July 2026

Research articles

1. 1. Neuroscience

   Toothy: an interactive platform for dentate spike curation

   Kathleen N Esfahany, Amanda L Schott ... Jordan S Farrell
2. 1. Developmental Biology
   2. Neuroscience

   foxQ2 marks fast-acting brain interneurons including a subset of dopaminergic neurons innervating mushroom bodies and central complex in the beetle Tribolium castaneum

   Ying Pang, Bastian Klußmann-Fricke ... Gregor Bucher
3. 1. Computational and Systems Biology

   Benchmarking biochemical networks generated by large language models

   Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman

   Current general-purpose large language models generate signaling and metabolic networks with only modest accuracy relative to manually curated network models.
4. 1. Cell Biology

   Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life

   Hanane Hadj-Moussa, Megan Ulusan ... Jonathan Houseley

   Re-engineering a highly conserved metabolic pathway in yeast prevents age-related functional decline and proves that ageing is not inevitably linked to loss of fitness.
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter

   Matija Pečak, Christoph Nocker, Robert Tampé

   Hidden outward-facing intermediates and long-lived ATP-bound states reveal how ATP binding drives conformational dynamics in the heterodimeric ABC transporter TmrAB.
6. 1. Biochemistry and Chemical Biology
   2. Epidemiology and Global Health

   Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops

   Rachel H Clare, Adam Westhorpe ... Nicholas R Casewell

   Despite the variation in venom across the Bothrops snake genus, repurposed drugs demonstrated pan-species neutralisation in enzymatic, coagulation, and haemorrhage assays, highlighting their value as novel therapies for Neotropical snakebites.
7. 1. Neuroscience

   Comprehensive characterization of human color discrimination thresholds

   Fangfang Hong, Ruby Bouhassira ... David H Brainard

   Leveraging the smooth variation of internal noise makes comprehensive characterization of color discrimination practical, offering an efficient framework for studying perceptual limits across various sensory domains.
8. 1. Biochemistry and Chemical Biology

   Glycolipid MPIase is essential for the TAT (Twin-Arginine Translocation) pathway

   Hanako Nishikawa, Nachi Yamamoto ... Ken-ichi Nishiyama
9. 1. Neuroscience

   A hierarchical coordinate system for sequence memory in human entorhinal cortex

   Anna Shpektor, Jacob JW Bakermans ... Timothy EJ Behrens
10. 1. Developmental Biology

    Quantitative multi-scale morphodynamic analysis reveals ratchet-like collective DVE migration and epiblast retrograde cell flow during anterior patterning in the mouse embryo

    Matthew J Stower, Felix Y Zhou ... Shankar Srinivas
11. 1. Neuroscience

    Neural correlates of perceptual consciousness from within: A narrative review of human intracranial research

    François Stockart, Alexis Robin ... Nathan Faivre

    Combining intracranial recordings with no-report paradigms and computational models offers the clearest path yet to isolating genuine neural correlates of consciousness from their prerequisites and consequences.
12. 1. Cell Biology
    2. Physics of Living Systems

    The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch

    Robbert van der Pijl, Jochen Gohlke ... Coen Ottenheijm

    Titin-associated muscle ankyrin repeat proteins limit stretch-induced longitudinal muscle hypertrophy and link titin mechanosensing to mTOR signaling.
13. 1. Computational and Systems Biology
    2. Neuroscience

    Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions

    Richa Sirmaur, Rishikesh Narayanan

    Fundamental distinctions in the extracellular signatures of active-dendritic chemical and electrical synapses necessitate a revision of conventional interpretations of local field potentials centered on chemical synapses.
14. 1. Cell Biology

    N6-Adenosine Methylation of a Single Site in SARS-CoV-2 5′-UTR Promotes Translation

    Ammar Aly, Gary Scott ... A Pejmun Haghighi
15. 1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Preferential formation of NUP98-KDM5A condensates at specific H3K4me3-rich loci drives leukemogenic gene expression

    Augusto Berrocal, Jonathan E Sandoval ... Bo Huang
16. 1. Cancer Biology

    CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancer

    Beatrice Gini, Philippe Gui ... Collin M Blakely
17. 1. Biochemistry and Chemical Biology

    The structure-interaction model of polymyxin lipopeptides with human oligopeptide transporter 2

    Xukai Jiang, Yining Luo ... Jian Li
18. 1. Immunology and Inflammation

    ImPaqT, a Golden Gate-based immunological toolkit for zebrafish transgenesis

    Saskia Hurst, Christiane Dimmler, Mark R Cronan

    ImPaqT is an immune toolkit that enables modular and expandable cloning of zebrafish transgenes using Golden Gate-based cloning techniques.
19. 1. Genetics and Genomics
    2. Neuroscience

    Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12

    Paige M Lemen, Yanning Zuo ... Hao Chen

    A time-dependent genetic interaction between the µ opioid receptor and genes drives early morphine responses in mice, highlighting pathways linked to human substance use disorder.
20. 1. Cell Biology
    2. Cancer Biology

    Adaptive plasticity of aspartate metabolism in succinate dehydrogenase-deficient cancer cells

    David Sokolov, Eric Zheng ... Lucas B Sullivan
21. 1. Microbiology and Infectious Disease

    Multidimensional in vitro assay for antimalarial combination testing and pharmacodynamic modeling – the MULT-i² assay

    Angela Hellingman, Christin Gumpp ... Matthias Rottmann
22. 1. Neuroscience

    Multi-area activity in mouse motor cortex associated with one- and two-handed oromanual dexterity

    John M Barrett, Joshua I Glaser ... Gordon MG Shepherd
23. 1. Neuroscience

    CellCover defines marker gene panels capturing developmental progression in neocortical neural stem cell identity

    Lanlan Ji, An Wang ... Donald Geman

    In contrast to differential expression-based methods, which evaluate and select individual marker genes, CellCover identifies panels of genes that function together to define cell types.
24. 1. Neuroscience

    Behavioral signatures of post-decisional attention in preferential choice

    Ariel Zylberberg, Ian Krajbich, Michael N Shadlen

    Gaze patterns during value-based choice may reflect post-decision processes rather than a direct causal influence of attention on preference formation.
25. 1. Medicine

    Magnesium isoglycyrrhizinate alleviates alcohol-associated liver disease through targeting HSD11B1

    Lu Xiao, Lu Li ... Jia Xiao

    MgIG directly targets HSD11B1 to alleviate alcohol-associated liver disease by suppressing the HSD11B1–SREBP2–IDI1 pathway, thereby reducing hepatic steatosis, inflammation, and apoptosis.
26. 1. Neuroscience

    Excitatory cholecystokinin neurons in the CA3 area regulate the navigation learning and neuroplasticity

    Fengwen Huang, Abdul Baset, Stephen Temitayo Bello

    Cholecystokinin release from CA3 inputs to CA1 links local excitatory circuitry to hippocampal plasticity and spatial memory.
27. 1. Cell Biology
    2. Neuroscience

    Stable excitatory-inhibitory synapse balance despite dynamic turnover

    Krassimira A Garbett, James P Allen ... Richard C Sando

    Long-term live imaging and tracking approaches reveal a coordination between excitatory and inhibitory synapse assembly, despite continual spatiotemporal dynamics.
28. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

    Kely Catarine Matteucci, Nathalia PS Leite ... Ricardo T Gazzinelli

    TNF-driven metabolic reprogramming enhances glucose utilization in monocytes through inducible nitric oxide synthase (iNOS) and hypoxia-inducible factor 1α (HIF-1α), promoting parasite control and host resistance during Plasmodium infection.
29. 1. Computational and Systems Biology
    2. Neuroscience

    Active dendrites enable robust spiking computations despite timing jitter

    Thomas SJ Burger, Michael E Rule, Timothy O'Leary

    The brain computes rapidly and reliably using brief electrical impulses and likely exploits internal memory in nerve cells to achieve this more efficiently than existing computing hardware and neural networks.
30. 1. Structural Biology and Molecular Biophysics

    In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association

    Tamar Basiashvili, Joshua Hutchings ... Elizabeth Villa

    Type I and type II inhibitors differentially affect LRRK2 filament formation around microtubules, revealing an important consideration for Parkinson’s disease drug development.
31. 1. Neuroscience

    Sensory adaptation and pupil-linked arousal support flexible evidence accumulation during perceptual decision making

    Kara D McGaughey, Joshua I Gold

    Flexible evidence accumulation in dynamic environments relies on multiple mechanisms, including context-dependent modulations of sensory adaptation and pupil-linked arousal.
32. 1. Microbiology and Infectious Disease

    An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies

    Isabelle G Henshall, Jill Chmielewski ... Danny W Wilson

    Pathogens can use surface proteins to limit immune responses, and the finding that merozoite surface protein 2 has this property could help in Plasmodium falciparum malaria vaccine development.
33. 1. Immunology and Inflammation

    ITK Deficiency Attenuates Alveolar Hemorrhage by Enhancing Regulatory T Cell-Mediated Tissue Resilience

    Mohammad Saddam Hossain, Ali Mobeen ... Mobin Karimi
34. 1. Developmental Biology

    Junctional β-Catenin Stabilization Links Wnt Signaling and Force Generation

    Agimaa Otgonbaatar, Sujithra Shankar ... Nicholas S Tolwinski
35. 1. Neuroscience

    Identifying molecular instructions to hard-wire a sensory neuron’s synaptic connectivity

    Júnia Vieira dos Santos, Renee Yin Yu ... Brian E Chen
36. 1. Cell Biology

    CROP2, a Retriever–PROPPIN complex mediating protein export from endosomes to the plasma membrane in human cells

    Maria Giovanna De Leo, Andreas Mayer

    Endosomes operate several exit routes that sort protein cargo and depend on pathway-specific associations of a PROPPIN with the responsible protein coat, such as the here identified CROP2, to support the departure of the cargo carriers.
37. 1. Developmental Biology
    2. Genetics and Genomics

    Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

    Zenith D Rudich, Jiaxi Guan ... Jeremy M Van Raamsdonk
38. 1. Neuroscience

    Excitation–inhibition balance controls coupling stability and network reorganization in a plastic Kuramoto model

    Satoshi Kuroki, Kenji Mizuseki
39. 1. Computational and Systems Biology

    Large-scale synthetic data enable digital twins of human excitable cells

    Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy

    Large-scale synthetic datasets enable construction of digital twins of individual human excitable cells from a single voltage-clamp recording.
40. 1. Structural Biology and Molecular Biophysics

    Structural dynamics of IRE1 and its interaction with unfolded peptides

    Elena Spinetti, Grzegorz Ścibisz ... Roberto Covino

    A unified structural model of IRE1 activation reconciles conflicting sensing theories by characterizing specific peptide-binding sites and the mechanism by which BiP regulates oligomerization during the unfolded protein response.
41. 1. Evolutionary Biology

    The population structure of invasive Lantana camara is shaped by its mating system

    P Praveen, Rajesh Gopal, Uma Ramakrishnan

    Invasive Lantana camara exhibits strong genetic structure, unlike many invasive species, likely driven by predominant self-fertilization across its invasive range rather than the presence of multiple species.
42. 1. Computational and Systems Biology

    Functional muscle networks as biomarkers of post-stroke motor impairment and therapeutic responsiveness

    David O'Reilly, Giorgia Pregnolato ... Giacomo Severini

    The proposed muscle network analysis framework identifies a redundancy-to-synergy shift as a marker of stroke recovery, yielding new biomarkers that could objectively quantify functional impairment and rehabilitation efficacy.
43. 1. Plant Biology
    2. Ecology

    Asymmetric introgression and thermal advantage jointly drive climate-mediated lineage turnover in a mixed-ploidy reed

    Lele Liu, Wenyi Sheng ... Weihua Guo
44. 1. Neuroscience

    Zapit: Open Source Laser-Scanning Photostimulation For Neuroscience

    Michael Lohse, Oliver M Gauld ... Robert AA Campbell
45. 1. Biochemistry and Chemical Biology

    Identification of key Y₄R residues enables the discovery of selective non-peptide small-molecule agonists

    Tim Pelczyk, Corinna Schüß ... Annette G Beck-Sickinger
46. 1. Cell Biology
    2. Physiology

    Aging induced structural alterations in SR-Mitochondria interaction in skeletal muscle: Emerging insights

    Unmod Senapati, Barsha Priyadarshini Kar ... Naresh Chandra Bal
47. 1. Cell Biology
    2. Microbiology and Infectious Disease

    Enteropathogenic Escherichia coli-mediated fast and coordinated Ca^²+ responses regulate NF-κB activation

    Fangrui Guo, Roberto Ornelas Guevara ... Guy Tran Van Nhieu

    Through low levels of extracellular ATP, EPEC induces small, rapid and coordinated Ca²⁺ responses in epithelial cells, a yet unreported pattern, that down-regulate inflammation at the onset of infection.
48. 1. Neuroscience

    Two time scales of adaptation in human learning rates

    Jonas Simoens, Senne Braem ... Tom Verguts

    Humans adapt learning rates on both a fast and a slow time scale, and the central orbitofrontal cortex may represent the slow time scale.
49. 1. Neuroscience

    PKMζ-PKCι/λ double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor

    Double-knockout of PKMζ and the other atypical PKC, PKCι/λ, reveals that, without PKMζ for maintenance, PKCι/λ becomes persistently active to sustain hippocampal late-LTP and long-term memory.
50. 1. Developmental Biology

    Comparative single-cell transcriptomic roadmap of mammalian fetal ovarian development

    Yifei Fang, Shiyao Han ... Jingyue Ellie Duan
51. 1. Cell Biology

    Opto-MDMi: a dual-lock optogenetic system for robust activation of endogenous p53

    Tatsuki Tsuruoka, Takashi Sumikama ... Kazuhiro Aoki
52. 1. Cell Biology
    2. Microbiology and Infectious Disease

    A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

    Surbhi Verma, Shweta Thakur ... Dhiraj Kumar
53. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Distinct prokaryotic gut microbiome and proviral-immune axes of pathophysiology in Sickle Cell Disease

    Zachary N Flamholz, Jennifer De Los Santos ... Libusha Kelly
54. 1. Neuroscience

    The openretina Project: Collaborative Retina Modelling Across Datasets and Species

    Federico D’Agostino, Thomas Zenkel ... Matthias Bethge
55. 1. Developmental Biology

    Single-cell characterization of anterior segment development in the mouse reveals the cell types, pathways, and signals driving formation of the trabecular meshwork and Schlemm’s canal

    Revathi Balasubramanian, Nicholas Tolman ... Simon WM John

    High-resolution single-cell transcriptomics reveals the molecular programs and signaling networks driving Schlemm's canal and trabecular meshwork development, establishing a foundation for understanding glaucoma pathogenesis.
56. 1. Computational and Systems Biology
    2. Developmental Biology

    Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation

    Morena Raiola, Miquel Sendra Sendra ... Miguel Torres

    A computational pipeline leverages mammalian heart development videos to extract tissue deformation patterns and generate a virtual fate map tool that provides new insights into cardiac morphogenesis.
57. 1. Microbiology and Infectious Disease

    Reactive oxygen detoxification contributes to Mycobacterium abscessus antibiotic survival

    Nicholas A Bates, Ronald Rodriguez ... Bennett H Penn

    Antibiotics that inhibit translation cause a burst in reactive oxygen species, and these must be detoxified by factors such as KatG for cells to survive.
58. 1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The adaptive landscapes of three global Escherichia coli transcriptional regulators

    Cauã Antunes Westmann, Leander Goldbach, Andreas Wagner

    Across three global Escherichia coli regulators, identical starting sequences can evolve toward many distinct strong-binding peaks, with chance, historical contingency, and evolutionary bias shaping which outcomes prevail.
59. 1. Developmental Biology

    A genetic screen reveals dosage-sensitive effects of ASD genes and identifies domino as a regulator of synaptic and behavioral phenotypes

    Ellen Stirtz, Zachary B Madaj ... Adelheid Lempradl
60. 1. Structural Biology and Molecular Biophysics

    Structural basis for site-specific histone H3 acetylation-dependent regulation of RNAPII transcription through nucleosomes

    Takumi Oishi, Suguru Hatazawa ... Hitoshi Kurumizaka
61. 1. Structural Biology and Molecular Biophysics

    A stable cryogenic fluorescence microscope for correlative super-resolution light and electron microscopy

    Soheil Mojiri, Joseph M Dobbs ... Jonas Ries
62. 1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Germline-somatic residue synergy reshapes antibody encounter-state pathways to enhance HIV-1 recognition

    Sangita Kachhap, Yishak Bililign ... Rory Henderson
63. 1. Neuroscience

    Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex

    Brandon Williams, Riya Dahal ... John A White
64. 1. Developmental Biology
    2. Genetics and Genomics

    Flexible and high-throughput simultaneous profiling of gene expression and chromatin accessibility in single cells

    Volker Soltys, Moritz A Peters ... Yingguang Frank Chan

    A single-cell multiomic technique measuring both transcription and chromatin accessibility in the same cell.
65. 1. Neuroscience

    Organization of circuits linking descending input to motor output in the Drosophila Male Adult Nerve Cord connectome

    Han SJ Cheong, Katharina Eichler ... Gwyneth M Card

    Circuit analyses of synaptic connectivity in networks connecting descending and motor neurons in the Drosophila Male Adult Nerve Cord connectome reveal the modular network organization of descending to motor pathways.
66. 1. Neuroscience

    Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

    Kexin Qi, Yuming Chai ... Quan Wen

    Serotonin promotes a sleep-independent quiescent state through selective modulation of motor neural population dynamics.
67. 1. Neuroscience

    Neural categorization of visual words of alphabetic and non-alphabetic languages

    Guo Zheng, Shihui Han

    Explaining the neural mechanisms underlying language-based, spontaneous categorization of visual words of alphabetic and non-alphabetic languages by combining electroencephalography, magnetoencephalography, and a repetition suppression paradigm.
68. 1. Neuroscience

    Serial dependence predicts generalization in perceptual learning

    Noga Pinchuk-Yacobi, Dov Sagi, Yoram S Bonneh

    A single temporal integration process links momentary perceptual biases to the generalization of learned skills, providing a unifying account of specificity versus flexibility in human learning.
69. 1. Developmental Biology

    Paternal over- and under-nutrition programme fetal and placental development in a sex-specific manner in mice

    Hannah L Morgan, Nader Eid ... Adam J Watkins

    Poor paternal nutrition at the time of conception shapes post-fertilisation developmental trajectory, fetal growth, and placental dynamics.
70. 1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    RNA selectively modulates activity of virulent amyloid PSMα3 and host-defense LL-37 via phase separation and aggregation dynamics

    Bader Rayan, Eilon Barnea ... Meytal Landau

    RNA differentially regulates the assembly pathways of bacterial and host α-helical peptides, revealing supramolecular architecture as a tunable determinant of cytotoxic and antimicrobial function.
71. 1. Structural Biology and Molecular Biophysics

    Enhanced processivity and collective force production of kinesin-1 at low radial forces

    Andrew M Hensley, Ahmet Yildiz

    Reducing vertical forces reveals kinesin-1 as a robust motor capable of sustaining high loads and efficiently generating large collective forces with multiple motors.
72. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2, and -3

    Crystal R Noell, Tzu-Chen Ma ... William O Hancock

    All three kinesin transport families exhibit unexpectedly slow dissociation under load, explaining robust competition with dynein during bidirectional cargo transport.
73. 1. Neuroscience

    The view tolerance of human identity recognition depends on horizontal face information

    Alexia Roux-Sibilon, Helene Dumont ... Valerie Goffaux

    View-tolerant identity recognition in humans depends on the stable identity cues provided by horizontal facial information.
74. 1. Cell Biology
    2. Neuroscience

    FMRP regulates neuronal RNA granules containing stalled ribosomes, not where ribosomes stall

    Jewel T-Y Li, Mehdi Amiri ... Wayne S Sossin

    The loss of FMRP does not affect how neuronal ribosomes are stalled or where they are stalled, but reduces the number of neuronal RNA granules that contain stalled ribosomes.
75. 1. Cancer Biology
    2. Cell Biology

    DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

    Simar Pal Singh, Kumar Mangalam ... Annemiek B van Spriel

    DuoHexaBody‑CD37 triggers complement‑independent cytotoxic signaling in diffuse large B-cell lymphoma (DLBCL), revealing therapeutic pathways that can be exploited to enhance tumor cell killing through targeted combination strategies.
76. 1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Cluster size determines internal structure of transcription factories in human cells

    Massimiliano Semeraro, Giuseppe Negro ... Davide Marenduzzo

    In a polymer model of chromatin that explicitly incorporates different types of transcription factors, both specialised and mixed factories emerge naturally, with their composition governed by their size.
77. 1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Stabilizing by steering: Enhancing bacterial motility by non-uniform diffusiophoresis

    Viet Sang Doan, Ali Nikkhah, Sangwoo Shin
78. 1. Physics of Living Systems

    Mechanical interaction enables a collective mode of protocell proliferation

    Yisen Li, Yilin Wu
79. 1. Neuroscience

    Visuomotor flexibility is embedded in the topography of frontal cortex

    Nicholas M Dotson, John H Reynolds
80. 1. Neuroscience

    A paradoxical relationship between mitochondrial calcium regulation and retinal ganglion cell degeneration after axon damage

    Sean McCracken, Minglei Zhao ... Philip R Williams
81. 1. Microbiology and Infectious Disease
    2. Computational and Systems Biology

    Petabase-scale Papillomavirus Discovery

    Jessica YQ Shen, Anton Korobeynikov ... Artem Babaian
82. 1. Neuroscience

    Connections across regional glymphatic clearance, neural activity and amyloid-β deposition in cortex

    Yifei Li, Xiao Zhu ... Min Lou
83. 1. Physics of Living Systems

    Design of a minimal, allosteric, and ATPase-like machine using mechanical linkages

    Tosan Omabegho
84. 1. Cell Biology

    CHOP promotes the transition to chronic integrated stress response signaling with suppression of hepatocyte identity

    Theo F Velarde, Kaihua Liu ... D Thomas Rutkowski
85. 1. Genetics and Genomics
    2. Immunology and Inflammation

    Host Endoplasmic Reticulum Stress and Interferon Responses Contribute to AAV-Induced Ocular Toxicity

    Apolonia Gardner, Christin Hong ... Constance L Cepko
86. 1. Cell Biology

    Human mitochondrial DNA variants influence telomere length: evidence from a transmitochondrial cybrid model

    Manon Mahieu, Jean-Philippe Defour ... Anabelle Decottignies
87. 1. Neuroscience

    Arm Control and its Recovery after Selective Lesions of Sensorimotor Cortex and the Red Nucleus: A Kinematic Study in Non-Human Primates

    Anna Baines, Annie Poll ... Stuart N Baker
88. 1. Cell Biology
    2. Neuroscience

    All-optical analysis of electrical coupling in muscle ensembles reveals contributions of individual innexins to cell synchronization and locomotion

    Nora Elvers, Amelie Bergs ... Alexander Gottschalk
89. 1. Neuroscience

    The effect of physical activity on brain structure and cognitive function in the population-based cohort of LIFE-Adult Study

    Polona Kalc, Robert Dahnke ... Christian Gaser

    Although physical exercise could be a beneficial protective factor for brain health in later life, older adults tend to overestimate their actual levels of activity.
90. 1. Microbiology and Infectious Disease

    A network perspective on the role of c-di-GMP-associated protein complexes in biofilm formation

    Marie-Francoise Noirot-Gros, Peter Larsen ... Philippe Noirot
91. 1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Comparative multi-omics of the macrophage response to infection with Mycobacterium tuberculosis complex bacteria reveals pathogen-driven epigenomic reprogramming

    Thomas J Hall, Morgane Mitermite ... David E MacHugh
92. 1. Neuroscience

    Verbal versus Nonverbal Processing Leads to Generalized Hemispheric Laterality Effects that Span Multiple Networks

    Wendy Sun, Lauren M DiNicola, Randy L Buckner
93. 1. Cell Biology

    PXGS: a Poly-Transgene Expression System based on Mutually Exclusive Splicing of Dscam

    Renee Yin Yu, Alyeri Bucio-Méndez, Brian E Chen
94. 1. Neuroscience

    Sex differences in exploration–exploitation strategies during home-cage decision making

    Chantelle L Murrell, Alex A Legaria ... Alexxai V Kravitz
95. 1. Neuroscience

    The Crunchometer, a low-cost, open-source acoustic analysis of feeding microstructure

    Elvi Gil Lievana, Benjamin Arroyo ... Ranier Gutierrez

    Making the moment-to-moment dynamics of solid-food intake measurable in any laboratory enables researchers to map the brain circuits that control appetite and accelerate the development of treatments for obesity.
96. 1. Chromosomes and Gene Expression

    Linking germline telomere removal to global programmed DNA elimination in Tetrahymena genome differentiation

    Kohei Nagao, Alix Lemoine ... Kazufumi Mochizuki

    Tetrahymena germline chromosome ends contain germline-limited sequences that are removed by chromosome breakage, a critical step for programmed DNA elimination of other germline-limited sequences and successful sexual reproduction.
97. 1. Epidemiology and Global Health

    A natural experiment in Kenya reveals durable immunosuppressive effects of early childhood malaria: a longitudinal cohort study

    Mercy S Safari, Timothy O Makori ... Charles J Sande

    Early-life malaria exposure leaves a durable immunological imprint associated with reduced antibody responses to unrelated infections and vaccines.
98. 1. Structural Biology and Molecular Biophysics

    In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

    Yanqing Yang, Lulu Qiao ... Ruhong Zhou

    Computer-Aided Aptamer Modeling and Optimization (CAAMO) enables structure-guided RNA aptamer affinity maturation, producing a SARS-CoV-2 RBD (receptor binding domain) binder that rivals neutralizing antibodies and retains predicted activity across variants.
99. 1. Biochemistry and Chemical Biology

    A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC1 Oligomerization Inhibitor

    Varun Ravishankar, Luís Borges-Araújo ... Lucie Bergdoll
100. 1. Genetics and Genomics

     Fourfold lifespan extension in C. elegans daf-2 mutant males

     Mike Russell, Michelle Lin ... Liou Y Sun
101. 1. Neuroscience

     Relating layer fMRI signals to acoustics and intracranial neuronal activity in the human auditory cortex in a naturalistic design

     Hsin-Ju Lee, Jyrki Ahveninen ... Fa-Hsuan Lin
102. 1. Computational and Systems Biology

     Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer’s Disease

     Tomoharu Katayama, Hikaru Sugimoto ... Shinya Kuroda
103. 1. Neuroscience

     Diverse paths for chemoreception in ciliated neurons contacting the cerebrospinal fluid in the spinal cord

     Emily Verran, Louise Moizan ... Claire Wyart
104. 1. Cell Biology

     Cytoplasmic circular dsDNA is a key constituent of stress granules

     Natalia A Demeshkina, Adrian R Ferré-D'Amaré

     Extrachromosomal circular DNA has been identified as a novel component of stress granule cores, indicating its essential involvement in eukaryotic stress response pathways at the level of protein synthesis.
105. 1. Biochemistry and Chemical Biology
     2. Computational and Systems Biology

     Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro

     Ryota Miyachi, Norikazu Ichihashi

     The in vitro experiments that used the artificial genetic codes tested here did not provide support for the error minimization theory.
106. 1. Neuroscience

     Human cerebellum and ventral tegmental area interact during extinction of learned fear

     Enzo Nio, Patrick Pais Pereira ... Dagmar Timmann

     The cerebellum and ventral tegmental area interact during unexpected omissions of aversive outcomes in humans, supporting a role for reward-like prediction error signaling in fear extinction learning.
107. 1. Evolutionary Biology
     2. Immunology and Inflammation

     Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage

     Joshua L Cherry

     The unusually high genetic diversity of MHC genes cannot be explained by heterozygote advantage alone because heterozygote advantage is not expected without some other driver of diversity.
108. 1. Cancer Biology

     PCNA-Polκ-Polδ/USP18 axes stabilize replication fork and restart to reduce cisplatin cytotoxicity

     Ipsita Subhadarsini, Jugal Kishor Sahu ... Narottam Acharya
109. 1. Microbiology and Infectious Disease
     2. Physics of Living Systems

     Cooperative antibiotic response in coupled biofilm and planktonic E. faecalis communities

     Gabriela Fernandes Martins, Keanu Alexander Guardiola-Flores ... Kevin Wood
110. 1. Neuroscience

     Astrocytic Nonsense-mediated mRNA decay regulates calcium signaling to support synapse function and restrain anxiety

     Pablo J Lituma, Aykut Deveci ... Dilek Colak
111. 1. Neuroscience

     Primate Hippocampus Reveals Distinct Rules for Associative Synaptic Plasticity

     Anoop Manakkadan, Krishna Kumar ... Sreedharan Sajikumar
112. 1. Neuroscience

     Congenital aphantasia reveals frontotemporal and cingulate structural alterations underlying conscious access to imagery

     Yusaku Takamura, Romain Delsanti ... Jianghao Liu
113. 1. Neuroscience

     Nanoscale organization of betaII-spectrin within segments of the membrane-associated periodic skeleton in mouse sciatic nerve axons

     Nahir Guadalupe Gazal, Gonzalo Escalante ... Nicolás Unsain
114. 1. Biochemistry and Chemical Biology
     2. Neuroscience

     Estimating the replicability of Brazilian biomedical science

     The Brazilian Reproducibility Initiative
115. 1. Neuroscience

     Anterior cingulate cortex monitors action state and action content in complex associative learning

     Wenqiang Huang, Arron F Hall ... Dong V Wang

     ACC contains specialized neurons that sustain rich action-relevant information after action execution, enabling prolonged action monitoring, and supporting complex associative linking across events.
116. 1. Structural Biology and Molecular Biophysics

     Yoda molecules agonize PIEZO2

     Tharaka D Wijerathne, Aneesh Chandrasekharan ... Jérôme J Lacroix
117. 1. Structural Biology and Molecular Biophysics

     Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey

     Go Kasuya, Kaei Ryu ... Koichi Nakajo
118. 1. Neuroscience

     Theta beta ratio in attention deficit hyperactivity disorder using a multiverse analysis

     Dawid Strzelczyk, Andrea Vetsch, Nicolas Langer

     Individual alpha peak frequency and aperiodic neural activity shape theta-beta ratio estimates, limiting their value as an ADHD biomarker.
119. 1. Microbiology and Infectious Disease

     The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

     Sheng-Li Ming, Meng-Hua Du ... Bei-Bei Chu

     Alphaherpesviruses hijack host epigenetic regulation by promoting HDAC1/2 nuclear export and degradation to activate the DNA damage response, revealing new antiviral therapeutic targets.
120. 1. Computational and Systems Biology
     2. Neuroscience

     Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

     Xiang Zheng, Qiyao Yang ... B Ian Hutchins

     Funding mechanisms impact the cost effectiveness of the science conducted, as extramural NIH grants to universities excel at producing papers and citations, while intramural NIH hiring more effectively translates to clinical impact.
121. 1. Neuroscience

     How attention simplifies mental representations for planning

     Jason da Silva Castanheira, Christina Chang He ... Stephen M Fleming

     Spatial attention controls the information people become aware of and, in turn, incorporate into simplified perceptual representations for use in multi-step planning.
122. 1. Neuroscience

     Kinematic signatures in reaching movements during spaceflight provide evidence that humans underestimate body mass in microgravity

     Zhaoran Zhang, Yu Tian ... Kunlin Wei

     Model-based kinematic analyses link the movement slowing in spaceflight to body mass underestimation.
123. 1. Developmental Biology
     2. Neuroscience

     The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development, and Eml3 null mice are a model of cobblestone brain malformation

     Isabelle Carrier, Eduardo Diez ... Roderick McInnes

     Absence of EML3 in mice leads to delayed embryonic development, small size, perinatal lethality, and the over-migration of neuroblasts due to a defective pial basement membrane.
124. 1. Epidemiology and Global Health
     2. Microbiology and Infectious Disease

     Inferring variant-specific effective reproduction numbers from combined case and sequencing data

     Marlin D Figgins, Trevor Bedford

     Integrating case counts with genomic sequences quantifies real-time transmission advantages of viral variants.
125. 1. Neuroscience

     Whisker-based pre-neuronal and peripheral encoding of surface stickiness

     Isis S Wyche, Michaela A O’Neil, Daniel H O’Connor
126. 1. Neuroscience

     Electroconvulsive stimulation drives cortical spreading depression dependent immediate early gene expression in mice

     Hugo J Ladret, Leonardo Lupori ... Georg B Keller
127. 1. Cell Biology
     2. Microbiology and Infectious Disease

     Cell cycle dependent variation in endocytosis drives phenotypic diversity in M. tuberculosis

     Neeraja Subhash, Sandhya Krishnan Radhakrishnan ... Varadharajan Sundaramurthy
128. 1. Neuroscience

     Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulation

     Alejandro G Rey Hipolito, Michael P Dew ... Roy V Sillitoe
129. 1. Genetics and Genomics
     2. Medicine

     Single-cell transcriptome-wide Mendelian randomization and colocalization analyses reveal immune-cell-specific mechanisms and actionable drug targets in prostate cancer

     Yanggang Hong, Yi Wang ... Jiajun Li
130. 1. Medicine
     2. Neuroscience

     Synthetic torpor in the rat protects the heart from ischaemia-reperfusion injury

     Megan Elley, Ludovico Taddei ... Michael Ambler
131. 1. Computational and Systems Biology
     2. Immunology and Inflammation

     Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions

     Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin

     Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.
132. 1. Neuroscience

     Medial prefrontal cortex encodes but is not required to generate goal-directed actions under threat

     Muhammad S Sajid, Ji Zhou, Manuel A Castro-Alamancos

     Medial prefrontal cortex activity is not required for learning or execution of adaptive avoidance behavior, despite encoding select task features.
133. 1. Cell Biology

     Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

     Qian Lyu, Qingchao Li ... Huijie Zhao

     Deficiency in any of the interdependent C2a proteins (CCDC108, MYCBPAP, and CFAP70) collapses this central pair microtubule-associated projection, disrupting vertebrate ciliary movement, and causing primary ciliary dyskinesia phenotypes in mice.
134. 1. Immunology and Inflammation
     2. Neuroscience

     Cribriform plate microenvironment assembles a suppressive myeloid network during EAE-induced neuroinflammation

     Collin Laaker, Martin Hsu ... Zsuzsanna Fabry

     Regulatory immune cells accumulate at the nose-to-brain interface during neuroinflammation, potentially dampening damaging immune responses.
135. 1. Genetics and Genomics

     Autosomal allelic inactivation at loci with variable replication timing and dosage sensitivity

     Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer

     Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.
136. 1. Immunology and Inflammation

     TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

     Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama

     Uterine natural killer (NK) cells require TGF-β to be derived from conventional NK cells and contribute to successful pregnancy.
137. 1. Structural Biology and Molecular Biophysics

     Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

     Arpa Hudait, Ryan C Burdick ... Gregory A Voth

     Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
138. 1. Cell Biology
     2. Microbiology and Infectious Disease

     Canonical and phosphoribosyl ubiquitination coordinate to stabilize a proteinaceous structure surrounding the Legionella-containing vacuole

     Adriana Steinbach, Chetan Mokkapati ... Shaeri Mukherjee

     Two families of ubiquitin ligases secreted by the intracellular pathogen Legionella pneumophila utilize distinct chemistries to form a stable, ubiquitin-rich structure around the vacuole, which is subsequently disassembled as infection progresses.
139. 1. Neuroscience

     Visual working memory guides attention rhythmically in humans

     Jiachen Lu, Yaochun Cai, Xilin Zhang

     Working memory alternates between remembered items in a rhythmic theta cycle.
140. 1. Biochemistry and Chemical Biology

     Dynamic assembly of malate dehydrogenase–citrate synthase multienzyme complex in the mitochondria

     Joy Omini, Inga Krassovskaya ... Toshihiro Obata

     The yeast mitochondrial malate dehydrogenase–citrate synthase metabolon is a dynamic multienzyme complex that continuously assembles and disassembles in response to respiratory activity, mitochondrial matrix pH, and substrate abundances.
141. 1. Immunology and Inflammation

     Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

     Peter Georgiev, Sheila Johnson ... Arlene H Sharpe

     A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.
142. 1. Neuroscience

     Disentangling cephalopod chromatophores motor units with computer vision

     Mathieu DM Renard, Johann Ukrow ... Gilles Laurent

     The spatial organization of chromatophore-muscle innervation by motoneurons enables the generation of chromatophore-shaped noise, virtual or composite chromatophores, and shape elements such as lines or small blobs.
143. 1. Computational and Systems Biology

     Environmental statistics and sensory experience shape patch foraging strategies in Drosophila larvae

     Akhila Mudunuri, Klára Tučková ... Katrin Vogt
144. 1. Neuroscience

     Efficient Working Memory Maintenance via High-Dimensional Rotational Dynamics

     Laura Ritter, Angus Chadwick
145. 1. Neuroscience

     Dissociating neuronal signatures of spatial attention and behavioural state in the primary vibrissal cortex of mice

     Guthrie P Dyce, Taylor SEG Singh ... Ehsan Arabzadeh
146. 1. Microbiology and Infectious Disease
     2. Ecology

     Central carbon metabolism switching in lytic versus temperate coral reef viral communities

     Jacob Kelman, Meena Khan ... Ben Knowles
147. 1. Evolutionary Biology
     2. Genetics and Genomics

     Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas

     Jacob D Bowman, Neide Silva ... Vincent J Lynch

     Genes associated with male reproductive biology appear to be under relaxed selective constraint in a primate species with low sperm competition.
148. 1. Chromosomes and Gene Expression

     Impacts of DNA methylation on H2A.Z deposition and nucleosome stability

     Rochelle M Shih, Yasuhiro Arimura ... Hironori Funabiki

     DNA methylation suppresses H2A.Z deposition by inhibiting recruitment of the chaperone SRCAP, while the structural study suggests that methylated DNA can make the H2A.Z nucleosome slightly more accessible.
149. 1. Neuroscience

     Continuous developmental changes in word recognition and language learning across early childhood

     Michael C Frank, Virginia A Marchman ... Martin Zettersten

     Analysis of data across many different studies shows that children's word recognition improves continuously from infancy through age 5 years, and shows strong coupling with early vocabulary.
150. 1. Biochemistry and Chemical Biology

     Profiling of terminating ribosomes reveals translational control at stop codons

     Longfei Jia, Yuanhui Mao ... Shu-Bing Qian

     Systematic characterization of terminating ribosomes uncovers sequence features influencing ribosome dynamics at stop codons with direct implications in 3' UTR translation.
151. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     Arrayed single-gene perturbations identify drivers of human anterior neural tube closure

     Roya E Huang, Giridhar M Anand ... Sharad Ramanathan

     A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure.
152. 1. Neuroscience

     Multiple event segmentation mechanisms in the human brain

     Tan T Nguyen, Joset A Etzel ... Jeffrey M Zacks

     The brain uses separate prediction error and prediction uncertainty signals to trigger event boundaries.
153. 1. Genetics and Genomics

     Optimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish

     Yosuke Ono, Martin Peterka ... Steffen Scholpp

     Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.
154. 1. Neuroscience

     Development of auditory and spontaneous movement responses to music over the first postnatal year

     Trinh Nguyen, Félix Bigand ... Giacomo Novembre

     Although auditory encoding of music is robust early in infancy, the transformation of this input into movement patterns develops substantially over the first postnatal year, without reaching full maturity.
155. 1. Chromosomes and Gene Expression

     Ligand-dependent enhancer activation indirectly modulates non-target promoters in a chromatin domain

     Darshika Bohra, Zubairul Islam ... Dimple Notani

     Ligand-driven enhancer activation selectively boosts target gene expression while indirectly repressing neighboring non-target genes, revealing dynamic and competitive regulation during early transcriptional responses.
156. 1. Ecology

     Coordinated beak–tongue mechanics enable dexterous seed manipulation in songbirds

     Maja Mielke, Falk Mielke ... Sam Van Wassenbergh
157. 1. Neuroscience

     Noise in Competing Representations Determines the Direction of Memory Biases

     Andrey Chetverikov, Sabrina Hansmann-Roth
158. 1. Neuroscience

     Rehabilitation drives functional reorganization of intact corticospinal-supraspinal projections following partial spinal cord injury

     James Bonanno, Sheel Trivedi ... William BJ Cafferty
159. 1. Computational and Systems Biology
     2. Neuroscience

     SqueakPose Studio, an end-to-end platform for pose estimation and real-time edge-AI deployment

     David L Haggerty, Caleb Browning Darden, David Lovinger

     Integrated pose estimation, video acquisition, and edge deployment tools make real-time behavioral analysis more accessible to neuroscience laboratories.
160. 1. Computational and Systems Biology
     2. Physics of Living Systems

     A coma pattern-based autofocusing method resolves bacterial cold shock response at single-cell level

     Sihong Li, Zhixin Ma ... Shuqiang Huang

     A robust autofocusing method enables continuous single-cell imaging during rapid cooling, revealing sustained bacterial proliferation hidden by growth arrest inferred from optical-density measurements.
161. 1. Cell Biology
     2. Genetics and Genomics

     Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival

     Serhiy Havrylov, Armin M Gamper, Ordan J Lehmann

     Genetic experiments integrated with ChIP-sequencing and CRISPR interference reveal that overexpression of Foxc1 transcriptionally activates the expression of Arhgap36 and dysregulates multiple facets of Hedgehog pathway activity.
162. 1. Cell Biology
     2. Computational and Systems Biology

     Lipid packing contributes to the confinement of caveolae to the plasma membrane

     Elin Larsson, Aleksei Kabedev ... Richard Lundmark

     Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.
163. 1. Cell Biology
     2. Neuroscience

     Activity-dependent CO₂ production in the axon triggers opening of Connexin32 in the Schwann cell paranode

     Jack Butler, Lowell Mott ... Nicholas Dale

     Gaseous CO₂ acts as a neuron to glia messenger in peripheral myelin to trigger opening of Schwann Cell Cx32 hemichannels in response to axonal action potential propagation.
164. 1. Microbiology and Infectious Disease

     A protease-sensing circuit links neutrophil inflammation to virulence regulation in Streptococcus pyogenes

     Stephanie Guerra, Ananya Dash ... Christopher N LaRock
165. 1. Neuroscience

     NPAS4 refines spatial and temporal firing in CA1 pyramidal neurons

     Anja Payne, Daniel A Heinz ... Brenda L Bloodgood
166. 1. Neuroscience

     Early Visual Cortex Supports One-Shot Episodic Memory via Spatially Tuned Reactivation

     Robert Woodry, Jonathan Winawer, Serra E Favila
167. 1. Neuroscience

     If Grid Cells are the Answer, What is the Question? A Review of Normative Grid Cell Theory

     William Dorrell, James Whittington
168. 1. Computational and Systems Biology

     TopoMetry systematically learns and evaluates the latent geometry of single-cell data

     David Sidarta-Oliveira, Ana I Domingos, Licio A Velloso

     A framework for analyzing single-cell genomics data, in which geometrical properties are harnessed to obtain insights on cellular diversity, including precise clustering, clear visualizations, and intuitive diagnostics.
169. 1. Biochemistry and Chemical Biology
     2. Cell Biology

     Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy

     Hao Chen, Haocheng Wang ... Jiou Wang

     Minimally disruptive genetic code expansion enables faithful, site-specific labeling of G3BP1 and TDP-43, revealing native stress granule dynamics and ALS-linked protein behavior in live cells.
170. 1. Medicine

     Navigating the path: Advice to physician-scientists on choosing a clinical specialty

     Talia Swartz, Jose E Cavazos ... Christopher S Williams

     This article provides critical insights in guiding aspiring physician-scientist medical students on how to choose a clinical specialty.
171. 1. Neuroscience

     Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex

     Sohrab Salimian, Harrison Grier, Matthew Tyler Kaufman

     Single neurons in mouse sensorimotor cortex are organized by their activity features into distinct subpopulations with area-spanning footprints whose boundaries align closely with anatomical and somatotopic borders.
172. 1. Neuroscience

     Analysis of dendritic input currents during place field dynamics

     Bence Fogel, Balazs B Ujfalussy

     A new analysis method to measure the propagation of different membrane currents along complex dendritic trees reveals the conditions leading to burst firing in a computational model of place cells.
173. 1. Neuroscience

     A battery of image classification challenges reveals shared and distinct object categorization behavior across monkeys, humans, and deep networks

     Han Zhang, Zhihao Zheng ... Gouki Okazawa
174. 1. Structural Biology and Molecular Biophysics

     A membrane insertion code for intrinsically disordered proteins

     Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou
175. 1. Immunology and Inflammation

     Application of Engineered NK-92 Cell Extracellular Vesicles in the Treatment of Systemic Lupus Erythematosus

     Yu Sun, Zeyu Tang ... Xiaowei Dou
176. 1. Developmental Biology

     Genome-wide discovery of cis-regulatory elements in a large genome

     Gillian Forbes, Emilia Skafida ... Mathilde Paris
177. 1. Cell Biology

     Membrane contact site resident PTP1B limits superoxide production by suppressing a Syk-Shc1-Phagocyte Oxidase relay

     Minhyoung Lee, Haggag S Zein ... Gregory D Fairn
178. 1. Genetics and Genomics
     2. Evolutionary Biology

     Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci

     Michele Marconcini, Steeve Cruchet ... Richard Benton
179. 1. Cell Biology
     2. Developmental Biology

     Wunen(s) help navigate Primordial Germ Cells by attenuating Hedgehog signaling

     Amrita Roy, Adheena Elsa Roy ... Girish Deshpande
180. 1. Developmental Biology

     Ectopic hAMH-driven SOX17 expression induces hyperplastic Sertoli valve formation in mouse testes

     Xiao Han, Aya Uchida ... Yoshiakira Kanai
181. 1. Evolutionary Biology

     RegEvol: detection of directional selection in regulatory sequences through phenotypic predictions and phenotype-to-fitness functions

     Alexandre Laverré, Thibault Latrille, Marc Robinson-Rechavi
182. 1. Evolutionary Biology

     Developmental bias explains the evolutionary trend towards simple leaf shapes

     James S Malone, Nora S Martin ... Ard A Louis
183. 1. Cell Biology
     2. Immunology and Inflammation

     Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses during inflammation

     Priyanka Gajwani, Li Wang ... Jalees Rehman

     Inflammatory activation of endothelial cells triggers Pink1-dependent mitophagy and mitochondrial formyl peptides release, which drives neutrophil recruitment and lung injury.
184. 1. Neuroscience

     Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys

     Kathryn Branam, Joshua I Gold, Long Ding

     The subthalamic nucleus contains subpopulations with different contributions to deliberative decision-making based on noisy evidence and reward-driven preferences.